CCAR1 — 84 ClinVar variants
All ClinVar germline CCAR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
1 Likely benign · 83 Uncertain significance
Full CCAR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCAR1 p.Ala2Val Uncertain significance Single submitter
- CCAR1 p.Ala499Asp Uncertain significance Single submitter
- CCAR1 p.Ala878Ser Uncertain significance Single submitter
- CCAR1 p.Arg357Leu Uncertain significance Single submitter
- CCAR1 p.Arg384Cys Uncertain significance Single submitter
- CCAR1 p.Arg384His Uncertain significance Single submitter
- CCAR1 p.Arg475Gln Uncertain significance Single submitter
- CCAR1 p.Arg526Cys Uncertain significance Single submitter
- CCAR1 p.Arg717Gln Uncertain significance Single submitter
- CCAR1 p.Asn1133Ser Uncertain significance Single submitter
- CCAR1 p.Asn866Thr Uncertain significance Single submitter
- CCAR1 p.Asp700Asn Uncertain significance Single submitter
- CCAR1 p.Asp898Gly Uncertain significance Single submitter
- CCAR1 p.Asp985Ala Uncertain significance Single submitter
- CCAR1 p.Gln1141Lys Uncertain significance Single submitter
- CCAR1 p.Glu1019Lys Uncertain significance Single submitter
- CCAR1 p.Glu1045Lys Uncertain significance Single submitter
- CCAR1 p.Ile230Val Uncertain significance Single submitter
- CCAR1 p.Ile257Val Uncertain significance Single submitter
- CCAR1 p.Ile41Val Uncertain significance Single submitter
- CCAR1 p.Ile435Leu Uncertain significance Single submitter
- CCAR1 p.Ile435Val Uncertain significance Single submitter
- CCAR1 p.Ile712Val Uncertain significance Single submitter
- CCAR1 p.Ile786Val Uncertain significance Single submitter
- CCAR1 p.Ile899Thr Uncertain significance Single submitter
- CCAR1 p.Ile921Asn Uncertain significance Single submitter
- CCAR1 p.Leu940Phe Uncertain significance Single submitter
- CCAR1 p.Lys680Glu Uncertain significance Single submitter
- CCAR1 p.Lys963Arg Uncertain significance Single submitter
- CCAR1 p.Met1031Val Uncertain significance Single submitter
- CCAR1 p.Met1122Leu Uncertain significance Single submitter
- CCAR1 p.Met378Thr Uncertain significance Single submitter
- CCAR1 p.Met873Val Uncertain significance Single submitter
- CCAR1 p.Pro135Ala Uncertain significance Single submitter
- CCAR1 p.Pro223Ala Uncertain significance Single submitter
- CCAR1 p.Pro289Ser Uncertain significance Single submitter
- CCAR1 p.Pro312Leu Uncertain significance Single submitter
- CCAR1 p.Pro374Leu Uncertain significance Single submitter
- CCAR1 p.Ser137Ala Uncertain significance Single submitter
- CCAR1 p.Ser537Asn Uncertain significance Single submitter
- CCAR1 p.Ser685Pro Uncertain significance Single submitter
- CCAR1 p.Thr160Ser Uncertain significance Single submitter
- CCAR1 p.Trp577Cys Uncertain significance Single submitter
- CCAR1 p.Val1051Leu Uncertain significance Single submitter
- CCAR1 p.Val969Ala Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CCAR1 p.Arg300Gln Uncertain significance Single submitter
- CCAR1 p.Arg307Thr Uncertain significance Single submitter
- CCAR1 p.Arg327His Uncertain significance Single submitter
- CCAR1 p.Arg340Leu Uncertain significance Single submitter
- CCAR1 p.Arg345Gln Uncertain significance Single submitter
- CCAR1 p.Arg348Gln Uncertain significance Single submitter
- CCAR1 p.Arg350Gln Uncertain significance Single submitter
- CCAR1 p.Arg353Trp Uncertain significance Single submitter
- CCAR1 p.Arg361His Uncertain significance Single submitter
- CCAR1 p.Arg605His Uncertain significance Single submitter
- CCAR1 p.Arg714Cys Uncertain significance Single submitter
- CCAR1 p.Arg714His Uncertain significance Single submitter
- CCAR1 p.Arg811Gly Uncertain significance Single submitter
- CCAR1 p.Arg829Gln Uncertain significance Single submitter
- CCAR1 p.Arg897Ser Uncertain significance Single submitter
- CCAR1 p.Arg971His Uncertain significance Single submitter
- CCAR1 p.Asp841Asn Uncertain significance Single submitter
- CCAR1 p.Asp868Asn Uncertain significance Single submitter
- CCAR1 p.Gln251His Uncertain significance Single submitter
- CCAR1 p.Glu704Lys Uncertain significance Single submitter
- CCAR1 p.Glu874Gly Uncertain significance Single submitter
- CCAR1 p.Glu877Ala Uncertain significance Single submitter
- CCAR1 p.Gly1035Arg Uncertain significance Single submitter
- CCAR1 p.Gly308Glu Uncertain significance Single submitter
- CCAR1 p.Ile1069Val Uncertain significance Single submitter
- CCAR1 p.Ile525Met Uncertain significance Single submitter
- CCAR1 p.Ile712Thr Uncertain significance Single submitter
- CCAR1 p.Leu949Phe Uncertain significance Single submitter
- CCAR1 p.Lys606Asn Uncertain significance Single submitter
- CCAR1 p.Pro223Arg Uncertain significance Single submitter
- CCAR1 p.Pro727Leu Uncertain significance Single submitter
- CCAR1 p.Pro827Leu Uncertain significance Single submitter
- CCAR1 p.Ser375Ile Uncertain significance Single submitter
- CCAR1 p.Ser446Asn Uncertain significance Single submitter
- CCAR1 p.Ser454Thr Uncertain significance Single submitter
- CCAR1 p.Ser537Cys Uncertain significance Single submitter
- CCAR1 p.Val153Met Uncertain significance Single submitter
- CCAR1 p.Val961Ile Uncertain significance Single submitter
All CCAR1 variants
Likely benign 1
- p.Asp692Glu Single submitter
Uncertain significance 83
- p.Ala2Val Single submitter ⚠
- p.Ala499Asp Single submitter ⚠
- p.Ala878Ser Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg307Thr Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg340Leu Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg350Gln Single submitter ⚠
- p.Arg353Trp Single submitter ⚠
- p.Arg357Leu Single submitter ⚠
- p.Arg361His Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg475Gln Single submitter ⚠
- p.Arg526Cys Single submitter ⚠
- p.Arg605His Single submitter ⚠
- p.Arg714Cys Single submitter ⚠
- p.Arg714His Single submitter ⚠
- p.Arg717Gln Single submitter ⚠
- p.Arg811Gly Single submitter ⚠
- p.Arg829Gln Single submitter ⚠
- p.Arg897Ser Single submitter ⚠
- p.Arg971His Single submitter ⚠
- p.Asn1133Ser Single submitter ⚠
- p.Asn866Thr Single submitter ⚠
- p.Asp700Asn Single submitter ⚠
- p.Asp841Asn Single submitter ⚠
- p.Asp868Asn Single submitter ⚠
- p.Asp898Gly Single submitter ⚠
- p.Asp985Ala Single submitter ⚠
- p.Gln1141Lys Single submitter ⚠
- p.Gln251His Single submitter ⚠
- p.Glu1019Lys Single submitter ⚠
- p.Glu1045Lys Single submitter ⚠
- p.Glu704Lys Single submitter ⚠
- p.Glu874Gly Single submitter ⚠
- p.Glu877Ala Single submitter ⚠
- p.Gly1035Arg Single submitter ⚠
- p.Gly308Glu Single submitter ⚠
- p.Ile1069Val Single submitter ⚠
- p.Ile230Val Single submitter ⚠
- p.Ile257Val Single submitter ⚠
- p.Ile41Val Single submitter ⚠
- p.Ile435Leu Single submitter ⚠
- p.Ile435Val Single submitter ⚠
- p.Ile525Met Single submitter ⚠
- p.Ile712Thr Single submitter ⚠
- p.Ile712Val Single submitter ⚠
- p.Ile786Val Single submitter ⚠
- p.Ile899Thr Single submitter ⚠
- p.Ile921Asn Single submitter ⚠
- p.Leu940Phe Single submitter ⚠
- p.Leu949Phe Single submitter ⚠
- p.Lys606Asn Single submitter ⚠
- p.Lys680Glu Single submitter ⚠
- p.Lys963Arg Single submitter ⚠
- p.Met1031Val Single submitter ⚠
- p.Met1122Leu Single submitter ⚠
- p.Met378Thr Single submitter ⚠
- p.Met873Val Single submitter ⚠
- p.Pro135Ala Single submitter ⚠
- p.Pro223Ala Single submitter ⚠
- p.Pro223Arg Single submitter ⚠
- p.Pro289Ser Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Pro374Leu Single submitter ⚠
- p.Pro727Leu Single submitter ⚠
- p.Pro827Leu Single submitter ⚠
- p.Ser137Ala Single submitter ⚠
- p.Ser375Ile Single submitter ⚠
- p.Ser446Asn Single submitter ⚠
- p.Ser454Thr Single submitter ⚠
- p.Ser537Asn Single submitter ⚠
- p.Ser537Cys Single submitter ⚠
- p.Ser685Pro Single submitter ⚠
- p.Thr160Ser Single submitter ⚠
- p.Trp577Cys Single submitter ⚠
- p.Val1051Leu Single submitter ⚠
- p.Val153Met Single submitter ⚠
- p.Val961Ile Single submitter ⚠
- p.Val969Ala Single submitter ⚠