CBX6 — 58 ClinVar variants
All ClinVar germline CBX6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 54 Uncertain significance
Full CBX6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBX6 p.Ala240Thr Uncertain significance Single submitter
- CBX6 p.Ala304Val Uncertain significance Single submitter
- CBX6 p.Arg171Gln Uncertain significance Single submitter
- CBX6 p.Arg205Gln Uncertain significance Single submitter
- CBX6 p.Arg20Pro Uncertain significance Single submitter
- CBX6 p.Asn367Ser Uncertain significance Single submitter
- CBX6 p.Asp289Glu Uncertain significance Single submitter
- CBX6 p.Gln140Leu Uncertain significance Single submitter
- CBX6 p.Glu251Lys Uncertain significance Single submitter
- CBX6 p.Glu309Val Uncertain significance Single submitter
- CBX6 p.Glu361Lys Uncertain significance Single submitter
- CBX6 p.Gly187Ser Uncertain significance Single submitter
- CBX6 p.Gly248Ser Uncertain significance Single submitter
- CBX6 p.Gly405Ser Uncertain significance Single submitter
- CBX6 p.His111Gln Uncertain significance Single submitter
- CBX6 p.Met362Leu Uncertain significance Single submitter
- CBX6 p.Pro101Ala Uncertain significance Single submitter
- CBX6 p.Pro133Ser Uncertain significance Single submitter
- CBX6 p.Pro200Ser Uncertain significance Single submitter
- CBX6 p.Pro283Arg Uncertain significance Single submitter
- CBX6 p.Pro283Ser Uncertain significance Single submitter
- CBX6 p.Pro292Ala Uncertain significance Single submitter
- CBX6 p.Pro330Leu Uncertain significance Single submitter
- CBX6 p.Pro341Thr Uncertain significance Single submitter
- CBX6 p.Pro353Ser Uncertain significance Single submitter
- CBX6 p.Ser253Thr Uncertain significance Single submitter
- CBX6 p.Ser285Pro Uncertain significance Single submitter
- CBX6 p.Ser301Arg Uncertain significance Single submitter
- CBX6 p.Thr222Ala Uncertain significance Single submitter
- CBX6 p.Tyr268Cys Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CBX6 p.Ala190Thr Likely benign Single submitter
- CBX6 p.Ala196Val Uncertain significance Single submitter
- CBX6 p.Ala304Asp Uncertain significance Single submitter
- CBX6 p.Ala339Val Uncertain significance Single submitter
- CBX6 p.Ala343Asp Uncertain significance Single submitter
- CBX6 p.Ala347Thr Uncertain significance Single submitter
- CBX6 p.Arg147His Uncertain significance Single submitter
- CBX6 p.Arg221Pro Uncertain significance Single submitter
- CBX6 p.Arg327Trp Uncertain significance Single submitter
- CBX6 p.Arg64Cys Uncertain significance Single submitter
- CBX6 p.Glu345Gln Uncertain significance Single submitter
- CBX6 p.Glu354Lys Uncertain significance Single submitter
- CBX6 p.Gly141Trp Uncertain significance Single submitter
- CBX6 p.Gly405Cys Uncertain significance Single submitter
- CBX6 p.Leu295His Uncertain significance Single submitter
- CBX6 p.Met129Leu Uncertain significance Single submitter
- CBX6 p.Met227Arg Uncertain significance Single submitter
- CBX6 p.Met227Ile Uncertain significance Single submitter
- CBX6 p.Pro203Arg Uncertain significance Single submitter
- CBX6 p.Pro245Gln Uncertain significance Single submitter
- CBX6 p.Ser104Cys Uncertain significance Single submitter
- CBX6 p.Ser246Tyr Uncertain significance Single submitter
- CBX6 p.Ser280Leu Uncertain significance Single submitter
- CBX6 p.Ser303Cys Uncertain significance Single submitter
- CBX6 p.Ser375Thr Uncertain significance Single submitter
All CBX6 variants
Benign/Likely benign 1
- p.Arg72= Multiple submitters
Likely benign 3
- p.Ala190Thr Single submitter ⚠
- p.Ala266Thr Single submitter
- p.Pro139= Single submitter
Uncertain significance 54
- p.Ala196Val Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala304Asp Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala339Val Single submitter ⚠
- p.Ala343Asp Single submitter ⚠
- p.Ala347Thr Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg171Gln Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg20Pro Single submitter ⚠
- p.Arg221Pro Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg64Cys Single submitter ⚠
- p.Asn367Ser Single submitter ⚠
- p.Asp289Glu Single submitter ⚠
- p.Gln140Leu Single submitter ⚠
- p.Glu251Lys Single submitter ⚠
- p.Glu309Val Single submitter ⚠
- p.Glu345Gln Single submitter ⚠
- p.Glu354Lys Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Gly141Trp Single submitter ⚠
- p.Gly187Ser Single submitter ⚠
- p.Gly248Ser Single submitter ⚠
- p.Gly405Cys Single submitter ⚠
- p.Gly405Ser Single submitter ⚠
- p.His111Gln Single submitter ⚠
- p.Leu295His Single submitter ⚠
- p.Met129Leu Single submitter ⚠
- p.Met227Arg Single submitter ⚠
- p.Met227Ile Single submitter ⚠
- p.Met362Leu Single submitter ⚠
- p.Pro101Ala Single submitter ⚠
- p.Pro133Ser Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro203Arg Single submitter ⚠
- p.Pro245Gln Single submitter ⚠
- p.Pro283Arg Single submitter ⚠
- p.Pro283Ser Single submitter ⚠
- p.Pro292Ala Single submitter ⚠
- p.Pro330Leu Single submitter ⚠
- p.Pro341Thr Single submitter ⚠
- p.Pro353Ser Single submitter ⚠
- p.Ser104Cys Single submitter ⚠
- p.Ser246Tyr Single submitter ⚠
- p.Ser253Thr Single submitter ⚠
- p.Ser280Leu Single submitter ⚠
- p.Ser285Pro Single submitter ⚠
- p.Ser301Arg Single submitter ⚠
- p.Ser303Cys Single submitter ⚠
- p.Ser375Thr Single submitter ⚠
- p.Thr222Ala Single submitter ⚠
- p.Tyr268Cys Single submitter ⚠