CBX8 — 49 ClinVar variants
All ClinVar germline CBX8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Likely benign · 48 Uncertain significance
Full CBX8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CBX8 p.Ala133Val Uncertain significance Single submitter
- CBX8 p.Ala251Thr Uncertain significance Single submitter
- CBX8 p.Ala276Thr Uncertain significance Single submitter
- CBX8 p.Ala55Glu Uncertain significance Single submitter
- CBX8 p.Ala55Val Uncertain significance Single submitter
- CBX8 p.Arg109Pro Uncertain significance Single submitter
- CBX8 p.Arg213Lys Uncertain significance Single submitter
- CBX8 p.Arg252Gly Uncertain significance Single submitter
- CBX8 p.Asn379Ser Uncertain significance Single submitter
- CBX8 p.Asp255Glu Uncertain significance Single submitter
- CBX8 p.Gln260Arg Uncertain significance Single submitter
- CBX8 p.Gly221Ser Uncertain significance Single submitter
- CBX8 p.Gly237Arg Uncertain significance Single submitter
-
CBX8 p.Gly7Glu
Uncertain significance
Single submitter
spastic cerebral palsy
- CBX8 p.Met26Val Uncertain significance Single submitter
- CBX8 p.Pro147Leu Uncertain significance Single submitter
- CBX8 p.Pro218His Uncertain significance Single submitter
- CBX8 p.Ser183Gly Uncertain significance Single submitter
- CBX8 p.Thr272Met Uncertain significance Single submitter
- CBX8 p.Val284Gly Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CBX8 p.Ala51Thr Uncertain significance Single submitter
- CBX8 p.Ala83Val Uncertain significance Single submitter
- CBX8 p.Arg148Gly Uncertain significance Single submitter
- CBX8 p.Arg148Pro Uncertain significance Single submitter
- CBX8 p.Arg150Gln Uncertain significance Single submitter
- CBX8 p.Arg150Leu Uncertain significance Single submitter
- CBX8 p.Arg150Trp Uncertain significance Single submitter
- CBX8 p.Arg158Gln Uncertain significance Single submitter
- CBX8 p.Arg158Trp Uncertain significance Single submitter
- CBX8 p.Arg162Gln Uncertain significance Single submitter
- CBX8 p.Arg172Gly Uncertain significance Single submitter
- CBX8 p.Arg174Gly Uncertain significance Single submitter
- CBX8 p.Arg174Leu Uncertain significance Single submitter
- CBX8 p.Arg178Gln Uncertain significance Single submitter
- CBX8 p.Arg199Gln Uncertain significance Single submitter
- CBX8 p.Arg204Trp Uncertain significance Single submitter
- CBX8 p.Arg306Trp Uncertain significance Single submitter
- CBX8 p.Asp155Asn Uncertain significance Single submitter
- CBX8 p.Gln249His Uncertain significance Single submitter
- CBX8 p.Glu177Val Uncertain significance Single submitter
- CBX8 p.Gly237Trp Uncertain significance Single submitter
- CBX8 p.Gly328Arg Uncertain significance Single submitter
- CBX8 p.Ile102Thr Uncertain significance Single submitter
- CBX8 p.Leu129Phe Uncertain significance Single submitter
- CBX8 p.Leu371Phe Uncertain significance Single submitter
- CBX8 p.Met26Ile Uncertain significance Single submitter
- CBX8 p.Pro266His Uncertain significance Single submitter
- CBX8 p.Ser352Asn Uncertain significance Single submitter
All CBX8 variants
Likely benign 1
- p.Arg143= Single submitter
Uncertain significance 48
- p.Ala133Val Single submitter ⚠
- p.Ala251Thr Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala55Glu Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Ala83Val Single submitter ⚠
- p.Arg109Pro Single submitter ⚠
- p.Arg148Gly Single submitter ⚠
- p.Arg148Pro Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg150Leu Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg158Trp Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg174Gly Single submitter ⚠
- p.Arg174Leu Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg204Trp Single submitter ⚠
- p.Arg213Lys Single submitter ⚠
- p.Arg252Gly Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Asn379Ser Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp255Glu Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Gln260Arg Single submitter ⚠
- p.Glu177Val Single submitter ⚠
- p.Gly221Ser Single submitter ⚠
- p.Gly237Arg Single submitter ⚠
- p.Gly237Trp Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly7Glu Single submitter spastic cerebral palsy ⚠
- p.Ile102Thr Single submitter ⚠
- p.Leu129Phe Single submitter ⚠
- p.Leu371Phe Single submitter ⚠
- p.Met26Ile Single submitter ⚠
- p.Met26Val Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro218His Single submitter ⚠
- p.Pro266His Single submitter ⚠
- p.Ser183Gly Single submitter ⚠
- p.Ser352Asn Single submitter ⚠
- p.Thr272Met Single submitter ⚠
- p.Val284Gly Single submitter ⚠