CBLL2 — 52 ClinVar variants
All ClinVar germline CBLL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Conflicting · 4 Benign · 9 Likely benign · 38 Uncertain significance
Full CBLL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBLL2 p.Ala283Val Uncertain significance Single submitter
- CBLL2 p.Arg108Gly Uncertain significance Single submitter
- CBLL2 p.Arg341His Uncertain significance Single submitter
- CBLL2 p.Arg95Cys Uncertain significance Single submitter
- CBLL2 p.Arg95His Uncertain significance Single submitter
- CBLL2 p.Asn361Ser Uncertain significance Single submitter
- CBLL2 p.Asp175Tyr Uncertain significance Single submitter
- CBLL2 p.Asp51Tyr Uncertain significance Single submitter
- CBLL2 p.Cys60Tyr Uncertain significance Single submitter
- CBLL2 p.Gln244Arg Uncertain significance Single submitter
- CBLL2 p.Gln312Glu Uncertain significance Single submitter
- CBLL2 p.Gly250Asp Uncertain significance Single submitter
- CBLL2 p.His156Arg Uncertain significance Single submitter
- CBLL2 p.His205Arg Uncertain significance Single submitter
- CBLL2 p.His359Tyr Uncertain significance Single submitter
- CBLL2 p.His418Gln Uncertain significance Single submitter
- CBLL2 p.Ile167Val Uncertain significance Single submitter
- CBLL2 p.Ile243Thr Uncertain significance Single submitter
- CBLL2 p.Ile45Asn Uncertain significance Single submitter
- CBLL2 p.Leu215Arg Uncertain significance Single submitter
- CBLL2 p.Leu362Val Uncertain significance Single submitter
- CBLL2 p.Lys330Asn Uncertain significance Single submitter
- CBLL2 p.Met196Thr Uncertain significance Single submitter
- CBLL2 p.Met335Arg Uncertain significance Single submitter
- CBLL2 p.Pro159Leu Uncertain significance Single submitter
- CBLL2 p.Pro211Leu Uncertain significance Single submitter
- CBLL2 p.Pro213Gln Uncertain significance Single submitter
- CBLL2 p.Pro401Leu Uncertain significance Single submitter
- CBLL2 p.Ser149Leu Uncertain significance Single submitter
- CBLL2 p.Ser270Leu Uncertain significance Single submitter
- CBLL2 p.Val117Leu Uncertain significance Single submitter
- CBLL2 p.Val193Leu Uncertain significance Single submitter
- CBLL2 p.Val240Ala Uncertain significance Single submitter
- CBLL2 p.Val27Glu Uncertain significance Single submitter
- CBLL2 p.Val292Gly Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CBLL2 p.Arg137His Likely benign Single submitter
- CBLL2 p.Arg424Gln Uncertain significance Single submitter
- CBLL2 p.Pro94Leu Uncertain significance Single submitter
- CBLL2 p.Ser115Cys Uncertain significance Single submitter
- CBLL2 p.Ser324Pro Likely benign Single submitter
- CBLL2 p.Thr318Met Likely benign Single submitter
All CBLL2 variants
Conflicting classifications of pathogenicity 1
- p.Arg310His Single submitter ⚠
Benign 4
- p.Arg389= Multiple submitters
- p.Ile33Asn Multiple submitters
- p.Leu215= Multiple submitters
- p.Ile180Asn Single submitter
Likely benign 9
- p.Arg122Lys Single submitter
- p.Arg137His Single submitter ⚠
- p.Arg310Cys Single submitter
- p.Arg403Gln Single submitter
- p.Arg424Pro Single submitter
- p.Ile276Met Single submitter
- p.Ile54Val Single submitter
- p.Ser324Pro Single submitter ⚠
- p.Thr318Met Single submitter ⚠
Uncertain significance 38
- p.Ala283Val Single submitter ⚠
- p.Arg108Gly Single submitter ⚠
- p.Arg341His Single submitter ⚠
- p.Arg424Gln Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asp175Tyr Single submitter ⚠
- p.Asp51Tyr Single submitter ⚠
- p.Cys60Tyr Single submitter ⚠
- p.Gln244Arg Single submitter ⚠
- p.Gln312Glu Single submitter ⚠
- p.Gly250Asp Single submitter ⚠
- p.His156Arg Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.His359Tyr Single submitter ⚠
- p.His418Gln Single submitter ⚠
- p.Ile167Val Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile45Asn Single submitter ⚠
- p.Leu215Arg Single submitter ⚠
- p.Leu362Val Single submitter ⚠
- p.Lys330Asn Single submitter ⚠
- p.Met196Thr Single submitter ⚠
- p.Met335Arg Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Pro213Gln Single submitter ⚠
- p.Pro401Leu Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser115Cys Single submitter ⚠
- p.Ser149Leu Single submitter ⚠
- p.Ser270Leu Single submitter ⚠
- p.Val117Leu Single submitter ⚠
- p.Val193Leu Single submitter ⚠
- p.Val240Ala Single submitter ⚠
- p.Val27Glu Single submitter ⚠
- p.Val292Gly Single submitter ⚠