CARD19 — 36 ClinVar variants
All ClinVar germline CARD19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 35 Uncertain significance
Full CARD19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARD19 p.Ala83Asp Uncertain significance Single submitter
- CARD19 p.Arg22Cys Uncertain significance Single submitter
- CARD19 p.Arg52Trp Uncertain significance Single submitter
- CARD19 p.Arg61Trp Uncertain significance Single submitter
- CARD19 p.Arg94His Uncertain significance Single submitter
- CARD19 p.Arg94Leu Uncertain significance Single submitter
- CARD19 p.Arg9Cys Uncertain significance Single submitter
- CARD19 p.His68Tyr Uncertain significance Single submitter
- CARD19 p.Lys55Arg Uncertain significance Single submitter
- CARD19 p.Val60Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CARD19 p.Arg52Gln Uncertain significance Single submitter
- CARD19 p.Arg59Cys Uncertain significance Single submitter
- CARD19 p.Arg59Ser Uncertain significance Single submitter
- CARD19 p.Arg75Pro Uncertain significance Single submitter
- CARD19 p.Arg75Trp Uncertain significance Single submitter
- CARD19 p.Arg98His Uncertain significance Single submitter
- CARD19 p.Gln41His Uncertain significance Single submitter
- CARD19 p.Leu43Val Uncertain significance Single submitter
- CARD19 p.Ser24Arg Uncertain significance Single submitter
- CARD19 p.Thr14Met Uncertain significance Single submitter
- CARD19 p.Thr5Pro Uncertain significance Single submitter
All CARD19 variants
Likely benign 1
- p.Ala48= Single submitter
Uncertain significance 35
- p.Ala83Asp Single submitter ⚠
- p.Arg121Lys Single submitter
- p.Arg155Ser Single submitter
- p.Arg166Thr Single submitter
- p.Arg170His Single submitter
- p.Arg170Pro Single submitter
- p.Arg22Cys Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg59Ser Single submitter ⚠
- p.Arg61Trp Single submitter ⚠
- p.Arg75Pro Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Arg94Leu Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Arg9Cys Single submitter ⚠
- p.Asp178Val Single submitter
- p.Gln114Pro Single submitter
- p.Gln41His Single submitter ⚠
- p.Gly158Ser Single submitter
- p.Gly181Ala Single submitter
- p.His68Tyr Single submitter ⚠
- p.Leu183Phe Single submitter
- p.Leu43Val Single submitter ⚠
- p.Lys55Arg Single submitter ⚠
- p.Met124Arg Single submitter
- p.Met124Lys Single submitter
- p.Ser160Leu Single submitter
- p.Ser24Arg Single submitter ⚠
- p.Thr14Met Single submitter ⚠
- p.Thr5Pro Single submitter ⚠
- p.Val156Ile Single submitter
- p.Val60Leu Single submitter ⚠