CARNS1 — 182 ClinVar variants
All ClinVar germline CARNS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 155 flagged for review →
1 Conflicting · 6 Likely benign · 175 Uncertain significance
Full CARNS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 155
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CARNS1 p.Ala145Val Uncertain significance Single submitter
- CARNS1 p.Ala190Thr Uncertain significance Single submitter
- CARNS1 p.Ala536Val Uncertain significance Single submitter
- CARNS1 p.Ala691Val Uncertain significance Single submitter
- CARNS1 p.Ala848Thr Uncertain significance Single submitter
- CARNS1 p.Ala848Val Uncertain significance Single submitter
- CARNS1 p.Ala922Val Uncertain significance Single submitter
- CARNS1 p.Arg185Gln Uncertain significance Single submitter
- CARNS1 p.Arg185Trp Uncertain significance Single submitter
- CARNS1 p.Arg208Gln Uncertain significance Single submitter
- CARNS1 p.Arg295Gln Uncertain significance Single submitter
- CARNS1 p.Arg354Gln Uncertain significance Single submitter
- CARNS1 p.Arg366Lys Uncertain significance Single submitter
- CARNS1 p.Arg381Leu Uncertain significance Single submitter
- CARNS1 p.Arg488Gln Uncertain significance Single submitter
- CARNS1 p.Arg507Leu Uncertain significance Single submitter
- CARNS1 p.Arg570Gln Uncertain significance Single submitter
- CARNS1 p.Arg700Trp Uncertain significance Single submitter
- CARNS1 p.Arg743Gln Uncertain significance Single submitter
- CARNS1 p.Arg816Cys Uncertain significance Single submitter
- CARNS1 p.Arg854His Uncertain significance Single submitter
- CARNS1 p.Arg856His Uncertain significance Single submitter
- CARNS1 p.Asn894Ser Uncertain significance Single submitter
- CARNS1 p.Asp710Asn Uncertain significance Single submitter
- CARNS1 p.Asp734Gly Uncertain significance Single submitter
- CARNS1 p.Cys652Arg Uncertain significance Single submitter
- CARNS1 p.Gln706Leu Uncertain significance Single submitter
- CARNS1 p.Gln868Arg Uncertain significance Single submitter
- CARNS1 p.Glu205Gly Uncertain significance Single submitter
- CARNS1 p.Glu277Gln Uncertain significance Single submitter
- CARNS1 p.Glu320Gln Uncertain significance Single submitter
- CARNS1 p.Glu481Asp Uncertain significance Single submitter
- CARNS1 p.Glu568Lys Uncertain significance Single submitter
- CARNS1 p.Gly348Ser Uncertain significance Single submitter
- CARNS1 p.Gly470Arg Uncertain significance Single submitter
- CARNS1 p.Gly523Arg Uncertain significance Single submitter
- CARNS1 p.Gly525Ser Uncertain significance Single submitter
- CARNS1 p.Gly707Ser Uncertain significance Single submitter
- CARNS1 p.Gly770Arg Uncertain significance Single submitter
- CARNS1 p.Gly818Arg Uncertain significance Single submitter
- CARNS1 p.Gly819Ser Uncertain significance Single submitter
- CARNS1 p.His637Tyr Uncertain significance Single submitter
- CARNS1 p.His886Gln Uncertain significance Single submitter
- CARNS1 p.Ile562Val Uncertain significance Single submitter
- CARNS1 p.Leu283Arg Uncertain significance Single submitter
- CARNS1 p.Leu519Arg Uncertain significance Single submitter
- CARNS1 p.Leu519Val Uncertain significance Single submitter
- CARNS1 p.Leu520Pro Uncertain significance Single submitter
- CARNS1 p.Leu541Ile Uncertain significance Single submitter
- CARNS1 p.Leu895Arg Uncertain significance Single submitter
- CARNS1 p.Lys151Gln Uncertain significance Single submitter
- CARNS1 p.Lys517Arg Uncertain significance Single submitter
- CARNS1 p.Met722Thr Uncertain significance Single submitter
- CARNS1 p.Phe561Val Uncertain significance Single submitter
- CARNS1 p.Pro345Leu Uncertain significance Single submitter
- CARNS1 p.Pro382Leu Uncertain significance Single submitter
- CARNS1 p.Ser616Gly Uncertain significance Single submitter
- CARNS1 p.Ser911Gly Uncertain significance Single submitter
- CARNS1 p.Thr755Met Uncertain significance Single submitter
- CARNS1 p.Trp484Gly Uncertain significance Single submitter
- CARNS1 p.Tyr174His Uncertain significance Single submitter
- CARNS1 p.Val153Leu Uncertain significance Single submitter
- CARNS1 p.Val411Leu Uncertain significance Single submitter
- CARNS1 p.Val527Ile Uncertain significance Single submitter
- CARNS1 p.Val665Met Uncertain significance Single submitter
- CARNS1 p.Val688Leu Uncertain significance Single submitter
- CARNS1 p.Val735Met Uncertain significance Single submitter
- CARNS1 p.Val738Ala Uncertain significance Single submitter
Predictors split 87
The independent predictors disagree with each other — read with care.
- CARNS1 p.Ala152Ser Uncertain significance Single submitter
- CARNS1 p.Ala409Val Uncertain significance Single submitter
- CARNS1 p.Ala410Val Likely benign Single submitter
- CARNS1 p.Ala510Val Uncertain significance Single submitter
- CARNS1 p.Ala619Asp Uncertain significance Single submitter
- CARNS1 p.Ala664Thr Uncertain significance Single submitter
- CARNS1 p.Ala777Thr Uncertain significance Single submitter
- CARNS1 p.Arg170Cys Uncertain significance Single submitter
- CARNS1 p.Arg171Cys Uncertain significance Single submitter
- CARNS1 p.Arg171His Uncertain significance Single submitter
- CARNS1 p.Arg213Gln Uncertain significance Single submitter
- CARNS1 p.Arg243Trp Uncertain significance Single submitter
- CARNS1 p.Arg252Gln Uncertain significance Single submitter
- CARNS1 p.Arg293Cys Uncertain significance Single submitter
- CARNS1 p.Arg297Trp Uncertain significance Single submitter
- CARNS1 p.Arg301Cys Uncertain significance Single submitter
- CARNS1 p.Arg301His Likely benign Single submitter
- CARNS1 p.Arg361Gln Uncertain significance Single submitter
- CARNS1 p.Arg381Cys Uncertain significance Single submitter
- CARNS1 p.Arg414Leu Uncertain significance Single submitter
- CARNS1 p.Arg577Trp Uncertain significance Single submitter
- CARNS1 p.Arg584Gln Uncertain significance Single submitter
- CARNS1 p.Arg584Trp Uncertain significance Single submitter
- CARNS1 p.Arg586Cys Uncertain significance Single submitter
- CARNS1 p.Arg622Cys Uncertain significance Single submitter
- CARNS1 p.Arg622His Uncertain significance Single submitter
- CARNS1 p.Arg686Trp Uncertain significance Single submitter
- CARNS1 p.Arg743Trp Uncertain significance Single submitter
- CARNS1 p.Arg823His Uncertain significance Single submitter
- CARNS1 p.Arg856Cys Uncertain significance Single submitter
- CARNS1 p.Arg888Cys Uncertain significance Single submitter
- CARNS1 p.Arg888His Uncertain significance Single submitter
- CARNS1 p.Arg923Cys Uncertain significance Single submitter
- CARNS1 p.Arg923His Uncertain significance Single submitter
- CARNS1 p.Arg925His Uncertain significance Single submitter
- CARNS1 p.Asp380Asn Uncertain significance Single submitter
- CARNS1 p.Asp538Asn Uncertain significance Single submitter
- CARNS1 p.Cys356Ser Uncertain significance Single submitter
- CARNS1 p.Cys400Tyr Uncertain significance Single submitter
- CARNS1 p.Gln631Glu Uncertain significance Single submitter
- CARNS1 p.Glu268Lys Uncertain significance Single submitter
- CARNS1 p.Glu323Lys Uncertain significance Single submitter
- CARNS1 p.Glu420Gln Uncertain significance Single submitter
- CARNS1 p.Glu495Lys Uncertain significance Single submitter
- CARNS1 p.Glu574Lys Uncertain significance Single submitter
- CARNS1 p.Glu907Lys Uncertain significance Single submitter
- CARNS1 p.Gly201Glu Uncertain significance Single submitter
- CARNS1 p.Gly280Ser Uncertain significance Single submitter
- CARNS1 p.Gly350Val Uncertain significance Single submitter
- CARNS1 p.Gly377Ser Uncertain significance Single submitter
- CARNS1 p.Gly379Arg Uncertain significance Single submitter
- CARNS1 p.Gly516Ala Uncertain significance Single submitter
- CARNS1 p.Gly540Ala Uncertain significance Single submitter
- CARNS1 p.Gly540Arg Uncertain significance Single submitter
- CARNS1 p.Gly587Ser Uncertain significance Single submitter
- CARNS1 p.Gly713Ala Uncertain significance Single submitter
- CARNS1 p.Gly903Asp Uncertain significance Single submitter
- CARNS1 p.Gly934Ser Uncertain significance Single submitter
- CARNS1 p.His569Tyr Uncertain significance Single submitter
- CARNS1 p.His633Gln Uncertain significance Single submitter
- CARNS1 p.His636Tyr Uncertain significance Single submitter
- CARNS1 p.Leu468Gln Uncertain significance Single submitter
- CARNS1 p.Leu506Phe Uncertain significance Single submitter
- CARNS1 p.Leu705Trp Uncertain significance Single submitter
- CARNS1 p.Leu924Ile Uncertain significance Single submitter
- CARNS1 p.Phe175Ile Uncertain significance Single submitter
- CARNS1 p.Phe531Ser Uncertain significance Single submitter
- CARNS1 p.Pro142Leu Uncertain significance Single submitter
- CARNS1 p.Pro238Leu Uncertain significance Single submitter
- CARNS1 p.Pro239Thr Uncertain significance Single submitter
- CARNS1 p.Pro304Leu Conflicting Single submitter
- CARNS1 p.Pro390Leu Uncertain significance Single submitter
- CARNS1 p.Pro550Ser Uncertain significance Single submitter
- CARNS1 p.Pro758Leu Uncertain significance Single submitter
- CARNS1 p.Pro850Ser Uncertain significance Single submitter
- CARNS1 p.Ser203Leu Uncertain significance Single submitter
- CARNS1 p.Ser878Asn Uncertain significance Single submitter
- CARNS1 p.Thr235Ile Uncertain significance Single submitter
- CARNS1 p.Tyr830His Uncertain significance Single submitter
- CARNS1 p.Val270Leu Uncertain significance Single submitter
- CARNS1 p.Val285Ile Uncertain significance Single submitter
- CARNS1 p.Val311Met Uncertain significance Single submitter
- CARNS1 p.Val395Met Uncertain significance Single submitter
- CARNS1 p.Val464Glu Uncertain significance Single submitter
- CARNS1 p.Val546Met Uncertain significance Single submitter
- CARNS1 p.Val685Ile Uncertain significance Single submitter
- CARNS1 p.Val841Met Uncertain significance Single submitter
All CARNS1 variants
Conflicting classifications of pathogenicity 1
- p.Pro304Leu Single submitter ⚠
Likely benign 6
- p.Ala410Val Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Asp494Glu Single submitter
- p.Gly86Ser Single submitter
- p.Ser7Leu Single submitter
- p.Val460Met Single submitter
Uncertain significance 175
- p.Ala145Val Single submitter ⚠
- p.Ala152Ser Single submitter ⚠
- p.Ala190Thr Single submitter ⚠
- p.Ala409Val Single submitter ⚠
- p.Ala510Val Single submitter ⚠
- p.Ala536Val Single submitter ⚠
- p.Ala57Val Single submitter
- p.Ala619Asp Single submitter ⚠
- p.Ala61Val Single submitter
- p.Ala664Thr Single submitter ⚠
- p.Ala691Val Single submitter ⚠
- p.Ala777Thr Single submitter ⚠
- p.Ala848Thr Single submitter ⚠
- p.Ala848Val Single submitter ⚠
- p.Ala922Val Single submitter ⚠
- p.Ala96Val Single submitter
- p.Arg170Cys Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg185Trp Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg243Trp Single submitter ⚠
- p.Arg252Gln Single submitter ⚠
- p.Arg293Cys Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg297Trp Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg361Gln Single submitter ⚠
- p.Arg366Lys Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg381Leu Single submitter ⚠
- p.Arg414Leu Single submitter ⚠
- p.Arg43Cys Single submitter
- p.Arg488Gln Single submitter ⚠
- p.Arg507Leu Single submitter ⚠
- p.Arg570Gln Single submitter ⚠
- p.Arg577Trp Single submitter ⚠
- p.Arg584Gln Single submitter ⚠
- p.Arg584Trp Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg60Gln Single submitter
- p.Arg60Trp Single submitter
- p.Arg622Cys Single submitter ⚠
- p.Arg622His Single submitter ⚠
- p.Arg686Trp Single submitter ⚠
- p.Arg700Trp Single submitter ⚠
- p.Arg743Gln Single submitter ⚠
- p.Arg743Trp Single submitter ⚠
- p.Arg816Cys Single submitter ⚠
- p.Arg823His Single submitter ⚠
- p.Arg854His Single submitter ⚠
- p.Arg856Cys Single submitter ⚠
- p.Arg856His Single submitter ⚠
- p.Arg85Leu Single submitter
- p.Arg888Cys Single submitter ⚠
- p.Arg888His Single submitter ⚠
- p.Arg90Cys Single submitter
- p.Arg923Cys Single submitter ⚠
- p.Arg923His Single submitter ⚠
- p.Arg925His Single submitter ⚠
- p.Asn894Ser Single submitter ⚠
- p.Asp380Asn Single submitter ⚠
- p.Asp538Asn Single submitter ⚠
- p.Asp710Asn Single submitter ⚠
- p.Asp734Gly Single submitter ⚠
- p.Cys13Gly Single submitter
- p.Cys356Ser Single submitter ⚠
- p.Cys400Tyr Single submitter ⚠
- p.Cys652Arg Single submitter ⚠
- p.Cys73Tyr Single submitter
- p.Gln631Glu Single submitter ⚠
- p.Gln706Leu Single submitter ⚠
- p.Gln76Arg Single submitter
- p.Gln83Arg Single submitter
- p.Gln868Arg Single submitter ⚠
- p.Glu205Gly Single submitter ⚠
- p.Glu268Lys Single submitter ⚠
- p.Glu277Gln Single submitter ⚠
- p.Glu320Gln Single submitter ⚠
- p.Glu323Lys Single submitter ⚠
- p.Glu420Gln Single submitter ⚠
- p.Glu481Asp Single submitter ⚠
- p.Glu495Lys Single submitter ⚠
- p.Glu55Asp Single submitter
- p.Glu568Lys Single submitter ⚠
- p.Glu574Lys Single submitter ⚠
- p.Glu58Asp Single submitter
- p.Glu81Gln Single submitter
- p.Glu907Lys Single submitter ⚠
- p.Gly201Glu Single submitter ⚠
- p.Gly24Asp Single submitter
- p.Gly280Ser Single submitter ⚠
- p.Gly28Arg Single submitter
- p.Gly348Ser Single submitter ⚠
- p.Gly350Val Single submitter ⚠
- p.Gly377Ser Single submitter ⚠
- p.Gly379Arg Single submitter ⚠
- p.Gly470Arg Single submitter ⚠
- p.Gly516Ala Single submitter ⚠
- p.Gly523Arg Single submitter ⚠
- p.Gly525Ser Single submitter ⚠
- p.Gly540Ala Single submitter ⚠
- p.Gly540Arg Single submitter ⚠
- p.Gly587Ser Single submitter ⚠
- p.Gly707Ser Single submitter ⚠
- p.Gly713Ala Single submitter ⚠
- p.Gly770Arg Single submitter ⚠
- p.Gly818Arg Single submitter ⚠
- p.Gly819Ser Single submitter ⚠
- p.Gly903Asp Single submitter ⚠
- p.Gly934Ser Single submitter ⚠
- p.His569Tyr Single submitter ⚠
- p.His633Gln Single submitter ⚠
- p.His636Tyr Single submitter ⚠
- p.His637Tyr Single submitter ⚠
- p.His886Gln Single submitter ⚠
- p.Ile562Val Single submitter ⚠
- p.Leu283Arg Single submitter ⚠
- p.Leu468Gln Single submitter ⚠
- p.Leu506Phe Single submitter ⚠
- p.Leu519Arg Single submitter ⚠
- p.Leu519Val Single submitter ⚠
- p.Leu520Pro Single submitter ⚠
- p.Leu541Ile Single submitter ⚠
- p.Leu705Trp Single submitter ⚠
- p.Leu895Arg Single submitter ⚠
- p.Leu924Ile Single submitter ⚠
- p.Lys151Gln Single submitter ⚠
- p.Lys517Arg Single submitter ⚠
- p.Met124Ile Single submitter
- p.Met722Thr Single submitter ⚠
- p.Phe175Ile Single submitter ⚠
- p.Phe531Ser Single submitter ⚠
- p.Phe561Val Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro238Leu Single submitter ⚠
- p.Pro239Thr Single submitter ⚠
- p.Pro33Leu Single submitter
- p.Pro345Leu Single submitter ⚠
- p.Pro382Leu Single submitter ⚠
- p.Pro390Leu Single submitter ⚠
- p.Pro550Ser Single submitter ⚠
- p.Pro758Leu Single submitter ⚠
- p.Pro850Ser Single submitter ⚠
- p.Ser105Phe Single submitter
- p.Ser203Leu Single submitter ⚠
- p.Ser3Phe Single submitter
- p.Ser53Tyr Single submitter
- p.Ser616Gly Single submitter ⚠
- p.Ser7Ala Single submitter
- p.Ser878Asn Single submitter ⚠
- p.Ser911Gly Single submitter ⚠
- p.Thr235Ile Single submitter ⚠
- p.Thr755Met Single submitter ⚠
- p.Trp484Gly Single submitter ⚠
- p.Tyr174His Single submitter ⚠
- p.Tyr830His Single submitter ⚠
- p.Val153Leu Single submitter ⚠
- p.Val270Leu Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val311Met Single submitter ⚠
- p.Val395Met Single submitter ⚠
- p.Val411Leu Single submitter ⚠
- p.Val464Glu Single submitter ⚠
- p.Val527Ile Single submitter ⚠
- p.Val546Met Single submitter ⚠
- p.Val665Met Single submitter ⚠
- p.Val685Ile Single submitter ⚠
- p.Val688Leu Single submitter ⚠
- p.Val735Met Single submitter ⚠
- p.Val738Ala Single submitter ⚠
- p.Val841Met Single submitter ⚠