CANX — 54 ClinVar variants
All ClinVar germline CANX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Likely benign · 50 Uncertain significance
Full CANX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CANX p.Ala20Ser Uncertain significance Single submitter
- CANX p.Ala336Thr Uncertain significance Single submitter
- CANX p.Ala421Val Uncertain significance Single submitter
- CANX p.Arg480Leu Uncertain significance Single submitter
- CANX p.Asp142Gly Uncertain significance Single submitter
- CANX p.Asp432Tyr Uncertain significance Single submitter
- CANX p.Glu215Lys Uncertain significance Single submitter
- CANX p.Gly212Cys Uncertain significance Single submitter
- CANX p.Gly511Asp Uncertain significance Single submitter
- CANX p.Gly560Ser Uncertain significance Single submitter
- CANX p.His206Arg Uncertain significance Single submitter
- CANX p.Ile29Met Uncertain significance Single submitter
- CANX p.Ile439Val Uncertain significance Single submitter
- CANX p.Leu140Gln Uncertain significance Single submitter
- CANX p.Leu497Pro Uncertain significance Single submitter
- CANX p.Leu548Arg Uncertain significance Single submitter
- CANX p.Pro481Leu Uncertain significance Single submitter
- CANX p.Ser392Gly Uncertain significance Single submitter
- CANX p.Ser81Ala Uncertain significance Single submitter
- CANX p.Thr211Lys Uncertain significance Single submitter
- CANX p.Tyr393His Uncertain significance Single submitter
- CANX p.Val331Ile Uncertain significance Single submitter
- CANX p.Val368Ile Uncertain significance Single submitter
- CANX p.Val469Ile Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CANX p.Ala460Thr Uncertain significance Single submitter
- CANX p.Arg282Gln Likely benign Single submitter
- CANX p.Arg415Ile Uncertain significance Single submitter
- CANX p.Arg590Gln Uncertain significance Single submitter
- CANX p.Asp25Val Uncertain significance Single submitter
- CANX p.Asp335Gly Uncertain significance Single submitter
- CANX p.Asp34His Uncertain significance Single submitter
- CANX p.Asp94Asn Uncertain significance Single submitter
- CANX p.Glu277Gly Uncertain significance Single submitter
- CANX p.Glu321Lys Uncertain significance Single submitter
- CANX p.Glu475Lys Uncertain significance Single submitter
- CANX p.Glu546Asp Uncertain significance Single submitter
- CANX p.Glu557Ala Uncertain significance Single submitter
- CANX p.Ile355Val Uncertain significance Single submitter
- CANX p.Lys207Arg Uncertain significance Single submitter
- CANX p.Lys311Glu Uncertain significance Single submitter
- CANX p.Lys459Arg Uncertain significance Single submitter
- CANX p.Lys61Asn Uncertain significance Single submitter
- CANX p.Met266Val Uncertain significance Single submitter
- CANX p.Pro269Ser Uncertain significance Single submitter
- CANX p.Pro399Ala Uncertain significance Single submitter
- CANX p.Pro405Gln Uncertain significance Single submitter
- CANX p.Pro522Leu Uncertain significance Single submitter
- CANX p.Ser74Cys Uncertain significance Single submitter
- CANX p.Thr49Ile Uncertain significance Single submitter
- CANX p.Val256Met Uncertain significance Single submitter
- CANX p.Val524Met Uncertain significance Single submitter
All CANX variants
Likely benign 4
- p.Arg282Gln Single submitter ⚠
- p.Asn452Ser Single submitter
- p.Ile17Val Single submitter
- p.Ser392Asn Single submitter
Uncertain significance 50
- p.Ala20Ser Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Ala421Val Single submitter ⚠
- p.Ala460Thr Single submitter ⚠
- p.Arg415Ile Single submitter ⚠
- p.Arg480Leu Single submitter ⚠
- p.Arg590Gln Single submitter ⚠
- p.Asp142Gly Single submitter ⚠
- p.Asp25Val Single submitter ⚠
- p.Asp335Gly Single submitter ⚠
- p.Asp34His Single submitter ⚠
- p.Asp432Tyr Single submitter ⚠
- p.Asp94Asn Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu277Gly Single submitter ⚠
- p.Glu321Lys Single submitter ⚠
- p.Glu475Lys Single submitter ⚠
- p.Glu546Asp Single submitter ⚠
- p.Glu557Ala Single submitter ⚠
- p.Gly212Cys Single submitter ⚠
- p.Gly511Asp Single submitter ⚠
- p.Gly560Ser Single submitter ⚠
- p.His206Arg Single submitter ⚠
- p.Ile29Met Single submitter ⚠
- p.Ile355Val Single submitter ⚠
- p.Ile439Val Single submitter ⚠
- p.Leu140Gln Single submitter ⚠
- p.Leu497Pro Single submitter ⚠
- p.Leu548Arg Single submitter ⚠
- p.Lys207Arg Single submitter ⚠
- p.Lys311Glu Single submitter ⚠
- p.Lys459Arg Single submitter ⚠
- p.Lys61Asn Single submitter ⚠
- p.Met266Val Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro399Ala Single submitter ⚠
- p.Pro405Gln Single submitter ⚠
- p.Pro481Leu Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Ser392Gly Single submitter ⚠
- p.Ser74Cys Single submitter ⚠
- p.Ser81Ala Single submitter ⚠
- p.Thr211Lys Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Tyr393His Single submitter ⚠
- p.Val256Met Single submitter ⚠
- p.Val331Ile Single submitter ⚠
- p.Val368Ile Single submitter ⚠
- p.Val469Ile Single submitter ⚠
- p.Val524Met Single submitter ⚠