CCDC107 — 59 ClinVar variants
All ClinVar germline CCDC107 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
7 Likely benign · 52 Uncertain significance
Full CCDC107 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC107 p.Ala118Gly Uncertain significance Single submitter
- CCDC107 p.Ala18Val Uncertain significance Single submitter
- CCDC107 p.Ala225Val Uncertain significance Single submitter
- CCDC107 p.Ala27Thr Uncertain significance Single submitter
- CCDC107 p.Ala70Ser Uncertain significance Single submitter
- CCDC107 p.Ala70Thr Uncertain significance Single submitter
- CCDC107 p.Ala77Thr Uncertain significance Single submitter
- CCDC107 p.Ala78Gly Uncertain significance Single submitter
- CCDC107 p.Arg137Cys Uncertain significance Single submitter
- CCDC107 p.Arg250Gln Uncertain significance Single submitter
- CCDC107 p.Arg250Trp Uncertain significance Single submitter
- CCDC107 p.Arg276Gln Uncertain significance Single submitter
- CCDC107 p.Arg49Gly Uncertain significance Single submitter
- CCDC107 p.Arg51Gln Uncertain significance Single submitter
- CCDC107 p.Arg58Pro Uncertain significance Single submitter
- CCDC107 p.Asp168Ala Uncertain significance Single submitter
- CCDC107 p.Asp210Asn Uncertain significance Single submitter
- CCDC107 p.Asp25Tyr Uncertain significance Single submitter
- CCDC107 p.Gln112His Uncertain significance Single submitter
- CCDC107 p.Gln115Glu Uncertain significance Single submitter
- CCDC107 p.Gln279His Uncertain significance Single submitter
- CCDC107 p.Glu170Lys Uncertain significance Single submitter
- CCDC107 p.Glu244Ala Uncertain significance Single submitter
- CCDC107 p.Gly177Asp Uncertain significance Single submitter
- CCDC107 p.Gly44Glu Uncertain significance Single submitter
- CCDC107 p.His263Pro Uncertain significance Single submitter
- CCDC107 p.Ile156Val Uncertain significance Single submitter
- CCDC107 p.Ile197Met Uncertain significance Single submitter
- CCDC107 p.Leu13Met Uncertain significance Single submitter
- CCDC107 p.Leu141Val Uncertain significance Single submitter
- CCDC107 p.Leu19Met Uncertain significance Single submitter
- CCDC107 p.Leu71Val Uncertain significance Single submitter
- CCDC107 p.Lys164Arg Uncertain significance Single submitter
- CCDC107 p.Met169Ile Uncertain significance Single submitter
- CCDC107 p.Pro174Ser Uncertain significance Single submitter
- CCDC107 p.Pro206Arg Uncertain significance Single submitter
- CCDC107 p.Pro52Ser Uncertain significance Single submitter
- CCDC107 p.Pro53Arg Uncertain significance Single submitter
- CCDC107 p.Ser163Ile Uncertain significance Single submitter
- CCDC107 p.Ser254Gly Uncertain significance Single submitter
- CCDC107 p.Ser264Cys Uncertain significance Single submitter
- CCDC107 p.Ser6Pro Uncertain significance Single submitter
- CCDC107 p.Thr139Ser Uncertain significance Single submitter
- CCDC107 p.Thr140Ala Uncertain significance Single submitter
- CCDC107 p.Thr192Ile Uncertain significance Single submitter
- CCDC107 p.Thr91Ser Uncertain significance Single submitter
- CCDC107 p.Val16Ala Uncertain significance Single submitter
- CCDC107 p.Val16Leu Uncertain significance Single submitter
- CCDC107 p.Val245Leu Uncertain significance Single submitter
- CCDC107 p.Val257Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CCDC107 variants
Likely benign 7
- p.Ala171Val Single submitter
- p.Gly175= Single submitter
- p.Gly3Ser Single submitter
- p.His157= Single submitter
- p.Leu160= Single submitter
- p.Ser178Leu Single submitter
- p.Trp237Arg Single submitter
Uncertain significance 52
- p.Ala118Gly Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala225Val Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala70Ser Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Ala77Thr Single submitter ⚠
- p.Ala78Gly Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg250Trp Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg49Gly Single submitter ⚠
- p.Arg51Gln Single submitter ⚠
- p.Arg58Pro Single submitter ⚠
- p.Asp168Ala Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp25Tyr Single submitter ⚠
- p.Gln112His Single submitter ⚠
- p.Gln115Glu Single submitter ⚠
- p.Gln279His Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu244Ala Single submitter ⚠
- p.Gly177Asp Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.Gly69Glu Single submitter ⚠
- p.His263Pro Single submitter ⚠
- p.Ile156Val Single submitter ⚠
- p.Ile197Met Single submitter ⚠
- p.Leu13Met Single submitter ⚠
- p.Leu141Val Single submitter ⚠
- p.Leu19Met Single submitter ⚠
- p.Leu71Val Single submitter ⚠
- p.Lys164Arg Single submitter ⚠
- p.Met169Ile Single submitter ⚠
- p.Phe195Leu Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro206Arg Single submitter ⚠
- p.Pro52Ser Single submitter ⚠
- p.Pro53Arg Single submitter ⚠
- p.Ser163Ile Single submitter ⚠
- p.Ser254Gly Single submitter ⚠
- p.Ser264Cys Single submitter ⚠
- p.Ser6Pro Single submitter ⚠
- p.Thr139Ser Single submitter ⚠
- p.Thr140Ala Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr91Ser Single submitter ⚠
- p.Val16Ala Single submitter ⚠
- p.Val16Leu Single submitter ⚠
- p.Val245Leu Single submitter ⚠
- p.Val257Met Single submitter ⚠