CBX4 — 80 ClinVar variants
All ClinVar germline CBX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Benign · 78 Uncertain significance
Full CBX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBX4 p.Ala138Val Uncertain significance Single submitter
- CBX4 p.Ala236Val Uncertain significance Single submitter
- CBX4 p.Ala314Pro Uncertain significance Single submitter
- CBX4 p.Ala316Ser Uncertain significance Single submitter
- CBX4 p.Ala316Thr Uncertain significance Single submitter
- CBX4 p.Ala323Glu Uncertain significance Single submitter
- CBX4 p.Ala354Ser Uncertain significance Single submitter
- CBX4 p.Ala430Val Uncertain significance Single submitter
- CBX4 p.Ala522Val Uncertain significance Single submitter
- CBX4 p.Arg20Leu Uncertain significance Single submitter
- CBX4 p.Arg290Gly Uncertain significance Single submitter
- CBX4 p.Arg421His Uncertain significance Single submitter
- CBX4 p.Arg70Gln Uncertain significance Single submitter
- CBX4 p.Asn231Ser Uncertain significance Single submitter
- CBX4 p.Asn91Ser Uncertain significance Single submitter
- CBX4 p.Asp102Glu Uncertain significance Single submitter
- CBX4 p.Asp342His Uncertain significance Single submitter
- CBX4 p.Asp524Asn Uncertain significance Single submitter
- CBX4 p.Gln174Arg Uncertain significance Single submitter
- CBX4 p.Gln174Glu Uncertain significance Single submitter
- CBX4 p.Gln341Arg Uncertain significance Single submitter
- CBX4 p.Glu483Ala Uncertain significance Single submitter
- CBX4 p.Gly113Arg Uncertain significance Single submitter
- CBX4 p.Gly24Ser Uncertain significance Single submitter
- CBX4 p.Gly282Arg Uncertain significance Single submitter
- CBX4 p.Gly287Arg Uncertain significance Single submitter
- CBX4 p.Gly334Arg Uncertain significance Single submitter
- CBX4 p.Gly485Arg Uncertain significance Single submitter
- CBX4 p.His133Tyr Uncertain significance Single submitter
- CBX4 p.His400Gln Uncertain significance Single submitter
- CBX4 p.Ile246Thr Uncertain significance Single submitter
- CBX4 p.Leu368Gln Uncertain significance Single submitter
- CBX4 p.Leu550Phe Uncertain significance Single submitter
- CBX4 p.Lys238Glu Uncertain significance Single submitter
- CBX4 p.Pro338Leu Uncertain significance Single submitter
- CBX4 p.Pro350Arg Uncertain significance Single submitter
- CBX4 p.Pro350Thr Uncertain significance Single submitter
- CBX4 p.Ser134Gly Uncertain significance Single submitter
- CBX4 p.Ser381Pro Uncertain significance Single submitter
- CBX4 p.Ser531Arg Uncertain significance Single submitter
- CBX4 p.Thr437Ile Uncertain significance Single submitter
- CBX4 p.Thr94Ser Uncertain significance Single submitter
- CBX4 p.Val402Ile Uncertain significance Single submitter
- CBX4 p.Val409Met Uncertain significance Single submitter
- CBX4 p.Val462Ile Uncertain significance Single submitter
- CBX4 p.Val493Ala Uncertain significance Single submitter
- CBX4 p.Val493Leu Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CBX4 p.Ala298Val Uncertain significance Single submitter
- CBX4 p.Ala499Val Uncertain significance Single submitter
- CBX4 p.Arg346Cys Uncertain significance Single submitter
- CBX4 p.Arg427Trp Uncertain significance Single submitter
- CBX4 p.Arg447Cys Uncertain significance Single submitter
- CBX4 p.Asp466Tyr Uncertain significance Single submitter
- CBX4 p.Glu416Gln Uncertain significance Single submitter
- CBX4 p.Gly248Asp Uncertain significance Single submitter
- CBX4 p.Gly334Trp Uncertain significance Single submitter
- CBX4 p.His160Gln Uncertain significance Single submitter
- CBX4 p.His389Asn Uncertain significance Single submitter
- CBX4 p.His390Pro Uncertain significance Single submitter
- CBX4 p.His391Pro Uncertain significance Single submitter
- CBX4 p.His395Asp Uncertain significance Single submitter
- CBX4 p.His397Gln Uncertain significance Single submitter
- CBX4 p.His9Gln Uncertain significance Single submitter
- CBX4 p.Ile463Phe Uncertain significance Single submitter
- CBX4 p.Lys212Asn Uncertain significance Single submitter
- CBX4 p.Lys38Glu Uncertain significance Single submitter
- CBX4 p.Phe537Leu Uncertain significance Single submitter
- CBX4 p.Pro213Thr Uncertain significance Single submitter
- CBX4 p.Pro384Gln Uncertain significance Single submitter
- CBX4 p.Pro448Leu Uncertain significance Single submitter
- CBX4 p.Pro452Leu Uncertain significance Single submitter
- CBX4 p.Pro453Ser Uncertain significance Single submitter
- CBX4 p.Pro458Leu Uncertain significance Single submitter
- CBX4 p.Pro460Leu Uncertain significance Single submitter
- CBX4 p.Ser225Cys Uncertain significance Single submitter
- CBX4 p.Thr559Met Uncertain significance Single submitter
- CBX4 p.Val335Ile Uncertain significance Single submitter
- CBX4 p.Val493Met Uncertain significance Single submitter
All CBX4 variants
Benign 2
- p.Arg70= Multiple submitters
- p.Ala509_Ala510dup Single submitter
Uncertain significance 78
- p.Ala138Val Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala298Val Single submitter ⚠
- p.Ala314Pro Single submitter ⚠
- p.Ala316Ser Single submitter ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala323Glu Single submitter ⚠
- p.Ala354Ser Single submitter ⚠
- p.Ala430Val Single submitter ⚠
- p.Ala499Val Single submitter ⚠
- p.Ala522Val Single submitter ⚠
- p.Arg20Leu Single submitter ⚠
- p.Arg290Gly Single submitter ⚠
- p.Arg346Cys Single submitter ⚠
- p.Arg421His Single submitter ⚠
- p.Arg427Trp Single submitter ⚠
- p.Arg447Cys Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Asn231Ser Single submitter ⚠
- p.Asn91Ser Single submitter ⚠
- p.Asp102Glu Single submitter ⚠
- p.Asp342His Single submitter ⚠
- p.Asp466Tyr Single submitter ⚠
- p.Asp524Asn Single submitter ⚠
- p.Gln174Arg Single submitter ⚠
- p.Gln174Glu Single submitter ⚠
- p.Gln341Arg Single submitter ⚠
- p.Glu416Gln Single submitter ⚠
- p.Glu483Ala Single submitter ⚠
- p.Gly113Arg Single submitter ⚠
- p.Gly248Asp Single submitter ⚠
- p.Gly24Ser Single submitter ⚠
- p.Gly282Arg Single submitter ⚠
- p.Gly287Arg Single submitter ⚠
- p.Gly334Arg Single submitter ⚠
- p.Gly334Trp Single submitter ⚠
- p.Gly485Arg Single submitter ⚠
- p.His133Tyr Single submitter ⚠
- p.His160Gln Single submitter ⚠
- p.His389Asn Single submitter ⚠
- p.His390Pro Single submitter ⚠
- p.His391Pro Single submitter ⚠
- p.His395Asp Single submitter ⚠
- p.His397Gln Single submitter ⚠
- p.His400Gln Single submitter ⚠
- p.His9Gln Single submitter ⚠
- p.Ile246Thr Single submitter ⚠
- p.Ile463Phe Single submitter ⚠
- p.Leu368Gln Single submitter ⚠
- p.Leu550Phe Single submitter ⚠
- p.Lys212Asn Single submitter ⚠
- p.Lys238Glu Single submitter ⚠
- p.Lys38Glu Single submitter ⚠
- p.Phe537Leu Single submitter ⚠
- p.Pro213Thr Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro350Arg Single submitter ⚠
- p.Pro350Thr Single submitter ⚠
- p.Pro384Gln Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Pro452Leu Single submitter ⚠
- p.Pro453Ser Single submitter ⚠
- p.Pro458Leu Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Ser134Gly Single submitter ⚠
- p.Ser225Cys Single submitter ⚠
- p.Ser381Pro Single submitter ⚠
- p.Ser531Arg Single submitter ⚠
- p.Thr437Ile Single submitter ⚠
- p.Thr559Met Single submitter ⚠
- p.Thr94Ser Single submitter ⚠
- p.Val335Ile Single submitter ⚠
- p.Val402Ile Single submitter ⚠
- p.Val409Met Single submitter ⚠
- p.Val462Ile Single submitter ⚠
- p.Val493Ala Single submitter ⚠
- p.Val493Leu Single submitter ⚠
- p.Val493Met Single submitter ⚠