CARM1 — 49 ClinVar variants
All ClinVar germline CARM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 4 Likely benign · 44 Uncertain significance
Full CARM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARM1 p.Ala15Val Uncertain significance Single submitter
- CARM1 p.Ala212Thr Uncertain significance Single submitter
- CARM1 p.Ala428Thr Uncertain significance Single submitter
- CARM1 p.Ala525Val Uncertain significance Single submitter
- CARM1 p.Ala55Glu Uncertain significance Single submitter
- CARM1 p.Ala566Thr Uncertain significance Single submitter
- CARM1 p.Ala62Ser Uncertain significance Single submitter
- CARM1 p.Ala7Thr Uncertain significance Single submitter
- CARM1 p.Ala7Val Uncertain significance Single submitter
- CARM1 p.Arg134Gln Uncertain significance Single submitter
- CARM1 p.Gly565Ser Uncertain significance Single submitter
- CARM1 p.Gly63Ser Uncertain significance Single submitter
- CARM1 p.Gly68Val Uncertain significance Single submitter
- CARM1 p.His130Tyr Uncertain significance Single submitter
- CARM1 p.Met597Thr Uncertain significance Single submitter
- CARM1 p.Pro25Arg Uncertain significance Single submitter
- CARM1 p.Pro25Leu Uncertain significance Single submitter
- CARM1 p.Pro537Ala Uncertain significance Single submitter
- CARM1 p.Ser66Leu Uncertain significance Single submitter
- CARM1 p.Ser73Asn Uncertain significance Single submitter
- CARM1 p.Thr39Ser Uncertain significance Single submitter
- CARM1 p.Thr574Met Uncertain significance Single submitter
- CARM1 p.Thr585Ala Uncertain significance Single submitter
- CARM1 p.Tyr121Phe Uncertain significance Single submitter
- CARM1 p.Val107Ile Uncertain significance Single submitter
- CARM1 p.Val511Gly Uncertain significance Single submitter
- CARM1 p.Val511Met Uncertain significance Single submitter
- CARM1 p.Val530Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CARM1 p.Ala202Ser Uncertain significance Single submitter
- CARM1 p.Arg128Trp Uncertain significance Single submitter
- CARM1 p.Arg346Gln Uncertain significance Single submitter
- CARM1 p.Arg550Gly Uncertain significance Single submitter
- CARM1 p.Glu87Lys Uncertain significance Single submitter
- CARM1 p.Gly460Ser Uncertain significance Single submitter
- CARM1 p.Leu71Phe Uncertain significance Single submitter
- CARM1 p.Lys81Thr Uncertain significance Single submitter
- CARM1 p.Phe427Leu Uncertain significance Single submitter
- CARM1 p.Ser493Leu Uncertain significance Single submitter
-
CARM1 p.Thr141Ala
Uncertain significance
Single submitter
neurodevelopmental disorder
- CARM1 p.Thr433Met Uncertain significance Single submitter
- CARM1 p.Trp497Cys Uncertain significance Single submitter
- CARM1 p.Val147Leu Uncertain significance Single submitter
All CARM1 variants
Benign 1
- p.Val226= Multiple submitters
Likely benign 4
- p.Ala329= Single submitter
- p.Gly570Ser Single submitter
- p.Thr28Ala Single submitter
- p.Thr574= Single submitter
Uncertain significance 44
- p.Ala15Val Single submitter ⚠
- p.Ala202Ser Single submitter ⚠
- p.Ala212Thr Single submitter ⚠
- p.Ala428Thr Single submitter ⚠
- p.Ala525Val Single submitter ⚠
- p.Ala55Glu Single submitter ⚠
- p.Ala566Thr Single submitter ⚠
- p.Ala62Ser Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg128Trp Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg550Gly Single submitter ⚠
- p.Cys127Phe Single submitter
- p.Glu87Lys Single submitter ⚠
- p.Gly460Ser Single submitter ⚠
- p.Gly565Ser Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Gly68Val Single submitter ⚠
- p.His130Tyr Single submitter ⚠
- p.Leu71Phe Single submitter ⚠
- p.Lys81Thr Single submitter ⚠
- p.Met597Thr Single submitter ⚠
- p.Phe427Leu Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro537Ala Single submitter ⚠
- p.Ser493Leu Single submitter ⚠
- p.Ser66Leu Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Thr141Ala Single submitter neurodevelopmental disorder ⚠
- p.Thr39Ser Single submitter ⚠
- p.Thr433Met Single submitter ⚠
- p.Thr574Met Single submitter ⚠
- p.Thr585Ala Single submitter ⚠
- p.Trp497Cys Single submitter ⚠
- p.Tyr121Phe Single submitter ⚠
- p.Tyr448Ter Single submitter
- p.Val107Ile Single submitter ⚠
- p.Val147Leu Single submitter ⚠
- p.Val511Gly Single submitter ⚠
- p.Val511Met Single submitter ⚠
- p.Val530Met Single submitter ⚠