CBX3 — 9 ClinVar variants
All ClinVar germline CBX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
9 Uncertain significance
Full CBX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBX3 p.Ala25Thr Uncertain significance Single submitter
- CBX3 p.Arg38Gln Uncertain significance Single submitter
- CBX3 p.Arg38Leu Uncertain significance Single submitter
- CBX3 p.Asn4Ser Uncertain significance Single submitter
- CBX3 p.Gly88Ser Uncertain significance Single submitter
- CBX3 p.Thr7Ile Uncertain significance Single submitter
- CBX3 p.Val40Ala Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All CBX3 variants
Uncertain significance 9
- p.Ala25Thr Single submitter ⚠
- p.Arg38Gln Single submitter ⚠
- p.Arg38Leu Single submitter ⚠
- p.Asn4Ser Single submitter ⚠
- p.Gly88Ser Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Val22Ile Single submitter ⚠
- p.Val40Ala Single submitter ⚠
- c.330+3A>G No assertion criteria Recurrent spontaneous abortion