CBR3 — 48 ClinVar variants
All ClinVar germline CBR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 1 Likely benign · 46 Uncertain significance
Full CBR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBR3 p.Ala41Thr Uncertain significance Single submitter
- CBR3 p.Arg211Cys Uncertain significance Single submitter
- CBR3 p.Asn181His Uncertain significance Single submitter
- CBR3 p.Asn90Lys Uncertain significance Single submitter
- CBR3 p.Asp63Gly Uncertain significance Single submitter
- CBR3 p.Asp75Glu Uncertain significance Single submitter
- CBR3 p.Cys122Ser Uncertain significance Single submitter
- CBR3 p.Cys150Arg Uncertain significance Single submitter
- CBR3 p.Cys26Tyr Uncertain significance Single submitter
- CBR3 p.Glu108Asp Uncertain significance Single submitter
- CBR3 p.Glu246Asp Uncertain significance Single submitter
- CBR3 p.Gly18Ser Uncertain significance Single submitter
- CBR3 p.Leu199Trp Uncertain significance Single submitter
- CBR3 p.Leu87Gln Uncertain significance Single submitter
- CBR3 p.Lys272Arg Uncertain significance Single submitter
- CBR3 p.Met121Thr Uncertain significance Single submitter
- CBR3 p.Pro193Ser Uncertain significance Single submitter
- CBR3 p.Ser2Leu Uncertain significance Single submitter
- CBR3 p.Ser2Trp Uncertain significance Single submitter
- CBR3 p.Thr118Ile Uncertain significance Single submitter
- CBR3 p.Thr233Ser Uncertain significance Single submitter
- CBR3 p.Thr262Ala Uncertain significance Single submitter
- CBR3 p.Thr36Pro Uncertain significance Single submitter
- CBR3 p.Trp189Arg Uncertain significance Single submitter
- CBR3 p.Val135Gly Uncertain significance Single submitter
- CBR3 p.Val183Met Uncertain significance Single submitter
- CBR3 p.Val40Met Uncertain significance Single submitter
- CBR3 p.Val86Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CBR3 p.Ala225Val Uncertain significance Single submitter
- CBR3 p.Gln51His Uncertain significance Single submitter
- CBR3 p.Glu124Gln Uncertain significance Single submitter
- CBR3 p.Glu124Lys Benign Single submitter
- CBR3 p.Gly54Asp Uncertain significance Single submitter
- CBR3 p.Ile17Phe Uncertain significance Single submitter
- CBR3 p.Ile17Thr Uncertain significance Single submitter
- CBR3 p.Leu222Gln Uncertain significance Single submitter
- CBR3 p.Lys198Thr Uncertain significance Single submitter
- CBR3 p.Met129Thr Uncertain significance Single submitter
- CBR3 p.Phe158Tyr Uncertain significance Single submitter
- CBR3 p.Pro127Leu Uncertain significance Single submitter
- CBR3 p.Ser205Trp Uncertain significance Single submitter
- CBR3 p.Thr118Pro Uncertain significance Single submitter
- CBR3 p.Thr202Lys Uncertain significance Single submitter
- CBR3 p.Val274Met Uncertain significance Single submitter
All CBR3 variants
Benign 1
- p.Glu124Lys Single submitter ⚠
Likely benign 1
- p.Arg211His Single submitter
Uncertain significance 46
- p.Ala225Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg211Cys Single submitter ⚠
- p.Asn181His Single submitter ⚠
- p.Asn90Lys Single submitter ⚠
- p.Asp63Ala Single submitter
- p.Asp63Gly Single submitter ⚠
- p.Asp75Glu Single submitter ⚠
- p.Cys122Ser Single submitter ⚠
- p.Cys150Arg Single submitter ⚠
- p.Cys26Tyr Single submitter ⚠
- p.Gln51His Single submitter ⚠
- p.Glu108Asp Single submitter ⚠
- p.Glu124Gln Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Gly18Ser Single submitter ⚠
- p.Gly229Arg Single submitter
- p.Gly54Asp Single submitter ⚠
- p.Ile17Phe Single submitter ⚠
- p.Ile17Thr Single submitter ⚠
- p.Leu199Trp Single submitter ⚠
- p.Leu222Gln Single submitter ⚠
- p.Leu87Gln Single submitter ⚠
- p.Lys198Thr Single submitter ⚠
- p.Lys272Arg Single submitter ⚠
- p.Met121Thr Single submitter ⚠
- p.Met129Thr Single submitter ⚠
- p.Phe158Tyr Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro57Ser Single submitter
- p.Ser205Trp Single submitter ⚠
- p.Ser2Leu Single submitter ⚠
- p.Ser2Trp Single submitter ⚠
- p.Thr118Ile Single submitter ⚠
- p.Thr118Pro Single submitter ⚠
- p.Thr202Lys Single submitter ⚠
- p.Thr233Ser Single submitter ⚠
- p.Thr262Ala Single submitter ⚠
- p.Thr36Pro Single submitter ⚠
- p.Trp189Arg Single submitter ⚠
- p.Val135Gly Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val274Met Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val86Ile Single submitter ⚠