CASP5 — 74 ClinVar variants
All ClinVar germline CASP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
10 Likely benign · 64 Uncertain significance
Full CASP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CASP5 p.Ala195Thr Uncertain significance Single submitter
- CASP5 p.Ala359Val Uncertain significance Single submitter
- CASP5 p.Arg120Gln Uncertain significance Single submitter
- CASP5 p.Arg221Ser Uncertain significance Single submitter
- CASP5 p.Arg298His Uncertain significance Single submitter
- CASP5 p.Arg326Thr Uncertain significance Single submitter
- CASP5 p.Arg373His Uncertain significance Single submitter
- CASP5 p.Asn200Ile Uncertain significance Single submitter
- CASP5 p.Asn85Ser Uncertain significance Single submitter
- CASP5 p.Asp62Val Uncertain significance Single submitter
- CASP5 p.Gln313Arg Uncertain significance Single submitter
- CASP5 p.Glu150Ala Uncertain significance Single submitter
- CASP5 p.Glu408Gly Uncertain significance Single submitter
- CASP5 p.Glu98Gly Uncertain significance Single submitter
- CASP5 p.Gly20Val Uncertain significance Single submitter
- CASP5 p.Gly227Asp Uncertain significance Single submitter
- CASP5 p.Gly275Arg Uncertain significance Single submitter
- CASP5 p.His64Pro Uncertain significance Single submitter
- CASP5 p.Ile140Phe Uncertain significance Single submitter
- CASP5 p.Ile162Val Uncertain significance Single submitter
- CASP5 p.Ile419Thr Uncertain significance Single submitter
- CASP5 p.Leu115Phe Uncertain significance Single submitter
- CASP5 p.Leu115Val Uncertain significance Single submitter
- CASP5 p.Leu223Phe Uncertain significance Single submitter
- CASP5 p.Lys234Asn Uncertain significance Single submitter
- CASP5 p.Met71Leu Uncertain significance Single submitter
- CASP5 p.Phe14Cys Uncertain significance Single submitter
- CASP5 p.Phe203Val Uncertain significance Single submitter
- CASP5 p.Phe261Ser Uncertain significance Single submitter
- CASP5 p.Pro153Ser Uncertain significance Single submitter
- CASP5 p.Ser257Phe Uncertain significance Single submitter
- CASP5 p.Ser56Leu Uncertain significance Single submitter
- CASP5 p.Thr94Ile Uncertain significance Single submitter
- CASP5 p.Val309Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CASP5 p.Arg11Cys Uncertain significance Single submitter
- CASP5 p.Arg11His Likely benign Single submitter
- CASP5 p.Arg123Cys Uncertain significance Single submitter
- CASP5 p.Arg168Cys Uncertain significance Single submitter
- CASP5 p.Arg191Cys Uncertain significance Single submitter
- CASP5 p.Arg191His Uncertain significance Single submitter
- CASP5 p.Arg193Cys Uncertain significance Single submitter
- CASP5 p.Arg421Gln Uncertain significance Single submitter
- CASP5 p.Asn235Ser Uncertain significance Single submitter
- CASP5 p.Asp204Val Uncertain significance Single submitter
- CASP5 p.Asp232Gly Uncertain significance Single submitter
- CASP5 p.Asp305Gly Uncertain significance Single submitter
- CASP5 p.Cys166Phe Uncertain significance Single submitter
- CASP5 p.Cys361Ser Uncertain significance Single submitter
- CASP5 p.Gln46Arg Uncertain significance Single submitter
- CASP5 p.Glu271Gly Uncertain significance Single submitter
- CASP5 p.Glu344Lys Uncertain significance Single submitter
- CASP5 p.Glu98Gln Uncertain significance Single submitter
- CASP5 p.His395Tyr Uncertain significance Single submitter
- CASP5 p.Leu119Ser Uncertain significance Single submitter
- CASP5 p.Leu146Phe Uncertain significance Single submitter
- CASP5 p.Leu172Pro Uncertain significance Single submitter
- CASP5 p.Leu93Met Uncertain significance Single submitter
- CASP5 p.Ser256Phe Uncertain significance Single submitter
- CASP5 p.Ser257Cys Uncertain significance Single submitter
- CASP5 p.Ser302Arg Uncertain significance Single submitter
- CASP5 p.Thr141Ile Uncertain significance Single submitter
- CASP5 p.Val124Met Uncertain significance Single submitter
- CASP5 p.Val30Met Uncertain significance Single submitter
- CASP5 p.Val39Met Likely benign Single submitter
- CASP5 p.Val83Ala Uncertain significance Single submitter
All CASP5 variants
Likely benign 10
- p.Arg11His Single submitter ⚠
- p.Arg123His Single submitter
- p.Asn63Lys Single submitter
- p.Asp91Asn Single submitter
- p.Glu382Gln Single submitter
- p.Lys102Asn Single submitter
- p.Lys187Glu Single submitter
- p.Thr381Met Single submitter
- p.Thr68Pro Single submitter
- p.Val39Met Single submitter ⚠
Uncertain significance 64
- p.Ala195Thr Single submitter ⚠
- p.Ala359Val Single submitter ⚠
- p.Arg11Cys Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Arg193Cys Single submitter ⚠
- p.Arg221Ser Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg326Thr Single submitter ⚠
- p.Arg373His Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Asn200Ile Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asp204Val Single submitter ⚠
- p.Asp232Gly Single submitter ⚠
- p.Asp305Gly Single submitter ⚠
- p.Asp62Val Single submitter ⚠
- p.Cys166Phe Single submitter ⚠
- p.Cys361Ser Single submitter ⚠
- p.Gln313Arg Single submitter ⚠
- p.Gln46Arg Single submitter ⚠
- p.Glu150Ala Single submitter ⚠
- p.Glu271Gly Single submitter ⚠
- p.Glu344Lys Single submitter ⚠
- p.Glu408Gly Single submitter ⚠
- p.Glu98Gln Single submitter ⚠
- p.Glu98Gly Single submitter ⚠
- p.Gly20Val Single submitter ⚠
- p.Gly227Asp Single submitter ⚠
- p.Gly275Arg Single submitter ⚠
- p.His395Tyr Single submitter ⚠
- p.His64Pro Single submitter ⚠
- p.Ile140Phe Single submitter ⚠
- p.Ile162Val Single submitter ⚠
- p.Ile419Thr Single submitter ⚠
- p.Leu115Phe Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu119Ser Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu172Pro Single submitter ⚠
- p.Leu223Phe Single submitter ⚠
- p.Leu93Met Single submitter ⚠
- p.Lys234Asn Single submitter ⚠
- p.Met71Leu Single submitter ⚠
- p.Phe14Cys Single submitter ⚠
- p.Phe203Val Single submitter ⚠
- p.Phe261Ser Single submitter ⚠
- p.Pro153Ser Single submitter ⚠
- p.Ser256Phe Single submitter ⚠
- p.Ser257Cys Single submitter ⚠
- p.Ser257Phe Single submitter ⚠
- p.Ser302Arg Single submitter ⚠
- p.Ser56Leu Single submitter ⚠
- p.Thr141Ile Single submitter ⚠
- p.Thr94Ile Single submitter ⚠
- p.Val124Met Single submitter ⚠
- p.Val309Ile Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val83Ala Single submitter ⚠
- p.Arg421Ter No assertion criteria