CARD10 — 194 ClinVar variants
All ClinVar germline CARD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 160 flagged for review →
1 Likely pathogenic · 21 Benign · 17 Likely benign · 155 Uncertain significance
Full CARD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 160
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 96
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARD10 p.Ala1013Thr Uncertain significance Single submitter
- CARD10 p.Ala210Ser Uncertain significance Single submitter
- CARD10 p.Ala310Thr Uncertain significance Single submitter
- CARD10 p.Ala341Thr Uncertain significance Single submitter
- CARD10 p.Ala428Val Uncertain significance Single submitter
- CARD10 p.Ala495Thr Uncertain significance Single submitter
- CARD10 p.Ala496Val Uncertain significance Single submitter
- CARD10 p.Ala541Thr Uncertain significance Single submitter
- CARD10 p.Ala631Val Uncertain significance Single submitter
- CARD10 p.Ala660Thr Uncertain significance Single submitter
- CARD10 p.Ala810Val Uncertain significance Single submitter
- CARD10 p.Ala856Val Uncertain significance Single submitter
- CARD10 p.Arg1005Cys Uncertain significance Single submitter
- CARD10 p.Arg1007Cys Uncertain significance Single submitter
- CARD10 p.Arg1024Ser Uncertain significance Single submitter
- CARD10 p.Arg162Gln Uncertain significance Single submitter
- CARD10 p.Arg184His Uncertain significance Single submitter
- CARD10 p.Arg228His Uncertain significance Single submitter
- CARD10 p.Arg243Gln Uncertain significance Single submitter
- CARD10 p.Arg252Gln Uncertain significance Single submitter
- CARD10 p.Arg368His Uncertain significance Single submitter
- CARD10 p.Arg380His Uncertain significance Single submitter
- CARD10 p.Arg424Gln Uncertain significance Single submitter
- CARD10 p.Arg52Leu Uncertain significance Single submitter
- CARD10 p.Arg601Gln Uncertain significance Single submitter
- CARD10 p.Arg634His Uncertain significance Single submitter
- CARD10 p.Arg644Thr Uncertain significance Single submitter
- CARD10 p.Arg784Gln Uncertain significance Single submitter
- CARD10 p.Arg784Pro Uncertain significance Single submitter
- CARD10 p.Arg786Gly Uncertain significance Single submitter
- CARD10 p.Arg80His Uncertain significance Single submitter
- CARD10 p.Arg832Gly Uncertain significance Single submitter
- CARD10 p.Arg858Trp Uncertain significance Single submitter
- CARD10 p.Arg930Trp Uncertain significance Single submitter
- CARD10 p.Asn517Ser Uncertain significance Single submitter
- CARD10 p.Asn595His Uncertain significance Single submitter
- CARD10 p.Asn765Thr Uncertain significance Single submitter
- CARD10 p.Asp278Glu Uncertain significance Single submitter
- CARD10 p.Asp330Asn Uncertain significance Single submitter
- CARD10 p.Cys463Tyr Uncertain significance Single submitter
- CARD10 p.Gln180Leu Uncertain significance Single submitter
- CARD10 p.Gln650Arg Uncertain significance Single submitter
- CARD10 p.Gln776Arg Uncertain significance Single submitter
- CARD10 p.Glu345Lys Uncertain significance Single submitter
- CARD10 p.Glu432Asp Uncertain significance Single submitter
- CARD10 p.Glu582Val Uncertain significance Single submitter
- CARD10 p.Glu665Gln Uncertain significance Single submitter
- CARD10 p.Glu665Lys Uncertain significance Single submitter
- CARD10 p.Glu936Asp Uncertain significance Single submitter
- CARD10 p.Glu936Lys Uncertain significance Single submitter
- CARD10 p.Gly15Glu Uncertain significance Single submitter
- CARD10 p.Gly3Ala Uncertain significance Single submitter
- CARD10 p.Gly456Val Uncertain significance Single submitter
- CARD10 p.Gly500Arg Uncertain significance Single submitter
- CARD10 p.Gly529Ser Uncertain significance Single submitter
- CARD10 p.Gly588Asp Uncertain significance Single submitter
- CARD10 p.Gly590Asp Uncertain significance Single submitter
- CARD10 p.Gly761Val Uncertain significance Single submitter
- CARD10 p.Gly905Ala Uncertain significance Single submitter
- CARD10 p.His692Tyr Uncertain significance Single submitter
- CARD10 p.His992Arg Uncertain significance Single submitter
- CARD10 p.Ile553Val Uncertain significance Single submitter
- CARD10 p.Leu352Arg Uncertain significance Single submitter
- CARD10 p.Leu637Pro Uncertain significance Single submitter
- CARD10 p.Leu81Val Uncertain significance Single submitter
- CARD10 p.Leu85Phe Uncertain significance Single submitter
- CARD10 p.Leu863Val Uncertain significance Single submitter
- CARD10 p.Leu886Val Uncertain significance Single submitter
- CARD10 p.Lys544Glu Uncertain significance Single submitter
- CARD10 p.Lys616Arg Uncertain significance Single submitter
- CARD10 p.Lys686Gln Uncertain significance Single submitter
- CARD10 p.Met381Val Uncertain significance Single submitter
- CARD10 p.Phe623Cys Uncertain significance Single submitter
- CARD10 p.Pro257Leu Uncertain significance Single submitter
- CARD10 p.Pro259Arg Uncertain significance Single submitter
- CARD10 p.Pro2Arg Uncertain significance Single submitter
- CARD10 p.Pro311Leu Uncertain significance Single submitter
- CARD10 p.Pro543His Uncertain significance Single submitter
- CARD10 p.Pro543Thr Uncertain significance Single submitter
- CARD10 p.Pro581Leu Uncertain significance Single submitter
- CARD10 p.Pro611Leu Uncertain significance Single submitter
- CARD10 p.Pro781Ser Uncertain significance Single submitter
- CARD10 p.Pro816Leu Uncertain significance Single submitter
- CARD10 p.Pro827Leu Uncertain significance Single submitter
- CARD10 p.Ser222Leu Uncertain significance Single submitter
- CARD10 p.Ser506Leu Uncertain significance Single submitter
- CARD10 p.Ser622Leu Uncertain significance Single submitter
- CARD10 p.Thr476Ser Uncertain significance Single submitter
- CARD10 p.Thr558Ile Uncertain significance Single submitter
- CARD10 p.Thr678Ile Uncertain significance Single submitter
- CARD10 p.Tyr624His Uncertain significance Single submitter
- CARD10 p.Tyr93Cys Uncertain significance Single submitter
- CARD10 p.Val449Phe Uncertain significance Single submitter
- CARD10 p.Val75Ile Uncertain significance Single submitter
- CARD10 p.Val951Ile Uncertain significance Single submitter
-
CARD10 p.Ala1032Asp
Uncertain significance
No assertion criteria
CARD10-related disorder
Predictors split 64
The independent predictors disagree with each other — read with care.
-
CARD10 p.Thr436Met
Uncertain significance
Multiple submitters
immunodeficiency 89 and autoimmunity
- CARD10 p.Ala10Val Uncertain significance Single submitter
- CARD10 p.Ala159Val Uncertain significance Single submitter
- CARD10 p.Ala285Gly Uncertain significance Single submitter
- CARD10 p.Ala292Val Uncertain significance Single submitter
- CARD10 p.Ala654Thr Uncertain significance Single submitter
- CARD10 p.Arg1014His Uncertain significance Single submitter
- CARD10 p.Arg142Gln Uncertain significance Single submitter
- CARD10 p.Arg160Trp Uncertain significance Single submitter
- CARD10 p.Arg174Trp Uncertain significance Single submitter
- CARD10 p.Arg184Cys Uncertain significance Single submitter
- CARD10 p.Arg189Trp Uncertain significance Single submitter
- CARD10 p.Arg201Gln Uncertain significance Single submitter
- CARD10 p.Arg212Cys Uncertain significance Single submitter
- CARD10 p.Arg284Cys Uncertain significance Single submitter
- CARD10 p.Arg289Trp Uncertain significance Single submitter
- CARD10 p.Arg307Trp Uncertain significance Single submitter
- CARD10 p.Arg364Trp Uncertain significance Single submitter
-
CARD10 p.Arg420Cys
Likely pathogenic
Single submitter
immunodeficiency 89 and autoimmunity
- CARD10 p.Arg518Gln Uncertain significance Single submitter
- CARD10 p.Arg536Cys Uncertain significance Single submitter
- CARD10 p.Arg601Trp Uncertain significance Single submitter
- CARD10 p.Arg605Trp Likely benign Single submitter
- CARD10 p.Arg634Cys Uncertain significance Single submitter
- CARD10 p.Arg733Gln Uncertain significance Single submitter
- CARD10 p.Arg784Trp Uncertain significance Single submitter
- CARD10 p.Arg789His Uncertain significance Single submitter
- CARD10 p.Arg801Trp Uncertain significance Single submitter
- CARD10 p.Arg970Trp Uncertain significance Single submitter
- CARD10 p.Arg973His Uncertain significance Single submitter
- CARD10 p.Cys1020Tyr Uncertain significance Single submitter
-
CARD10 p.Gln288Pro
Uncertain significance
Single submitter
immunodeficiency 89 and autoimmunity
- CARD10 p.Glu12Lys Uncertain significance Single submitter
- CARD10 p.Glu130Gln Uncertain significance Single submitter
- CARD10 p.Glu24Gly Uncertain significance Single submitter
- CARD10 p.Glu744Gln Uncertain significance Single submitter
- CARD10 p.Glu885Lys Uncertain significance Single submitter
- CARD10 p.Glu913Lys Uncertain significance Single submitter
- CARD10 p.Ile553Met Uncertain significance Single submitter
- CARD10 p.Ile57Met Uncertain significance Single submitter
- CARD10 p.Leu202Phe Uncertain significance Single submitter
- CARD10 p.Leu559Phe Uncertain significance Single submitter
- CARD10 p.Leu578Phe Uncertain significance Single submitter
- CARD10 p.Leu922Met Uncertain significance Single submitter
- CARD10 p.Leu922Val Uncertain significance Single submitter
- CARD10 p.Met122Ile Uncertain significance Single submitter
- CARD10 p.Phe707Val Uncertain significance Single submitter
- CARD10 p.Pro308Leu Uncertain significance Single submitter
- CARD10 p.Pro525Ala Uncertain significance Single submitter
- CARD10 p.Pro752Ser Uncertain significance Single submitter
- CARD10 p.Pro902Leu Uncertain significance Single submitter
- CARD10 p.Pro961Leu Uncertain significance Single submitter
- CARD10 p.Ser638Phe Uncertain significance Single submitter
- CARD10 p.Thr109Met Uncertain significance Single submitter
- CARD10 p.Thr369Met Uncertain significance Single submitter
- CARD10 p.Tyr766Asn Uncertain significance Single submitter
- CARD10 p.Tyr938Cys Uncertain significance Single submitter
- CARD10 p.Val497Ile Uncertain significance Single submitter
- CARD10 p.Val763Met Uncertain significance Single submitter
- CARD10 p.Val951Ala Uncertain significance Single submitter
-
CARD10 p.Arg289Gln
Benign
No assertion criteria
CARD10-related disorder
-
CARD10 p.Cys1026Tyr
Benign
No assertion criteria
CARD10-related disorder
-
CARD10 p.Glu1019Gln
Uncertain significance
No assertion criteria
CARD10-related disorder
-
CARD10 p.Glu705Lys
Benign
No assertion criteria
CARD10-related disorder
All CARD10 variants
Likely pathogenic 1
- p.Arg420Cys Single submitter immunodeficiency 89 and autoimmunity ⚠
Benign 21
- p.Ala382Thr Multiple submitters
- p.Ile940= Multiple submitters
- p.Lys514Arg Multiple submitters
- p.Thr383= Multiple submitters
- c.1065+6G>T Single submitter
- p.Thr436= Single submitter
- c.910-6C>T No assertion criteria CARD10-related disorder
- p.264KE[4] No assertion criteria CARD10-related disorder
- p.Ala528= No assertion criteria CARD10-related disorder
- p.Arg289Gln No assertion criteria CARD10-related disorder ⚠
- p.Asn517= No assertion criteria CARD10-related disorder
- p.Cys1026Tyr No assertion criteria CARD10-related disorder ⚠
- p.Cys463= No assertion criteria CARD10-related disorder
- p.Glu21= No assertion criteria CARD10-related disorder
- p.Glu273_Pro274insLysGlu No assertion criteria CARD10-related disorder
- p.Glu705Lys No assertion criteria CARD10-related disorder ⚠
- p.His36= No assertion criteria CARD10-related disorder
- p.Pro839= No assertion criteria CARD10-related disorder
- p.Ser466= No assertion criteria CARD10-related disorder
- p.Ser480= No assertion criteria CARD10-related disorder
- p.Val449= No assertion criteria CARD10-related disorder
Likely benign 17
- p.Arg605Trp Single submitter ⚠
- p.Arg768= Single submitter
- p.Asn276= Single submitter
- p.Glu327= Single submitter
- p.His943= Single submitter
- p.Pro501Ser Single submitter
- p.Val1004= Single submitter
- p.Val277Ala Single submitter
- p.Val652Ala Single submitter
- c.1383+6C>T No assertion criteria CARD10-related disorder
- c.1383+7G>A No assertion criteria CARD10-related disorder
- c.2477-7G>C No assertion criteria CARD10-related disorder
- p.Ala7= No assertion criteria CARD10-related disorder
- p.Ala704= No assertion criteria CARD10-related disorder
- p.Gln743= No assertion criteria CARD10-related disorder
- p.Glu154= No assertion criteria CARD10-related disorder
- p.Ser622= No assertion criteria CARD10-related disorder
Uncertain significance 155
- p.Thr436Met Multiple submitters immunodeficiency 89 and autoimmunity ⚠
- p.Ala1013Thr Single submitter ⚠
- p.Ala10Val Single submitter ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala210Ser Single submitter ⚠
- p.Ala285Gly Single submitter ⚠
- p.Ala292Val Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala428Val Single submitter ⚠
- p.Ala495Thr Single submitter ⚠
- p.Ala496Val Single submitter ⚠
- p.Ala541Thr Single submitter ⚠
- p.Ala631Val Single submitter ⚠
- p.Ala654Thr Single submitter ⚠
- p.Ala660Thr Single submitter ⚠
- p.Ala810Val Single submitter ⚠
- p.Ala856Val Single submitter ⚠
- p.Arg1005Cys Single submitter ⚠
- p.Arg1007Cys Single submitter ⚠
- p.Arg1014His Single submitter ⚠
- p.Arg1024Ser Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg189Trp Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg252Gln Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg289Trp Single submitter ⚠
- p.Arg307Trp Single submitter ⚠
- p.Arg364Trp Single submitter ⚠
- p.Arg368His Single submitter ⚠
- p.Arg380His Single submitter ⚠
- p.Arg424Gln Single submitter ⚠
- p.Arg518Gln Single submitter ⚠
- p.Arg52Leu Single submitter ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg601Gln Single submitter ⚠
- p.Arg601Trp Single submitter ⚠
- p.Arg634Cys Single submitter ⚠
- p.Arg634His Single submitter ⚠
- p.Arg644Thr Single submitter ⚠
- p.Arg733Gln Single submitter ⚠
- p.Arg784Gln Single submitter ⚠
- p.Arg784Pro Single submitter ⚠
- p.Arg784Trp Single submitter ⚠
- p.Arg786Gly Single submitter ⚠
- p.Arg789His Single submitter ⚠
- p.Arg801Trp Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Arg832Gly Single submitter ⚠
- p.Arg858Trp Single submitter ⚠
- p.Arg930Trp Single submitter ⚠
- p.Arg970Trp Single submitter ⚠
- p.Arg973His Single submitter ⚠
- p.Asn517Ser Single submitter ⚠
- p.Asn595His Single submitter ⚠
- p.Asn765Thr Single submitter ⚠
- p.Asp278Glu Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Cys1020Tyr Single submitter ⚠
- p.Cys463Tyr Single submitter ⚠
- p.Gln180Leu Single submitter ⚠
- p.Gln288Pro Single submitter immunodeficiency 89 and autoimmunity ⚠
- p.Gln650Arg Single submitter ⚠
- p.Gln776Arg Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu130Gln Single submitter ⚠
- p.Glu24Gly Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Glu432Asp Single submitter ⚠
- p.Glu582Val Single submitter ⚠
- p.Glu665Gln Single submitter ⚠
- p.Glu665Lys Single submitter ⚠
- p.Glu744Gln Single submitter ⚠
- p.Glu885Lys Single submitter ⚠
- p.Glu913Lys Single submitter ⚠
- p.Glu936Asp Single submitter ⚠
- p.Glu936Lys Single submitter ⚠
- p.Gly15Glu Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.Gly456Val Single submitter ⚠
- p.Gly500Arg Single submitter ⚠
- p.Gly529Ser Single submitter ⚠
- p.Gly588Asp Single submitter ⚠
- p.Gly590Asp Single submitter ⚠
- p.Gly761Val Single submitter ⚠
- p.Gly905Ala Single submitter ⚠
- p.His692Tyr Single submitter ⚠
- p.His992Arg Single submitter ⚠
- p.Ile553Met Single submitter ⚠
- p.Ile553Val Single submitter ⚠
- p.Ile57Met Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu352Arg Single submitter ⚠
- p.Leu559Phe Single submitter ⚠
- p.Leu578Phe Single submitter ⚠
- p.Leu637Pro Single submitter ⚠
- p.Leu81Val Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Leu863Val Single submitter ⚠
- p.Leu886Val Single submitter ⚠
- p.Leu922Met Single submitter ⚠
- p.Leu922Val Single submitter ⚠
- p.Lys544Glu Single submitter ⚠
- p.Lys616Arg Single submitter ⚠
- p.Lys686Gln Single submitter ⚠
- p.Met122Ile Single submitter ⚠
- p.Met381Val Single submitter ⚠
- p.Phe623Cys Single submitter ⚠
- p.Phe707Val Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro259Arg Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Pro308Leu Single submitter ⚠
- p.Pro311Leu Single submitter ⚠
- p.Pro525Ala Single submitter ⚠
- p.Pro543His Single submitter ⚠
- p.Pro543Thr Single submitter ⚠
- p.Pro581Leu Single submitter ⚠
- p.Pro611Leu Single submitter ⚠
- p.Pro752Ser Single submitter ⚠
- p.Pro781Ser Single submitter ⚠
- p.Pro816Leu Single submitter ⚠
- p.Pro827Leu Single submitter ⚠
- p.Pro902Leu Single submitter ⚠
- p.Pro961Leu Single submitter ⚠
- p.Ser222Leu Single submitter ⚠
- p.Ser506Leu Single submitter ⚠
- p.Ser622Leu Single submitter ⚠
- p.Ser638Phe Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr369Met Single submitter ⚠
- p.Thr476Ser Single submitter ⚠
- p.Thr558Ile Single submitter ⚠
- p.Thr678Ile Single submitter ⚠
- p.Tyr624His Single submitter ⚠
- p.Tyr766Asn Single submitter ⚠
- p.Tyr938Cys Single submitter ⚠
- p.Tyr93Cys Single submitter ⚠
- p.Val449Phe Single submitter ⚠
- p.Val497Ile Single submitter ⚠
- p.Val75Ile Single submitter ⚠
- p.Val763Met Single submitter ⚠
- p.Val951Ala Single submitter ⚠
- p.Val951Ile Single submitter ⚠
- p.Ala1032Asp No assertion criteria CARD10-related disorder ⚠
- p.Glu1019Gln No assertion criteria CARD10-related disorder ⚠