CAVIN3 — 61 ClinVar variants
All ClinVar germline CAVIN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Likely benign · 60 Uncertain significance
Full CAVIN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CAVIN3 p.Ala141Ser Uncertain significance Single submitter
- CAVIN3 p.Ala218Gly Uncertain significance Single submitter
- CAVIN3 p.Ala220Ser Uncertain significance Single submitter
- CAVIN3 p.Ala227Val Uncertain significance Single submitter
- CAVIN3 p.Ala249Ser Uncertain significance Single submitter
- CAVIN3 p.Ala66Thr Uncertain significance Single submitter
- CAVIN3 p.Ala94Thr Uncertain significance Single submitter
- CAVIN3 p.Ala95Val Uncertain significance Single submitter
- CAVIN3 p.Arg190Gln Uncertain significance Single submitter
- CAVIN3 p.Arg211Ser Uncertain significance Single submitter
- CAVIN3 p.Asn93Lys Uncertain significance Single submitter
- CAVIN3 p.Gln150Lys Uncertain significance Single submitter
- CAVIN3 p.Gln157Pro Uncertain significance Single submitter
- CAVIN3 p.Gln184Arg Uncertain significance Single submitter
- CAVIN3 p.Gln221Arg Uncertain significance Single submitter
- CAVIN3 p.Gln61His Uncertain significance Single submitter
- CAVIN3 p.Glu258Asp Uncertain significance Single submitter
- CAVIN3 p.Glu3Gln Uncertain significance Single submitter
- CAVIN3 p.Gly154Ser Uncertain significance Single submitter
- CAVIN3 p.Gly17Glu Uncertain significance Single submitter
- CAVIN3 p.Gly213Ala Uncertain significance Single submitter
- CAVIN3 p.Gly63Arg Uncertain significance Single submitter
- CAVIN3 p.Gly63Ser Uncertain significance Single submitter
- CAVIN3 p.Leu254Gln Uncertain significance Single submitter
- CAVIN3 p.Leu64Arg Uncertain significance Single submitter
- CAVIN3 p.Leu6Ser Uncertain significance Single submitter
- CAVIN3 p.Lys128Glu Uncertain significance Single submitter
- CAVIN3 p.Lys84Asn Uncertain significance Single submitter
- CAVIN3 p.Pro199Leu Uncertain significance Single submitter
- CAVIN3 p.Ser259Arg Uncertain significance Single submitter
- CAVIN3 p.Ser259Gly Uncertain significance Single submitter
- CAVIN3 p.Ser62Arg Uncertain significance Single submitter
- CAVIN3 p.Ser62Gly Uncertain significance Single submitter
- CAVIN3 p.Ser68Thr Uncertain significance Single submitter
- CAVIN3 p.Thr231Ala Uncertain significance Single submitter
- CAVIN3 p.Thr27Ile Uncertain significance Single submitter
- CAVIN3 p.Val162Gly Uncertain significance Single submitter
- CAVIN3 p.Val25Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CAVIN3 p.Ala99Gly Uncertain significance Single submitter
- CAVIN3 p.Arg190Gly Uncertain significance Single submitter
- CAVIN3 p.Arg59Cys Uncertain significance Single submitter
- CAVIN3 p.Arg59Leu Uncertain significance Single submitter
- CAVIN3 p.Gln61Arg Uncertain significance Single submitter
- CAVIN3 p.Glu252Lys Uncertain significance Single submitter
- CAVIN3 p.Gly18Asp Uncertain significance Single submitter
- CAVIN3 p.Gly9Trp Uncertain significance Single submitter
- CAVIN3 p.His113Asn Uncertain significance Single submitter
- CAVIN3 p.His113Gln Uncertain significance Single submitter
- CAVIN3 p.Leu122Pro Uncertain significance Single submitter
- CAVIN3 p.Pro134Ser Uncertain significance Single submitter
- CAVIN3 p.Pro147Gln Uncertain significance Single submitter
- CAVIN3 p.Pro15Ser Uncertain significance Single submitter
- CAVIN3 p.Pro209Leu Uncertain significance Single submitter
- CAVIN3 p.Pro210Leu Uncertain significance Single submitter
- CAVIN3 p.Pro226Ser Uncertain significance Single submitter
- CAVIN3 p.Ser165Arg Uncertain significance Single submitter
- CAVIN3 p.Thr231Met Likely benign Single submitter
- CAVIN3 p.Val106Met Uncertain significance Single submitter
- CAVIN3 p.Val207Phe Uncertain significance Single submitter
- CAVIN3 p.Val20Met Uncertain significance Single submitter
- CAVIN3 p.Val26Met Uncertain significance Single submitter
All CAVIN3 variants
Likely benign 1
- p.Thr231Met Single submitter ⚠
Uncertain significance 60
- p.Ala141Ser Single submitter ⚠
- p.Ala218Gly Single submitter ⚠
- p.Ala220Ser Single submitter ⚠
- p.Ala227Val Single submitter ⚠
- p.Ala249Ser Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Ala99Gly Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg190Gly Single submitter ⚠
- p.Arg211Ser Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg59Leu Single submitter ⚠
- p.Asn93Lys Single submitter ⚠
- p.Gln150Lys Single submitter ⚠
- p.Gln157Pro Single submitter ⚠
- p.Gln184Arg Single submitter ⚠
- p.Gln221Arg Single submitter ⚠
- p.Gln61Arg Single submitter ⚠
- p.Gln61His Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Glu258Asp Single submitter ⚠
- p.Glu3Gln Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly17Glu Single submitter ⚠
- p.Gly18Asp Single submitter ⚠
- p.Gly213Ala Single submitter ⚠
- p.Gly63Arg Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Gly9Trp Single submitter ⚠
- p.His113Asn Single submitter ⚠
- p.His113Gln Single submitter ⚠
- p.Leu122Pro Single submitter ⚠
- p.Leu254Gln Single submitter ⚠
- p.Leu64Arg Single submitter ⚠
- p.Leu6Ser Single submitter ⚠
- p.Lys128Glu Single submitter ⚠
- p.Lys84Asn Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro147Gln Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro209Leu Single submitter ⚠
- p.Pro210Leu Single submitter ⚠
- p.Pro226Ser Single submitter ⚠
- p.Ser165Arg Single submitter ⚠
- p.Ser259Arg Single submitter ⚠
- p.Ser259Gly Single submitter ⚠
- p.Ser62Arg Single submitter ⚠
- p.Ser62Gly Single submitter ⚠
- p.Ser68Thr Single submitter ⚠
- p.Thr231Ala Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val162Gly Single submitter ⚠
- p.Val207Phe Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val25Met Single submitter ⚠
- p.Val26Met Single submitter ⚠