CCDC102B — 93 ClinVar variants
All ClinVar germline CCDC102B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
5 Benign · 7 Likely benign · 81 Uncertain significance
Full CCDC102B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC102B p.Ala100Val Uncertain significance Single submitter
- CCDC102B p.Ala149Val Uncertain significance Single submitter
- CCDC102B p.Ala53Val Uncertain significance Single submitter
- CCDC102B p.Ala59Val Uncertain significance Single submitter
- CCDC102B p.Ala86Ser Uncertain significance Single submitter
- CCDC102B p.Arg371Gly Uncertain significance Single submitter
- CCDC102B p.Arg399Ile Uncertain significance Single submitter
- CCDC102B p.Arg464Leu Uncertain significance Single submitter
- CCDC102B p.Arg8Gln Uncertain significance Single submitter
- CCDC102B p.Arg8Leu Uncertain significance Single submitter
- CCDC102B p.Asn2Ser Uncertain significance Single submitter
- CCDC102B p.Asn420His Uncertain significance Single submitter
- CCDC102B p.Asn440Ser Uncertain significance Single submitter
- CCDC102B p.Asp265Gly Uncertain significance Single submitter
- CCDC102B p.Asp28Asn Uncertain significance Single submitter
- CCDC102B p.Asp38Gly Uncertain significance Single submitter
- CCDC102B p.Asp38Val Uncertain significance Single submitter
- CCDC102B p.Asp481Gly Uncertain significance Single submitter
- CCDC102B p.Cys40Arg Uncertain significance Single submitter
- CCDC102B p.Cys70Arg Uncertain significance Single submitter
- CCDC102B p.Glu166Lys Uncertain significance Single submitter
- CCDC102B p.Glu186Asp Uncertain significance Single submitter
- CCDC102B p.Glu216Ala Uncertain significance Single submitter
- CCDC102B p.Glu282Val Uncertain significance Single submitter
- CCDC102B p.Glu289Lys Uncertain significance Single submitter
- CCDC102B p.Glu301Gln Uncertain significance Single submitter
- CCDC102B p.Glu326Gly Uncertain significance Single submitter
- CCDC102B p.Glu333Val Uncertain significance Single submitter
- CCDC102B p.Glu467Lys Uncertain significance Single submitter
- CCDC102B p.Glu504Lys Uncertain significance Single submitter
- CCDC102B p.Gly162Val Uncertain significance Single submitter
- CCDC102B p.Gly233Arg Uncertain significance Single submitter
- CCDC102B p.Gly235Ser Uncertain significance Single submitter
- CCDC102B p.His181Arg Uncertain significance Single submitter
- CCDC102B p.Ile15Leu Uncertain significance Single submitter
- CCDC102B p.Ile184Val Uncertain significance Single submitter
- CCDC102B p.Ile315Val Uncertain significance Single submitter
- CCDC102B p.Ile368Thr Uncertain significance Single submitter
- CCDC102B p.Ile368Val Uncertain significance Single submitter
- CCDC102B p.Ile414Val Uncertain significance Single submitter
- CCDC102B p.Leu260Ser Uncertain significance Single submitter
- CCDC102B p.Leu281Phe Uncertain significance Single submitter
- CCDC102B p.Leu73Ile Uncertain significance Single submitter
- CCDC102B p.Lys244Glu Uncertain significance Single submitter
- CCDC102B p.Lys373Asn Uncertain significance Single submitter
- CCDC102B p.Lys388Thr Uncertain significance Single submitter
- CCDC102B p.Lys475Asn Uncertain significance Single submitter
- CCDC102B p.Met217Ile Uncertain significance Single submitter
- CCDC102B p.Met92Ile Uncertain significance Single submitter
- CCDC102B p.Met92Val Uncertain significance Single submitter
- CCDC102B p.Pro219Thr Uncertain significance Single submitter
- CCDC102B p.Pro249Ser Uncertain significance Single submitter
- CCDC102B p.Ser142Asn Uncertain significance Single submitter
- CCDC102B p.Ser177Asn Uncertain significance Single submitter
- CCDC102B p.Ser210Phe Uncertain significance Single submitter
- CCDC102B p.Ser492Ala Uncertain significance Single submitter
- CCDC102B p.Ser61Leu Uncertain significance Single submitter
- CCDC102B p.Thr155Pro Uncertain significance Single submitter
- CCDC102B p.Thr171Ala Uncertain significance Single submitter
- CCDC102B p.Thr195Ala Uncertain significance Single submitter
- CCDC102B p.Thr195Ile Uncertain significance Single submitter
- CCDC102B p.Thr199Ile Uncertain significance Single submitter
- CCDC102B p.Tyr299Cys Uncertain significance Single submitter
- CCDC102B p.Val164Leu Uncertain significance Single submitter
- CCDC102B p.Val207Phe Uncertain significance Single submitter
- CCDC102B p.Val451Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CCDC102B p.Glu370Gly Benign Multiple submitters
- CCDC102B p.Arg278His Uncertain significance Single submitter
- CCDC102B p.Arg399Gly Uncertain significance Single submitter
- CCDC102B p.Arg74Cys Uncertain significance Single submitter
- CCDC102B p.Arg76Trp Uncertain significance Single submitter
- CCDC102B p.Glu112Lys Uncertain significance Single submitter
- CCDC102B p.Glu128Gln Uncertain significance Single submitter
- CCDC102B p.Glu377Lys Uncertain significance Single submitter
- CCDC102B p.Ile6Arg Uncertain significance Single submitter
- CCDC102B p.Leu134Phe Uncertain significance Single submitter
- CCDC102B p.Leu416Pro Uncertain significance Single submitter
- CCDC102B p.Leu78Phe Uncertain significance Single submitter
- CCDC102B p.Ser290Pro Uncertain significance Single submitter
- CCDC102B p.Thr91Ser Uncertain significance Single submitter
- CCDC102B p.Trp67Cys Uncertain significance Single submitter
All CCDC102B variants
Benign 5
- p.Arg26= Multiple submitters
- p.Asn425Lys Multiple submitters
- p.Glu358Lys Multiple submitters
- p.Glu370Gly Multiple submitters ⚠
- p.Thr237Arg Multiple submitters
Likely benign 7
- p.Arg26His Single submitter
- p.Arg464Gln Single submitter
- p.Ile69= Single submitter
- p.Ser290= Single submitter
- p.Ser361Leu Single submitter
- p.Thr237Met Single submitter
- p.Tyr187Cys Single submitter
Uncertain significance 81
- p.Ala100Val Single submitter ⚠
- p.Ala149Val Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Ala85Gly Single submitter
- p.Ala86Ser Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg371Gly Single submitter ⚠
- p.Arg399Gly Single submitter ⚠
- p.Arg399Ile Single submitter ⚠
- p.Arg464Leu Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg76Trp Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Asn2Ser Single submitter ⚠
- p.Asn420His Single submitter ⚠
- p.Asn440Ser Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Asp38Gly Single submitter ⚠
- p.Asp38Val Single submitter ⚠
- p.Asp481Gly Single submitter ⚠
- p.Cys40Arg Single submitter ⚠
- p.Cys70Arg Single submitter ⚠
- p.Glu112Lys Single submitter ⚠
- p.Glu128Gln Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu186Asp Single submitter ⚠
- p.Glu216Ala Single submitter ⚠
- p.Glu282Val Single submitter ⚠
- p.Glu289Lys Single submitter ⚠
- p.Glu301Gln Single submitter ⚠
- p.Glu326Gly Single submitter ⚠
- p.Glu333Val Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu467Lys Single submitter ⚠
- p.Glu504Lys Single submitter ⚠
- p.Gly162Val Single submitter ⚠
- p.Gly233Arg Single submitter ⚠
- p.Gly235Ser Single submitter ⚠
- p.His181Arg Single submitter ⚠
- p.Ile15Leu Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Ile315Val Single submitter ⚠
- p.Ile368Thr Single submitter ⚠
- p.Ile368Val Single submitter ⚠
- p.Ile414Val Single submitter ⚠
- p.Ile6Arg Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Leu260Ser Single submitter ⚠
- p.Leu281Phe Single submitter ⚠
- p.Leu416Pro Single submitter ⚠
- p.Leu73Ile Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Lys244Glu Single submitter ⚠
- p.Lys373Asn Single submitter ⚠
- p.Lys388Thr Single submitter ⚠
- p.Lys475Asn Single submitter ⚠
- p.Met217Ile Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Met92Val Single submitter ⚠
- p.Pro219Thr Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Ser142Asn Single submitter ⚠
- p.Ser177Asn Single submitter ⚠
- p.Ser210Phe Single submitter ⚠
- p.Ser290Pro Single submitter ⚠
- p.Ser492Ala Single submitter ⚠
- p.Ser61Leu Single submitter ⚠
- p.Thr155Pro Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr195Ala Single submitter ⚠
- p.Thr195Ile Single submitter ⚠
- p.Thr199Ile Single submitter ⚠
- p.Thr91Ser Single submitter ⚠
- p.Trp67Cys Single submitter ⚠
- p.Tyr299Cys Single submitter ⚠
- p.Val164Leu Single submitter ⚠
- p.Val207Phe Single submitter ⚠
- p.Val451Leu Single submitter ⚠