CBX7 — 33 ClinVar variants
All ClinVar germline CBX7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Likely benign · 30 Uncertain significance
Full CBX7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBX7 p.Ala179Ser Uncertain significance Single submitter
- CBX7 p.Ala185Val Uncertain significance Single submitter
- CBX7 p.Ala202Val Uncertain significance Single submitter
- CBX7 p.Ala214Pro Uncertain significance Single submitter
- CBX7 p.Ala214Val Uncertain significance Single submitter
- CBX7 p.Arg170Gln Uncertain significance Single submitter
- CBX7 p.Arg90Gln Uncertain significance Single submitter
- CBX7 p.Asp203Glu Uncertain significance Single submitter
- CBX7 p.Glu190Asp Uncertain significance Single submitter
- CBX7 p.Gly110Asp Uncertain significance Single submitter
- CBX7 p.Leu204Pro Uncertain significance Single submitter
- CBX7 p.Lys119Glu Uncertain significance Single submitter
- CBX7 p.Pro157Leu Uncertain significance Single submitter
- CBX7 p.Pro195Ala Uncertain significance Single submitter
- CBX7 p.Ser152Leu Uncertain significance Single submitter
- CBX7 p.Tyr85Cys Uncertain significance Single submitter
- CBX7 p.Val182Ala Uncertain significance Single submitter
- CBX7 p.Val182Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CBX7 p.Arg140Cys Uncertain significance Single submitter
- CBX7 p.Arg159Cys Uncertain significance Single submitter
- CBX7 p.Arg235Cys Uncertain significance Single submitter
- CBX7 p.Arg245Gln Uncertain significance Single submitter
- CBX7 p.Arg70Gly Uncertain significance Single submitter
- CBX7 p.Arg78Gln Uncertain significance Single submitter
- CBX7 p.Glu188Lys Uncertain significance Single submitter
- CBX7 p.Glu199Lys Uncertain significance Single submitter
- CBX7 p.Glu206Lys Uncertain significance Single submitter
- CBX7 p.Pro213Ser Uncertain significance Single submitter
- CBX7 p.Val232Ile Uncertain significance Single submitter
-
CBX7 p.Pro76Arg
Uncertain significance
No assertion criteria
prostate cancer
All CBX7 variants
Likely benign 3
- p.Ala214Thr Single submitter
- p.Gly110= Single submitter
- p.Ile230Val Single submitter
Uncertain significance 30
- p.Ala179Ser Single submitter ⚠
- p.Ala185Val Single submitter ⚠
- p.Ala202Val Single submitter ⚠
- p.Ala214Pro Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg245Gln Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Asp203Glu Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Glu190Asp Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu206Lys Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Leu204Pro Single submitter ⚠
- p.Lys119Glu Single submitter ⚠
- p.Pro157Leu Single submitter ⚠
- p.Pro195Ala Single submitter ⚠
- p.Pro213Ser Single submitter ⚠
- p.Ser152Leu Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Val182Ala Single submitter ⚠
- p.Val182Ile Single submitter ⚠
- p.Val232Ile Single submitter ⚠
- p.Pro76Arg No assertion criteria prostate cancer ⚠