CCDC106 — 38 ClinVar variants
All ClinVar germline CCDC106 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
38 Uncertain significance
Full CCDC106 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC106 p.Ala54Ser Uncertain significance Single submitter
- CCDC106 p.Ala56Val Uncertain significance Single submitter
- CCDC106 p.Arg109Trp Uncertain significance Single submitter
- CCDC106 p.Arg122Cys Uncertain significance Single submitter
- CCDC106 p.Arg122His Uncertain significance Single submitter
- CCDC106 p.Arg164His Uncertain significance Single submitter
- CCDC106 p.Arg280Gln Uncertain significance Single submitter
- CCDC106 p.Arg41Gln Uncertain significance Single submitter
- CCDC106 p.Arg42Ser Uncertain significance Single submitter
- CCDC106 p.Arg4Trp Uncertain significance Single submitter
- CCDC106 p.Arg71Lys Uncertain significance Single submitter
- CCDC106 p.Arg9Trp Uncertain significance Single submitter
- CCDC106 p.Asp13Asn Uncertain significance Single submitter
- CCDC106 p.Asp14Asn Uncertain significance Single submitter
- CCDC106 p.Asp30Ala Uncertain significance Single submitter
- CCDC106 p.Cys250Tyr Uncertain significance Single submitter
- CCDC106 p.Gln263Glu Uncertain significance Single submitter
- CCDC106 p.Glu144Gly Uncertain significance Single submitter
- CCDC106 p.Glu45Lys Uncertain significance Single submitter
- CCDC106 p.Gly126Ala Uncertain significance Single submitter
- CCDC106 p.Gly141Glu Uncertain significance Single submitter
- CCDC106 p.Leu222Pro Uncertain significance Single submitter
- CCDC106 p.Leu244Arg Uncertain significance Single submitter
- CCDC106 p.Lys169Gln Uncertain significance Single submitter
- CCDC106 p.Pro39His Uncertain significance Single submitter
- CCDC106 p.Pro39Ser Uncertain significance Single submitter
- CCDC106 p.Ser137Ala Uncertain significance Single submitter
- CCDC106 p.Ser138Phe Uncertain significance Single submitter
- CCDC106 p.Ser149Asn Uncertain significance Single submitter
- CCDC106 p.Ser149Gly Uncertain significance Single submitter
- CCDC106 p.Ser161Arg Uncertain significance Single submitter
- CCDC106 p.Ser38Asn Uncertain significance Single submitter
- CCDC106 p.Thr217Arg Uncertain significance Single submitter
- CCDC106 p.Thr63Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CCDC106 variants
Uncertain significance 38
- p.Ala264Glu Single submitter
- p.Ala54Ser Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Arg109Trp Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg171Trp Single submitter
- p.Arg280Gln Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg42Ser Single submitter ⚠
- p.Arg4Trp Single submitter ⚠
- p.Arg71Lys Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asp13Asn Single submitter ⚠
- p.Asp14Asn Single submitter ⚠
- p.Asp30Ala Single submitter ⚠
- p.Cys250Tyr Single submitter ⚠
- p.Gln263Glu Single submitter ⚠
- p.Glu144Gly Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Gly126Ala Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly191Arg Single submitter ⚠
- p.Leu222Pro Single submitter ⚠
- p.Leu244Arg Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Lys169Gln Single submitter ⚠
- p.Pro39His Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Ser137Ala Single submitter ⚠
- p.Ser138Phe Single submitter ⚠
- p.Ser149Asn Single submitter ⚠
- p.Ser149Gly Single submitter ⚠
- p.Ser161Arg Single submitter ⚠
- p.Ser38Asn Single submitter ⚠
- p.Thr217Arg Single submitter ⚠
- p.Thr63Ile Single submitter ⚠