CCDC110 — 109 ClinVar variants
All ClinVar germline CCDC110 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
6 Likely benign · 103 Uncertain significance
Full CCDC110 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC110 p.Ala207Thr Uncertain significance Single submitter
- CCDC110 p.Ala654Ser Uncertain significance Single submitter
- CCDC110 p.Ala816Pro Uncertain significance Single submitter
- CCDC110 p.Arg202Cys Uncertain significance Single submitter
- CCDC110 p.Arg566Gln Uncertain significance Single submitter
- CCDC110 p.Arg660Lys Uncertain significance Single submitter
- CCDC110 p.Arg765Gln Uncertain significance Single submitter
- CCDC110 p.Asn120Ser Uncertain significance Single submitter
- CCDC110 p.Asn25Ile Uncertain significance Single submitter
- CCDC110 p.Asn304His Uncertain significance Single submitter
- CCDC110 p.Asn76Ser Uncertain significance Single submitter
- CCDC110 p.Asp11Val Uncertain significance Single submitter
- CCDC110 p.Asp370Asn Uncertain significance Single submitter
- CCDC110 p.Asp386Asn Uncertain significance Single submitter
- CCDC110 p.Asp818Gly Uncertain significance Single submitter
- CCDC110 p.Asp818Tyr Uncertain significance Single submitter
- CCDC110 p.Asp827Gly Uncertain significance Single submitter
- CCDC110 p.Cys35Phe Uncertain significance Single submitter
- CCDC110 p.Cys504Tyr Uncertain significance Single submitter
- CCDC110 p.Gln429Pro Uncertain significance Single submitter
- CCDC110 p.Gln768Glu Uncertain significance Single submitter
- CCDC110 p.Glu122Lys Uncertain significance Single submitter
- CCDC110 p.Glu412Lys Uncertain significance Single submitter
- CCDC110 p.Glu422Asp Uncertain significance Single submitter
- CCDC110 p.Glu422Lys Uncertain significance Single submitter
- CCDC110 p.Glu673Lys Uncertain significance Single submitter
- CCDC110 p.Glu795Gln Uncertain significance Single submitter
- CCDC110 p.Glu805Asp Uncertain significance Single submitter
- CCDC110 p.Glu805Lys Uncertain significance Single submitter
- CCDC110 p.Gly233Arg Uncertain significance Single submitter
- CCDC110 p.Gly233Glu Uncertain significance Single submitter
- CCDC110 p.Gly405Val Uncertain significance Single submitter
- CCDC110 p.Gly41Cys Uncertain significance Single submitter
- CCDC110 p.His725Arg Uncertain significance Single submitter
- CCDC110 p.His7Gln Uncertain significance Single submitter
- CCDC110 p.His833Tyr Uncertain significance Single submitter
- CCDC110 p.Ile112Val Uncertain significance Single submitter
- CCDC110 p.Ile23Leu Uncertain significance Single submitter
- CCDC110 p.Ile307Thr Uncertain significance Single submitter
- CCDC110 p.Ile470Val Uncertain significance Single submitter
- CCDC110 p.Ile490Val Uncertain significance Single submitter
- CCDC110 p.Ile50Leu Uncertain significance Single submitter
- CCDC110 p.Ile530Val Uncertain significance Single submitter
- CCDC110 p.Ile697Val Uncertain significance Single submitter
- CCDC110 p.Leu455Arg Uncertain significance Single submitter
- CCDC110 p.Leu534Ser Uncertain significance Single submitter
- CCDC110 p.Leu88Ser Uncertain significance Single submitter
- CCDC110 p.Lys280Arg Uncertain significance Single submitter
- CCDC110 p.Lys339Ile Uncertain significance Single submitter
- CCDC110 p.Lys509Glu Uncertain significance Single submitter
- CCDC110 p.Lys5Glu Uncertain significance Single submitter
- CCDC110 p.Lys723Glu Uncertain significance Single submitter
- CCDC110 p.Lys787Ile Uncertain significance Single submitter
- CCDC110 p.Met283Thr Uncertain significance Single submitter
- CCDC110 p.Met291Leu Uncertain significance Single submitter
- CCDC110 p.Met348Arg Uncertain significance Single submitter
- CCDC110 p.Met557Ile Uncertain significance Single submitter
- CCDC110 p.Met707Val Uncertain significance Single submitter
- CCDC110 p.Met71Arg Uncertain significance Single submitter
- CCDC110 p.Phe200Tyr Uncertain significance Single submitter
- CCDC110 p.Pro117Ala Uncertain significance Single submitter
- CCDC110 p.Pro208Ser Uncertain significance Single submitter
- CCDC110 p.Pro209Thr Uncertain significance Single submitter
- CCDC110 p.Pro3Leu Uncertain significance Single submitter
- CCDC110 p.Ser284Phe Uncertain significance Single submitter
- CCDC110 p.Ser346Arg Uncertain significance Single submitter
- CCDC110 p.Ser46Leu Uncertain significance Single submitter
- CCDC110 p.Ser65Ala Uncertain significance Single submitter
- CCDC110 p.Thr138Ile Uncertain significance Single submitter
- CCDC110 p.Thr576Ser Uncertain significance Single submitter
- CCDC110 p.Thr625Met Uncertain significance Single submitter
- CCDC110 p.Thr671Ile Uncertain significance Single submitter
- CCDC110 p.Thr740Asn Uncertain significance Single submitter
- CCDC110 p.Thr759Ala Uncertain significance Single submitter
- CCDC110 p.Tyr802Cys Uncertain significance Single submitter
- CCDC110 p.Val13Ile Uncertain significance Single submitter
- CCDC110 p.Val260Met Uncertain significance Single submitter
- CCDC110 p.Val420Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CCDC110 p.Ala68Asp Uncertain significance Single submitter
- CCDC110 p.Arg566Gly Uncertain significance Single submitter
- CCDC110 p.Glu526Gln Uncertain significance Single submitter
- CCDC110 p.Glu550Lys Uncertain significance Single submitter
- CCDC110 p.Ile581Thr Uncertain significance Single submitter
- CCDC110 p.Ile680Val Uncertain significance Single submitter
- CCDC110 p.Leu172Arg Uncertain significance Single submitter
- CCDC110 p.Leu453Pro Uncertain significance Single submitter
- CCDC110 p.Leu469Val Uncertain significance Single submitter
- CCDC110 p.Leu59Phe Uncertain significance Single submitter
- CCDC110 p.Leu630Pro Uncertain significance Single submitter
- CCDC110 p.Lys619Glu Uncertain significance Single submitter
- CCDC110 p.Met557Thr Uncertain significance Single submitter
- CCDC110 p.Ser130Gly Uncertain significance Single submitter
- CCDC110 p.Ser153Gly Uncertain significance Single submitter
- CCDC110 p.Ser21Phe Uncertain significance Single submitter
- CCDC110 p.Ser26Tyr Uncertain significance Single submitter
- CCDC110 p.Ser284Cys Uncertain significance Single submitter
- CCDC110 p.Ser383Phe Uncertain significance Single submitter
- CCDC110 p.Ser737Gly Uncertain significance Single submitter
- CCDC110 p.Ser82Leu Uncertain significance Single submitter
- CCDC110 p.Thr110Met Uncertain significance Single submitter
- CCDC110 p.Val473Ala Uncertain significance Single submitter
- CCDC110 p.Val708Ala Uncertain significance Single submitter
- CCDC110 p.Val80Ala Uncertain significance Single submitter
All CCDC110 variants
Likely benign 6
- p.Arg111His Single submitter
- p.Glu167Lys Single submitter
- p.Gly301Ser Single submitter
- p.Ser157Asn Single submitter
- p.Thr118Ile Single submitter
- p.Tyr380His Single submitter
Uncertain significance 103
- p.Ala207Thr Single submitter ⚠
- p.Ala654Ser Single submitter ⚠
- p.Ala68Asp Single submitter ⚠
- p.Ala816Pro Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg566Gln Single submitter ⚠
- p.Arg566Gly Single submitter ⚠
- p.Arg660Lys Single submitter ⚠
- p.Arg765Gln Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn25Ile Single submitter ⚠
- p.Asn304His Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Asp11Val Single submitter ⚠
- p.Asp370Asn Single submitter ⚠
- p.Asp386Asn Single submitter ⚠
- p.Asp818Gly Single submitter ⚠
- p.Asp818Tyr Single submitter ⚠
- p.Asp827Gly Single submitter ⚠
- p.Cys35Phe Single submitter ⚠
- p.Cys504Tyr Single submitter ⚠
- p.Gln429Pro Single submitter ⚠
- p.Gln768Glu Single submitter ⚠
- p.Glu122Lys Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu422Asp Single submitter ⚠
- p.Glu422Lys Single submitter ⚠
- p.Glu526Gln Single submitter ⚠
- p.Glu550Lys Single submitter ⚠
- p.Glu673Lys Single submitter ⚠
- p.Glu795Gln Single submitter ⚠
- p.Glu805Asp Single submitter ⚠
- p.Glu805Lys Single submitter ⚠
- p.Gly233Arg Single submitter ⚠
- p.Gly233Glu Single submitter ⚠
- p.Gly405Val Single submitter ⚠
- p.Gly41Cys Single submitter ⚠
- p.His725Arg Single submitter ⚠
- p.His7Gln Single submitter ⚠
- p.His833Tyr Single submitter ⚠
- p.Ile112Val Single submitter ⚠
- p.Ile23Leu Single submitter ⚠
- p.Ile307Thr Single submitter ⚠
- p.Ile470Val Single submitter ⚠
- p.Ile490Val Single submitter ⚠
- p.Ile50Leu Single submitter ⚠
- p.Ile530Val Single submitter ⚠
- p.Ile581Thr Single submitter ⚠
- p.Ile680Val Single submitter ⚠
- p.Ile697Val Single submitter ⚠
- p.Leu172Arg Single submitter ⚠
- p.Leu453Pro Single submitter ⚠
- p.Leu455Arg Single submitter ⚠
- p.Leu469Val Single submitter ⚠
- p.Leu534Ser Single submitter ⚠
- p.Leu59Phe Single submitter ⚠
- p.Leu630Pro Single submitter ⚠
- p.Leu88Ser Single submitter ⚠
- p.Lys280Arg Single submitter ⚠
- p.Lys339Ile Single submitter ⚠
- p.Lys509Glu Single submitter ⚠
- p.Lys5Glu Single submitter ⚠
- p.Lys619Glu Single submitter ⚠
- p.Lys723Glu Single submitter ⚠
- p.Lys787Ile Single submitter ⚠
- p.Met283Thr Single submitter ⚠
- p.Met291Leu Single submitter ⚠
- p.Met348Arg Single submitter ⚠
- p.Met557Ile Single submitter ⚠
- p.Met557Thr Single submitter ⚠
- p.Met707Val Single submitter ⚠
- p.Met71Arg Single submitter ⚠
- p.Phe200Tyr Single submitter ⚠
- p.Pro117Ala Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Pro209Thr Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Ser130Gly Single submitter ⚠
- p.Ser153Gly Single submitter ⚠
- p.Ser21Phe Single submitter ⚠
- p.Ser26Tyr Single submitter ⚠
- p.Ser284Cys Single submitter ⚠
- p.Ser284Phe Single submitter ⚠
- p.Ser346Arg Single submitter ⚠
- p.Ser383Phe Single submitter ⚠
- p.Ser46Leu Single submitter ⚠
- p.Ser65Ala Single submitter ⚠
- p.Ser737Gly Single submitter ⚠
- p.Ser82Leu Single submitter ⚠
- p.Thr110Met Single submitter ⚠
- p.Thr138Ile Single submitter ⚠
- p.Thr576Ser Single submitter ⚠
- p.Thr625Met Single submitter ⚠
- p.Thr671Ile Single submitter ⚠
- p.Thr740Asn Single submitter ⚠
- p.Thr759Ala Single submitter ⚠
- p.Tyr802Cys Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val260Met Single submitter ⚠
- p.Val420Ile Single submitter ⚠
- p.Val473Ala Single submitter ⚠
- p.Val708Ala Single submitter ⚠
- p.Val80Ala Single submitter ⚠