CARD16 — 19 ClinVar variants
All ClinVar germline CARD16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
19 Uncertain significance
Full CARD16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARD16 c.*174T>G Uncertain significance Single submitter
- CARD16 c.*186G>C Uncertain significance Single submitter
- CARD16 c.*56T>C Uncertain significance Single submitter
- CARD16 c.*61G>C Uncertain significance Single submitter
- CARD16 c.*67C>G Uncertain significance Single submitter
- CARD16 p.Ala48Ser Uncertain significance Single submitter
- CARD16 p.His15Leu Uncertain significance Single submitter
- CARD16 p.Leu57Ser Uncertain significance Single submitter
- CARD16 p.Tyr82Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CARD16 p.Arg45His Uncertain significance Single submitter
- CARD16 p.Arg55Gln Uncertain significance Single submitter
- CARD16 p.Asp59Asn Uncertain significance Single submitter
- CARD16 p.Gln37Lys Uncertain significance Single submitter
- CARD16 p.Glu39Gln Uncertain significance Single submitter
- CARD16 p.Ile62Thr Uncertain significance Single submitter
- CARD16 p.Pro63Leu Uncertain significance Single submitter
- CARD16 p.Ser16Tyr Uncertain significance Single submitter
- CARD16 p.Ser81Gly Uncertain significance Single submitter
- CARD16 p.Thr54Asn Uncertain significance Single submitter
All CARD16 variants
Uncertain significance 19
- c.*174T>G Single submitter ⚠
- c.*186G>C Single submitter ⚠
- c.*56T>C Single submitter ⚠
- c.*61G>C Single submitter ⚠
- c.*67C>G Single submitter ⚠
- p.Ala48Ser Single submitter ⚠
- p.Arg45His Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Asp59Asn Single submitter ⚠
- p.Gln37Lys Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.His15Leu Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Leu57Ser Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser16Tyr Single submitter ⚠
- p.Ser81Gly Single submitter ⚠
- p.Thr54Asn Single submitter ⚠
- p.Tyr82Cys Single submitter ⚠