CAP1 — 71 ClinVar variants
All ClinVar germline CAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
2 Benign · 1 Likely benign · 68 Uncertain significance
Full CAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAP1 p.Ala145Ser Uncertain significance Single submitter
- CAP1 p.Ala161Ser Uncertain significance Single submitter
- CAP1 p.Ala259Ser Uncertain significance Single submitter
- CAP1 p.Ala270Gly Uncertain significance Single submitter
- CAP1 p.Ala85Val Uncertain significance Single submitter
- CAP1 p.Arg119Trp Uncertain significance Single submitter
- CAP1 p.Arg123Gln Uncertain significance Single submitter
- CAP1 p.Arg29His Uncertain significance Single submitter
- CAP1 p.Arg313Gln Uncertain significance Single submitter
- CAP1 p.Arg313Leu Uncertain significance Single submitter
- CAP1 p.Asp176Gly Uncertain significance Single submitter
- CAP1 p.Glu136Lys Uncertain significance Single submitter
- CAP1 p.Gly124Ser Uncertain significance Single submitter
- CAP1 p.Gly39Glu Uncertain significance Single submitter
- CAP1 p.His281Asp Uncertain significance Single submitter
- CAP1 p.Ile267Val Uncertain significance Single submitter
- CAP1 p.Ile367Val Uncertain significance Single submitter
- CAP1 p.Ile408Thr Uncertain significance Single submitter
- CAP1 p.Leu322Phe Uncertain significance Single submitter
- CAP1 p.Leu378Phe Uncertain significance Single submitter
- CAP1 p.Lys121Asn Uncertain significance Single submitter
- CAP1 p.Met4Ile Uncertain significance Single submitter
- CAP1 p.Pro35Leu Uncertain significance Single submitter
- CAP1 p.Ser25Pro Uncertain significance Single submitter
- CAP1 p.Ser266Arg Uncertain significance Single submitter
- CAP1 p.Thr315Ile Uncertain significance Single submitter
- CAP1 p.Tyr172His Uncertain significance Single submitter
- CAP1 p.Val21Ile Uncertain significance Single submitter
- CAP1 p.Val357Ile Uncertain significance Single submitter
- CAP1 p.Val69Met Uncertain significance Single submitter
- CAP1 p.Val8Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CAP1 p.Ala259Thr Uncertain significance Single submitter
- CAP1 p.Ala302Val Uncertain significance Single submitter
- CAP1 p.Ala52Val Uncertain significance Single submitter
- CAP1 p.Arg254Cys Uncertain significance Single submitter
- CAP1 p.Arg254His Uncertain significance Single submitter
- CAP1 p.Arg29Cys Likely benign Single submitter
- CAP1 p.Gln45His Uncertain significance Single submitter
- CAP1 p.Gln45Pro Uncertain significance Single submitter
- CAP1 p.Gly219Arg Uncertain significance Single submitter
- CAP1 p.Gly227Arg Uncertain significance Single submitter
- CAP1 p.Gly291Asp Uncertain significance Single submitter
- CAP1 p.Gly446Asp Uncertain significance Single submitter
- CAP1 p.Gly446Ser Uncertain significance Single submitter
- CAP1 p.His72Asn Uncertain significance Single submitter
- CAP1 p.Ile353Met Uncertain significance Single submitter
- CAP1 p.Ile370Val Uncertain significance Single submitter
- CAP1 p.Leu104Phe Uncertain significance Single submitter
- CAP1 p.Leu187Phe Uncertain significance Single submitter
- CAP1 p.Leu59Ser Uncertain significance Single submitter
- CAP1 p.Lys170Arg Uncertain significance Single submitter
- CAP1 p.Met162Thr Uncertain significance Single submitter
- CAP1 p.Met278Thr Uncertain significance Single submitter
- CAP1 p.Pro221Leu Uncertain significance Single submitter
- CAP1 p.Pro224Leu Uncertain significance Single submitter
- CAP1 p.Pro241Leu Uncertain significance Single submitter
- CAP1 p.Ser109Leu Uncertain significance Single submitter
- CAP1 p.Ser246Leu Uncertain significance Single submitter
- CAP1 p.Ser310Phe Uncertain significance Single submitter
- CAP1 p.Ser310Tyr Uncertain significance Single submitter
- CAP1 p.Ser36Leu Uncertain significance Single submitter
- CAP1 p.Thr360Ala Uncertain significance Single submitter
- CAP1 p.Val115Leu Uncertain significance Single submitter
- CAP1 p.Val213Met Uncertain significance Single submitter
- CAP1 p.Val293Ala Uncertain significance Single submitter
- CAP1 p.Val337Ile Uncertain significance Single submitter
- CAP1 p.Val341Met Uncertain significance Single submitter
- CAP1 p.Val44Met Uncertain significance Single submitter
- CAP1 p.Val470Met Uncertain significance Single submitter
All CAP1 variants
Likely benign 1
- p.Arg29Cys Single submitter ⚠
Uncertain significance 68
- p.Ala145Ser Single submitter ⚠
- p.Ala161Ser Single submitter ⚠
- p.Ala259Ser Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala270Gly Single submitter ⚠
- p.Ala302Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg313Gln Single submitter ⚠
- p.Arg313Leu Single submitter ⚠
- p.Asp176Gly Single submitter ⚠
- p.Gln45His Single submitter ⚠
- p.Gln45Pro Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly219Arg Single submitter ⚠
- p.Gly227Arg Single submitter ⚠
- p.Gly291Asp Single submitter ⚠
- p.Gly39Glu Single submitter ⚠
- p.Gly446Asp Single submitter ⚠
- p.Gly446Ser Single submitter ⚠
- p.His281Asp Single submitter ⚠
- p.His72Asn Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile353Met Single submitter ⚠
- p.Ile367Val Single submitter ⚠
- p.Ile370Val Single submitter ⚠
- p.Ile408Thr Single submitter ⚠
- p.Leu104Phe Single submitter ⚠
- p.Leu187Phe Single submitter ⚠
- p.Leu322Phe Single submitter ⚠
- p.Leu378Phe Single submitter ⚠
- p.Leu59Ser Single submitter ⚠
- p.Lys121Asn Single submitter ⚠
- p.Lys170Arg Single submitter ⚠
- p.Met162Thr Single submitter ⚠
- p.Met278Thr Single submitter ⚠
- p.Met4Ile Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Pro224Leu Single submitter ⚠
- p.Pro241Leu Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Ser109Leu Single submitter ⚠
- p.Ser246Leu Single submitter ⚠
- p.Ser25Pro Single submitter ⚠
- p.Ser266Arg Single submitter ⚠
- p.Ser310Phe Single submitter ⚠
- p.Ser310Tyr Single submitter ⚠
- p.Ser36Leu Single submitter ⚠
- p.Thr315Ile Single submitter ⚠
- p.Thr360Ala Single submitter ⚠
- p.Tyr172His Single submitter ⚠
- p.Val115Leu Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val21Ile Single submitter ⚠
- p.Val293Ala Single submitter ⚠
- p.Val337Ile Single submitter ⚠
- p.Val341Met Single submitter ⚠
- p.Val357Ile Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val470Met Single submitter ⚠
- p.Val69Met Single submitter ⚠
- p.Val8Ile Single submitter ⚠