CAPN11 — 107 ClinVar variants
All ClinVar germline CAPN11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
2 Benign · 7 Likely benign · 98 Uncertain significance
Full CAPN11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAPN11 p.Ala29Pro Uncertain significance Single submitter
- CAPN11 p.Ala405Pro Uncertain significance Single submitter
- CAPN11 p.Ala405Thr Uncertain significance Single submitter
- CAPN11 p.Ala461Ser Uncertain significance Single submitter
- CAPN11 p.Ala472Thr Uncertain significance Single submitter
- CAPN11 p.Ala599Thr Uncertain significance Single submitter
- CAPN11 p.Arg25Gln Uncertain significance Single submitter
- CAPN11 p.Arg25Pro Uncertain significance Single submitter
- CAPN11 p.Arg260Lys Uncertain significance Single submitter
- CAPN11 p.Arg317Gly Uncertain significance Single submitter
- CAPN11 p.Arg506Trp Uncertain significance Single submitter
- CAPN11 p.Arg513Gln Uncertain significance Single submitter
- CAPN11 p.Arg537Gly Uncertain significance Single submitter
- CAPN11 p.Arg537Trp Uncertain significance Single submitter
- CAPN11 p.Asn367Ser Uncertain significance Single submitter
- CAPN11 p.Asp240Asn Uncertain significance Single submitter
- CAPN11 p.Asp35Tyr Uncertain significance Single submitter
- CAPN11 p.Asp56Asn Uncertain significance Single submitter
- CAPN11 p.Asp653His Uncertain significance Single submitter
- CAPN11 p.Cys703Arg Uncertain significance Single submitter
- CAPN11 p.Gln458Lys Uncertain significance Single submitter
- CAPN11 p.Gly224Glu Uncertain significance Single submitter
- CAPN11 p.Gly295Trp Uncertain significance Single submitter
- CAPN11 p.Gly323Asp Uncertain significance Single submitter
- CAPN11 p.Gly356Arg Uncertain significance Single submitter
- CAPN11 p.Gly53Asp Uncertain significance Single submitter
- CAPN11 p.His391Gln Uncertain significance Single submitter
- CAPN11 p.Ile131Thr Uncertain significance Single submitter
- CAPN11 p.Leu470Pro Uncertain significance Single submitter
- CAPN11 p.Leu667Met Uncertain significance Single submitter
- CAPN11 p.Leu684Pro Uncertain significance Single submitter
- CAPN11 p.Lys166Asn Uncertain significance Single submitter
- CAPN11 p.Lys492Arg Uncertain significance Single submitter
- CAPN11 p.Lys708Gln Uncertain significance Single submitter
- CAPN11 p.Met347Thr Uncertain significance Single submitter
- CAPN11 p.Met449Arg Uncertain significance Single submitter
- CAPN11 p.Met618Thr Uncertain significance Single submitter
- CAPN11 p.Met622Leu Uncertain significance Single submitter
- CAPN11 p.Met737Leu Uncertain significance Single submitter
- CAPN11 p.Phe201Ser Uncertain significance Single submitter
- CAPN11 p.Phe415Leu Uncertain significance Single submitter
- CAPN11 p.Phe490Ser Uncertain significance Single submitter
- CAPN11 p.Phe576Leu Uncertain significance Single submitter
- CAPN11 p.Pro7Arg Uncertain significance Single submitter
- CAPN11 p.Ser19Thr Uncertain significance Single submitter
- CAPN11 p.Ser388Asn Uncertain significance Single submitter
- CAPN11 p.Ser509Arg Uncertain significance Single submitter
- CAPN11 p.Thr150Ser Uncertain significance Single submitter
- CAPN11 p.Thr36Met Uncertain significance Single submitter
- CAPN11 p.Trp416Arg Uncertain significance Single submitter
- CAPN11 p.Tyr493Cys Uncertain significance Single submitter
- CAPN11 p.Val158Gly Uncertain significance Single submitter
- CAPN11 p.Val158Met Uncertain significance Single submitter
- CAPN11 p.Val188Gly Uncertain significance Single submitter
- CAPN11 p.Val579Met Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- CAPN11 p.Ala689Glu Uncertain significance Single submitter
- CAPN11 p.Arg157His Uncertain significance Single submitter
- CAPN11 p.Arg25Trp Uncertain significance Single submitter
- CAPN11 p.Arg319Gln Uncertain significance Single submitter
- CAPN11 p.Arg319Trp Uncertain significance Single submitter
- CAPN11 p.Arg400Cys Uncertain significance Single submitter
- CAPN11 p.Arg400His Uncertain significance Single submitter
- CAPN11 p.Arg454Trp Uncertain significance Single submitter
- CAPN11 p.Arg457Gln Uncertain significance Single submitter
- CAPN11 p.Arg457Trp Uncertain significance Single submitter
- CAPN11 p.Arg46Gln Uncertain significance Single submitter
- CAPN11 p.Arg46Trp Uncertain significance Single submitter
- CAPN11 p.Arg666Cys Uncertain significance Single submitter
- CAPN11 p.Arg666His Uncertain significance Single submitter
- CAPN11 p.Arg666Leu Uncertain significance Single submitter
- CAPN11 p.Asp124Asn Likely benign Single submitter
- CAPN11 p.Asp569His Uncertain significance Single submitter
- CAPN11 p.Glu396Gln Uncertain significance Single submitter
- CAPN11 p.Glu396Val Uncertain significance Single submitter
- CAPN11 p.Glu590Gln Uncertain significance Single submitter
- CAPN11 p.Glu81Lys Uncertain significance Single submitter
- CAPN11 p.Gly237Ser Uncertain significance Single submitter
- CAPN11 p.Gly273Ala Uncertain significance Single submitter
- CAPN11 p.Gly273Cys Uncertain significance Single submitter
- CAPN11 p.Gly587Arg Uncertain significance Single submitter
- CAPN11 p.Gly626Cys Uncertain significance Single submitter
- CAPN11 p.Gly77Arg Uncertain significance Single submitter
- CAPN11 p.Ile172Val Uncertain significance Single submitter
- CAPN11 p.Ile276Thr Uncertain significance Single submitter
- CAPN11 p.Ile648Val Uncertain significance Single submitter
- CAPN11 p.Lys102Asn Uncertain significance Single submitter
- CAPN11 p.Lys48Asn Uncertain significance Single submitter
- CAPN11 p.Lys641Ile Uncertain significance Single submitter
- CAPN11 p.Lys95Glu Uncertain significance Single submitter
- CAPN11 p.Met360Leu Uncertain significance Single submitter
- CAPN11 p.Phe697Val Uncertain significance Single submitter
- CAPN11 p.Pro412Arg Uncertain significance Single submitter
- CAPN11 p.Pro83Arg Uncertain significance Single submitter
- CAPN11 p.Thr370Met Uncertain significance Single submitter
- CAPN11 p.Thr378Met Uncertain significance Single submitter
- CAPN11 p.Thr709Ile Uncertain significance Single submitter
- CAPN11 p.Tyr362His Uncertain significance Single submitter
- CAPN11 p.Val245Met Uncertain significance Single submitter
- CAPN11 p.Val441Ile Uncertain significance Single submitter
All CAPN11 variants
Likely benign 7
- p.Gln133Ter Multiple submitters
- p.Ala335Ser Single submitter
- p.Ala435Thr Single submitter
- p.Asp124Asn Single submitter ⚠
- p.His724Tyr Single submitter
- p.Ile131Val Single submitter
- p.Thr353Met Single submitter
Uncertain significance 98
- p.Ala29Pro Single submitter ⚠
- p.Ala405Pro Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Ala461Ser Single submitter ⚠
- p.Ala472Thr Single submitter ⚠
- p.Ala599Thr Single submitter ⚠
- p.Ala689Glu Single submitter ⚠
- p.Arg157His Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg25Pro Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg260Lys Single submitter ⚠
- p.Arg317Gly Single submitter ⚠
- p.Arg319Gln Single submitter ⚠
- p.Arg319Trp Single submitter ⚠
- p.Arg400Cys Single submitter ⚠
- p.Arg400His Single submitter ⚠
- p.Arg454Trp Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg457Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg506Trp Single submitter ⚠
- p.Arg513Gln Single submitter ⚠
- p.Arg537Gly Single submitter ⚠
- p.Arg537Trp Single submitter ⚠
- p.Arg666Cys Single submitter ⚠
- p.Arg666His Single submitter ⚠
- p.Arg666Leu Single submitter ⚠
- p.Asn367Ser Single submitter ⚠
- p.Asp240Asn Single submitter ⚠
- p.Asp35Tyr Single submitter ⚠
- p.Asp569His Single submitter ⚠
- p.Asp56Asn Single submitter ⚠
- p.Asp653His Single submitter ⚠
- p.Cys703Arg Single submitter ⚠
- p.Gln458Lys Single submitter ⚠
- p.Glu396Gln Single submitter ⚠
- p.Glu396Val Single submitter ⚠
- p.Glu590Gln Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.Gly224Glu Single submitter ⚠
- p.Gly237Ser Single submitter ⚠
- p.Gly273Ala Single submitter ⚠
- p.Gly273Cys Single submitter ⚠
- p.Gly295Trp Single submitter ⚠
- p.Gly323Asp Single submitter ⚠
- p.Gly356Arg Single submitter ⚠
- p.Gly53Asp Single submitter ⚠
- p.Gly587Arg Single submitter ⚠
- p.Gly626Cys Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.His391Gln Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile172Val Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Ile648Val Single submitter ⚠
- p.Leu470Pro Single submitter ⚠
- p.Leu667Met Single submitter ⚠
- p.Leu684Pro Single submitter ⚠
- p.Lys102Asn Single submitter ⚠
- p.Lys166Asn Single submitter ⚠
- p.Lys48Asn Single submitter ⚠
- p.Lys492Arg Single submitter ⚠
- p.Lys641Ile Single submitter ⚠
- p.Lys708Gln Single submitter ⚠
- p.Lys95Glu Single submitter ⚠
- p.Met347Thr Single submitter ⚠
- p.Met360Leu Single submitter ⚠
- p.Met449Arg Single submitter ⚠
- p.Met618Thr Single submitter ⚠
- p.Met622Leu Single submitter ⚠
- p.Met737Leu Single submitter ⚠
- p.Phe201Ser Single submitter ⚠
- p.Phe415Leu Single submitter ⚠
- p.Phe490Ser Single submitter ⚠
- p.Phe576Leu Single submitter ⚠
- p.Phe697Val Single submitter ⚠
- p.Pro412Arg Single submitter ⚠
- p.Pro7Arg Single submitter ⚠
- p.Pro83Arg Single submitter ⚠
- p.Ser19Thr Single submitter ⚠
- p.Ser388Asn Single submitter ⚠
- p.Ser509Arg Single submitter ⚠
- p.Thr150Ser Single submitter ⚠
- p.Thr36Met Single submitter ⚠
- p.Thr370Met Single submitter ⚠
- p.Thr378Met Single submitter ⚠
- p.Thr709Ile Single submitter ⚠
- p.Trp416Arg Single submitter ⚠
- p.Tyr362His Single submitter ⚠
- p.Tyr493Cys Single submitter ⚠
- p.Val158Gly Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val188Gly Single submitter ⚠
- p.Val245Met Single submitter ⚠
- p.Val441Ile Single submitter ⚠
- p.Val579Met Single submitter ⚠