CBLN3 — 44 ClinVar variants
All ClinVar germline CBLN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
44 Uncertain significance
Full CBLN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBLN3 p.Ala76Glu Uncertain significance Single submitter
- CBLN3 p.Arg136Cys Uncertain significance Single submitter
- CBLN3 p.Arg178Gln Uncertain significance Single submitter
- CBLN3 p.Arg184His Uncertain significance Single submitter
- CBLN3 p.Arg71Pro Uncertain significance Single submitter
- CBLN3 p.Asn187Ser Uncertain significance Single submitter
- CBLN3 p.Asn90Ser Uncertain significance Single submitter
- CBLN3 p.Asp99Asn Uncertain significance Single submitter
- CBLN3 p.Glu105Ala Uncertain significance Single submitter
- CBLN3 p.Glu37Ala Uncertain significance Single submitter
- CBLN3 p.Glu44Ala Uncertain significance Single submitter
- CBLN3 p.Glu87Gly Uncertain significance Single submitter
- CBLN3 p.Gly106Ser Uncertain significance Single submitter
- CBLN3 p.Gly107Ser Uncertain significance Single submitter
- CBLN3 p.Gly122Ser Uncertain significance Single submitter
- CBLN3 p.Gly17Arg Uncertain significance Single submitter
- CBLN3 p.Gly3Arg Uncertain significance Single submitter
- CBLN3 p.Gly61Glu Uncertain significance Single submitter
- CBLN3 p.Leu201Phe Uncertain significance Single submitter
- CBLN3 p.Pro119Leu Uncertain significance Single submitter
- CBLN3 p.Pro12Arg Uncertain significance Single submitter
- CBLN3 p.Pro6Leu Uncertain significance Single submitter
- CBLN3 p.Thr161Ser Uncertain significance Single submitter
- CBLN3 p.Trp192Cys Uncertain significance Single submitter
- CBLN3 p.Val141Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CBLN3 p.Ala67Thr Uncertain significance Single submitter
- CBLN3 p.Ala76Val Uncertain significance Single submitter
- CBLN3 p.Arg111Trp Uncertain significance Single submitter
- CBLN3 p.Arg121Trp Uncertain significance Single submitter
- CBLN3 p.Arg185Gln Uncertain significance Single submitter
- CBLN3 p.Cys45Trp Uncertain significance Single submitter
- CBLN3 p.Glu105Lys Uncertain significance Single submitter
- CBLN3 p.Gly108Val Uncertain significance Single submitter
- CBLN3 p.Gly28Val Uncertain significance Single submitter
- CBLN3 p.Gly30Arg Uncertain significance Single submitter
- CBLN3 p.Gly57Glu Uncertain significance Single submitter
- CBLN3 p.Gly58Arg Uncertain significance Single submitter
- CBLN3 p.His7Tyr Uncertain significance Single submitter
- CBLN3 p.Leu205Val Uncertain significance Single submitter
- CBLN3 p.Leu24Ile Uncertain significance Single submitter
- CBLN3 p.Pro119Arg Uncertain significance Single submitter
- CBLN3 p.Pro158Ser Uncertain significance Single submitter
- CBLN3 p.Pro59Leu Uncertain significance Single submitter
- CBLN3 p.Val117Ile Uncertain significance Single submitter
All CBLN3 variants
Uncertain significance 44
- p.Ala67Thr Single submitter ⚠
- p.Ala76Glu Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg111Trp Single submitter ⚠
- p.Arg121Trp Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg71Pro Single submitter ⚠
- p.Asn187Ser Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp99Asn Single submitter ⚠
- p.Cys45Trp Single submitter ⚠
- p.Glu105Ala Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu37Ala Single submitter ⚠
- p.Glu44Ala Single submitter ⚠
- p.Glu87Gly Single submitter ⚠
- p.Gly106Ser Single submitter ⚠
- p.Gly107Ser Single submitter ⚠
- p.Gly108Val Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly28Val Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly3Arg Single submitter ⚠
- p.Gly57Glu Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.Gly61Glu Single submitter ⚠
- p.His7Tyr Single submitter ⚠
- p.Leu201Phe Single submitter ⚠
- p.Leu205Val Single submitter ⚠
- p.Leu24Ile Single submitter ⚠
- p.Pro119Arg Single submitter ⚠
- p.Pro119Leu Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro158Ser Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Thr161Ser Single submitter ⚠
- p.Trp192Cys Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val141Met Single submitter ⚠