CBR4 — 38 ClinVar variants
All ClinVar germline CBR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Benign · 2 Likely benign · 35 Uncertain significance
Full CBR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBR4 p.Ala42Thr Uncertain significance Single submitter
- CBR4 p.Ala43Val Uncertain significance Single submitter
- CBR4 p.Arg172Gly Uncertain significance Single submitter
- CBR4 p.Arg34Lys Uncertain significance Single submitter
- CBR4 p.Asp184His Uncertain significance Single submitter
- CBR4 p.Gly38Glu Uncertain significance Single submitter
- CBR4 p.His211Arg Uncertain significance Single submitter
- CBR4 p.Leu29Gln Uncertain significance Single submitter
- CBR4 p.Lys169Arg Uncertain significance Single submitter
- CBR4 p.Lys59Glu Uncertain significance Single submitter
- CBR4 p.Met112Thr Uncertain significance Single submitter
- CBR4 p.Met119Thr Uncertain significance Single submitter
- CBR4 p.Ser11Phe Uncertain significance Single submitter
- CBR4 p.Ser135Arg Uncertain significance Single submitter
- CBR4 p.Val229Glu Uncertain significance Single submitter
- CBR4 p.Val57Phe Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CBR4 p.Ala177Val Uncertain significance Single submitter
- CBR4 p.Ala17Gly Uncertain significance Single submitter
- CBR4 p.Ala19Val Uncertain significance Single submitter
- CBR4 p.Ala212Val Uncertain significance Single submitter
- CBR4 p.Arg120Ser Uncertain significance Single submitter
- CBR4 p.Arg160Cys Uncertain significance Single submitter
- CBR4 p.Arg16Thr Uncertain significance Single submitter
- CBR4 p.Cys55Gly Uncertain significance Single submitter
- CBR4 p.Gln124His Uncertain significance Single submitter
- CBR4 p.Glu60Lys Uncertain significance Single submitter
- CBR4 p.His50Asp Uncertain significance Single submitter
- CBR4 p.Ile130Val Uncertain significance Single submitter
- CBR4 p.Leu46Val Uncertain significance Single submitter
- CBR4 p.Met100Thr Uncertain significance Single submitter
- CBR4 p.Phe53Val Uncertain significance Single submitter
- CBR4 p.Pro220Leu Uncertain significance Single submitter
- CBR4 p.Ser129Thr Uncertain significance Single submitter
- CBR4 p.Ser54Cys Uncertain significance Single submitter
- CBR4 p.Thr66Ile Uncertain significance Single submitter
All CBR4 variants
Benign 1
- c.401-11_401-8del Single submitter
Likely benign 2
- p.Arg120Lys Single submitter
- p.Met119Val Single submitter
Uncertain significance 35
- p.Ala177Val Single submitter ⚠
- p.Ala17Gly Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala42Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Arg120Ser Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg16Thr Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg34Lys Single submitter ⚠
- p.Asp184His Single submitter ⚠
- p.Cys55Gly Single submitter ⚠
- p.Gln124His Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Gly38Glu Single submitter ⚠
- p.His211Arg Single submitter ⚠
- p.His50Asp Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Leu29Gln Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Lys169Arg Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Met100Thr Single submitter ⚠
- p.Met112Thr Single submitter ⚠
- p.Met119Thr Single submitter ⚠
- p.Phe53Val Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Ser11Phe Single submitter ⚠
- p.Ser129Thr Single submitter ⚠
- p.Ser135Arg Single submitter ⚠
- p.Ser54Cys Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Val229Glu Single submitter ⚠
- p.Val57Phe Single submitter ⚠