CARF — 101 ClinVar variants
All ClinVar germline CARF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
6 Benign · 11 Likely benign · 84 Uncertain significance
Full CARF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARF p.Gln640Pro Uncertain significance Multiple submitters
- CARF p.Ala629Val Uncertain significance Single submitter
- CARF p.Arg221His Uncertain significance Single submitter
- CARF p.Arg318Trp Uncertain significance Single submitter
- CARF p.Arg52Cys Uncertain significance Single submitter
- CARF p.Asn111Ser Uncertain significance Single submitter
- CARF p.Asn11Thr Uncertain significance Single submitter
- CARF p.Asp14Gly Uncertain significance Single submitter
- CARF p.Asp160Gly Uncertain significance Single submitter
- CARF p.Asp35Asn Uncertain significance Single submitter
- CARF p.Asp35Val Uncertain significance Single submitter
- CARF p.Gln127Lys Uncertain significance Single submitter
- CARF p.Gln309Arg Uncertain significance Single submitter
- CARF p.Gln617Pro Uncertain significance Single submitter
- CARF p.Glu16Lys Uncertain significance Single submitter
- CARF p.Glu576Lys Uncertain significance Single submitter
- CARF p.Glu647Lys Uncertain significance Single submitter
- CARF p.Glu76Asp Uncertain significance Single submitter
- CARF p.Glu76Gly Uncertain significance Single submitter
- CARF p.Gly652Glu Uncertain significance Single submitter
- CARF p.His172Leu Uncertain significance Single submitter
- CARF p.His79Arg Uncertain significance Single submitter
- CARF p.Ile130Thr Uncertain significance Single submitter
- CARF p.Ile343Thr Uncertain significance Single submitter
- CARF p.Ile598Thr Uncertain significance Single submitter
- CARF p.Ile675Val Uncertain significance Single submitter
- CARF p.Leu115Ile Uncertain significance Single submitter
- CARF p.Leu354Pro Uncertain significance Single submitter
- CARF p.Leu608Ile Uncertain significance Single submitter
- CARF p.Leu709Phe Uncertain significance Single submitter
- CARF p.Leu8Ser Uncertain significance Single submitter
- CARF p.Lys326Gln Uncertain significance Single submitter
- CARF p.Lys715Arg Uncertain significance Single submitter
- CARF p.Lys715Thr Uncertain significance Single submitter
- CARF p.Lys720Glu Uncertain significance Single submitter
- CARF p.Lys721Glu Uncertain significance Single submitter
- CARF p.Met125Lys Uncertain significance Single submitter
- CARF p.Phe517Leu Uncertain significance Single submitter
- CARF p.Pro178Leu Uncertain significance Single submitter
- CARF p.Pro316Leu Uncertain significance Single submitter
- CARF p.Pro66Leu Uncertain significance Single submitter
- CARF p.Pro691Ser Uncertain significance Single submitter
- CARF p.Pro707Ser Uncertain significance Single submitter
- CARF p.Ser243Asn Uncertain significance Single submitter
- CARF p.Ser723Ala Uncertain significance Single submitter
- CARF p.Thr156Ala Uncertain significance Single submitter
- CARF p.Thr516Pro Uncertain significance Single submitter
- CARF p.Thr572Ile Uncertain significance Single submitter
- CARF p.Thr623Ser Uncertain significance Single submitter
- CARF p.Thr657Ile Uncertain significance Single submitter
- CARF p.Thr70Ala Uncertain significance Single submitter
- CARF p.Trp206Arg Uncertain significance Single submitter
- CARF p.Trp245Cys Uncertain significance Single submitter
- CARF p.Tyr320His Uncertain significance Single submitter
- CARF p.Tyr437Ser Uncertain significance Single submitter
- CARF p.Val157Leu Uncertain significance Single submitter
- CARF p.Val159Met Uncertain significance Single submitter
- CARF p.Val359Ile Uncertain significance Single submitter
- CARF p.Val369Leu Uncertain significance Single submitter
- CARF p.Val515Ile Uncertain significance Single submitter
- CARF p.Val602Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CARF p.Arg142Trp Uncertain significance Single submitter
- CARF p.Arg666Trp Uncertain significance Single submitter
- CARF p.Asn84Lys Uncertain significance Single submitter
- CARF p.Gln127Glu Uncertain significance Single submitter
- CARF p.Gln132Arg Uncertain significance Single submitter
- CARF p.Gln240Lys Uncertain significance Single submitter
- CARF p.Glu478Gly Uncertain significance Single submitter
- CARF p.Gly112Glu Uncertain significance Single submitter
- CARF p.Gly294Ser Uncertain significance Single submitter
- CARF p.Gly662Arg Uncertain significance Single submitter
- CARF p.Gly96Arg Uncertain significance Single submitter
- CARF p.Leu210Ile Uncertain significance Single submitter
- CARF p.Leu635Phe Uncertain significance Single submitter
- CARF p.Leu67Arg Uncertain significance Single submitter
- CARF p.Lys238Glu Uncertain significance Single submitter
- CARF p.Pro108Leu Uncertain significance Single submitter
- CARF p.Pro328Leu Uncertain significance Single submitter
- CARF p.Pro385Arg Uncertain significance Single submitter
- CARF p.Ser219Ala Uncertain significance Single submitter
- CARF p.Ser615Arg Uncertain significance Single submitter
- CARF p.Thr258Ala Uncertain significance Single submitter
- CARF p.Tyr90His Uncertain significance Single submitter
- CARF p.Val282Ala Uncertain significance Single submitter
All CARF variants
Benign 6
- c.*377G>A Multiple submitters
- p.Pro454= Multiple submitters
- p.Thr725Ala Multiple submitters
- c.954-6A>T Single submitter
- p.Gly506= Single submitter
- p.Pro587Leu Single submitter
Likely benign 11
- p.Pro108Ser Multiple submitters
- p.Thr716fs Multiple submitters
- p.Val157Ala Multiple submitters
- p.Arg142Gln Single submitter
- p.Arg52His Single submitter
- p.Arg666Gln Single submitter
- p.Gly186Arg Single submitter
- p.Ile527Val Single submitter
- p.Met513Val Single submitter
- p.Thr161Ala Single submitter
- p.Thr545Ala Single submitter
Uncertain significance 84
- p.Gln640Pro Multiple submitters ⚠
- p.Ala629Val Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Arg52Cys Single submitter ⚠
- p.Arg666Trp Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asn11Thr Single submitter ⚠
- p.Asn84Lys Single submitter ⚠
- p.Asp14Gly Single submitter ⚠
- p.Asp160Gly Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Asp35Val Single submitter ⚠
- p.Gln127Glu Single submitter ⚠
- p.Gln127Lys Single submitter ⚠
- p.Gln132Arg Single submitter ⚠
- p.Gln240Lys Single submitter ⚠
- p.Gln309Arg Single submitter ⚠
- p.Gln617Pro Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu478Gly Single submitter ⚠
- p.Glu576Lys Single submitter ⚠
- p.Glu647Lys Single submitter ⚠
- p.Glu76Asp Single submitter ⚠
- p.Glu76Gly Single submitter ⚠
- p.Gly112Glu Single submitter ⚠
- p.Gly294Ser Single submitter ⚠
- p.Gly652Glu Single submitter ⚠
- p.Gly662Arg Single submitter ⚠
- p.Gly96Arg Single submitter ⚠
- p.His172Leu Single submitter ⚠
- p.His79Arg Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile343Thr Single submitter ⚠
- p.Ile598Thr Single submitter ⚠
- p.Ile675Val Single submitter ⚠
- p.Leu115Ile Single submitter ⚠
- p.Leu210Ile Single submitter ⚠
- p.Leu354Pro Single submitter ⚠
- p.Leu608Ile Single submitter ⚠
- p.Leu635Phe Single submitter ⚠
- p.Leu67Arg Single submitter ⚠
- p.Leu709Phe Single submitter ⚠
- p.Leu8Ser Single submitter ⚠
- p.Lys238Glu Single submitter ⚠
- p.Lys326Gln Single submitter ⚠
- p.Lys715Arg Single submitter ⚠
- p.Lys715Thr Single submitter ⚠
- p.Lys720Glu Single submitter ⚠
- p.Lys721Glu Single submitter ⚠
- p.Met125Lys Single submitter ⚠
- p.Phe517Leu Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro316Leu Single submitter ⚠
- p.Pro328Leu Single submitter ⚠
- p.Pro385Arg Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Pro691Ser Single submitter ⚠
- p.Pro707Ser Single submitter ⚠
- p.Ser219Ala Single submitter ⚠
- p.Ser243Asn Single submitter ⚠
- p.Ser615Arg Single submitter ⚠
- p.Ser723Ala Single submitter ⚠
- p.Thr156Ala Single submitter ⚠
- p.Thr258Ala Single submitter ⚠
- p.Thr516Pro Single submitter ⚠
- p.Thr572Ile Single submitter ⚠
- p.Thr623Ser Single submitter ⚠
- p.Thr657Ile Single submitter ⚠
- p.Thr70Ala Single submitter ⚠
- p.Trp206Arg Single submitter ⚠
- p.Trp245Cys Single submitter ⚠
- p.Tyr320His Single submitter ⚠
- p.Tyr437Ser Single submitter ⚠
- p.Tyr90His Single submitter ⚠
- p.Val157Leu Single submitter ⚠
- p.Val159Met Single submitter ⚠
- p.Val282Ala Single submitter ⚠
- p.Val359Ile Single submitter ⚠
- p.Val369Leu Single submitter ⚠
- p.Val515Ile Single submitter ⚠
- p.Val602Leu Single submitter ⚠