CARD18 — 13 ClinVar variants
All ClinVar germline CARD18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
13 Uncertain significance
Full CARD18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- CARD18 p.Ala2Val Uncertain significance Single submitter
- CARD18 p.Ala54Ser Uncertain significance Single submitter
- CARD18 p.Arg10Gly Uncertain significance Single submitter
- CARD18 p.Ile35Thr Uncertain significance Single submitter
- CARD18 p.Leu26Pro Uncertain significance Single submitter
- CARD18 p.Leu30Ile Uncertain significance Single submitter
- CARD18 p.Leu76Phe Uncertain significance Single submitter
- CARD18 p.Lys53Glu Uncertain significance Single submitter
- CARD18 p.Met40Thr Uncertain significance Single submitter
- CARD18 p.Ser36Ile Uncertain significance Single submitter
All CARD18 variants
Uncertain significance 13
- p.Ala19Ser Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala54Ser Single submitter ⚠
- p.Arg10Gly Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Leu30Ile Single submitter ⚠
- p.Leu60Phe Single submitter ⚠
- p.Leu76Phe Single submitter ⚠
- p.Lys53Glu Single submitter ⚠
- p.Met40Thr Single submitter ⚠
- p.Ser36Ile Single submitter ⚠
- p.Val50Asp Single submitter ⚠