CAPZA3 — 45 ClinVar variants
All ClinVar germline CAPZA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
45 Uncertain significance
Full CAPZA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAPZA3 p.Ala153Val Uncertain significance Single submitter
- CAPZA3 p.Ala219Val Uncertain significance Single submitter
- CAPZA3 p.Ala226Ser Uncertain significance Single submitter
- CAPZA3 p.Ala30Gly Uncertain significance Single submitter
- CAPZA3 p.Arg188Lys Uncertain significance Single submitter
- CAPZA3 p.Arg8Met Uncertain significance Single submitter
- CAPZA3 p.Arg8Ser Uncertain significance Single submitter
- CAPZA3 p.Asn159His Uncertain significance Single submitter
- CAPZA3 p.Asn234Lys Uncertain significance Single submitter
- CAPZA3 p.Asp80Asn Uncertain significance Single submitter
- CAPZA3 p.Cys123Tyr Uncertain significance Single submitter
- CAPZA3 p.Cys198Ser Uncertain significance Single submitter
- CAPZA3 p.Cys50Arg Uncertain significance Single submitter
- CAPZA3 p.Cys50Tyr Uncertain significance Single submitter
- CAPZA3 p.Gln21Pro Uncertain significance Single submitter
- CAPZA3 p.Gln245His Uncertain significance Single submitter
- CAPZA3 p.Glu161Val Uncertain significance Single submitter
- CAPZA3 p.Gly79Ser Uncertain significance Single submitter
- CAPZA3 p.His86Asp Uncertain significance Single submitter
- CAPZA3 p.Ile155Met Uncertain significance Single submitter
- CAPZA3 p.Ile203Thr Uncertain significance Single submitter
- CAPZA3 p.Ile267Thr Uncertain significance Single submitter
- CAPZA3 p.Leu223Arg Uncertain significance Single submitter
- CAPZA3 p.Leu228Phe Uncertain significance Single submitter
- CAPZA3 p.Leu266Pro Uncertain significance Single submitter
- CAPZA3 p.Leu90Phe Uncertain significance Single submitter
- CAPZA3 p.Lys148Asn Uncertain significance Single submitter
- CAPZA3 p.Lys210Gln Uncertain significance Single submitter
- CAPZA3 p.Pro134Leu Uncertain significance Single submitter
- CAPZA3 p.Ser248Pro Uncertain significance Single submitter
- CAPZA3 p.Thr144Ser Uncertain significance Single submitter
- CAPZA3 p.Thr162Lys Uncertain significance Single submitter
- CAPZA3 p.Thr263Ile Uncertain significance Single submitter
- CAPZA3 p.Thr265Ala Uncertain significance Single submitter
- CAPZA3 p.Tyr286His Uncertain significance Single submitter
- CAPZA3 p.Val240Ala Uncertain significance Single submitter
- CAPZA3 p.Val5Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CAPZA3 p.Ala124Thr Uncertain significance Single submitter
- CAPZA3 p.Arg257Gln Uncertain significance Single submitter
- CAPZA3 p.Arg258Ser Uncertain significance Single submitter
- CAPZA3 p.Arg264Leu Uncertain significance Single submitter
- CAPZA3 p.Asp40Glu Uncertain significance Single submitter
- CAPZA3 p.Ser7Arg Uncertain significance Single submitter
- CAPZA3 p.Val199Asp Uncertain significance Single submitter
All CAPZA3 variants
Uncertain significance 45
- p.Ala124Thr Single submitter ⚠
- p.Ala153Val Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala226Ser Single submitter ⚠
- p.Ala30Gly Single submitter ⚠
- p.Arg188Lys Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg258Ser Single submitter ⚠
- p.Arg264Leu Single submitter ⚠
- p.Arg8Met Single submitter ⚠
- p.Arg8Ser Single submitter ⚠
- p.Asn159His Single submitter ⚠
- p.Asn234Lys Single submitter ⚠
- p.Asp40Glu Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Cys123Tyr Single submitter ⚠
- p.Cys198Ser Single submitter ⚠
- p.Cys50Arg Single submitter ⚠
- p.Cys50Tyr Single submitter ⚠
- p.Gln21Pro Single submitter ⚠
- p.Gln245His Single submitter ⚠
- p.Glu161Val Single submitter ⚠
- p.Gly79Ser Single submitter ⚠
- p.His86Asp Single submitter ⚠
- p.Ile155Met Single submitter ⚠
- p.Ile203Thr Single submitter ⚠
- p.Ile267Thr Single submitter ⚠
- p.Leu223Arg Single submitter ⚠
- p.Leu228Phe Single submitter ⚠
- p.Leu266Pro Single submitter ⚠
- p.Leu90Phe Single submitter ⚠
- p.Lys148Asn Single submitter ⚠
- p.Lys210Gln Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Ser248Pro Single submitter ⚠
- p.Ser7Arg Single submitter ⚠
- p.Thr144Ser Single submitter ⚠
- p.Thr162Lys Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr265Ala Single submitter ⚠
- p.Tyr286His Single submitter ⚠
- p.Val199Asp Single submitter ⚠
- p.Val229Met Single submitter
- p.Val240Ala Single submitter ⚠
- p.Val5Met Single submitter ⚠