CCDC137 — 57 ClinVar variants
All ClinVar germline CCDC137 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
8 Likely benign · 49 Uncertain significance
Full CCDC137 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC137 p.Ala144Thr Uncertain significance Single submitter
- CCDC137 p.Ala9Val Uncertain significance Single submitter
- CCDC137 p.Arg12Ser Uncertain significance Single submitter
- CCDC137 p.Arg146Gln Uncertain significance Single submitter
- CCDC137 p.Arg170Gln Uncertain significance Single submitter
- CCDC137 p.Arg263Ser Uncertain significance Single submitter
- CCDC137 p.Arg276Gln Uncertain significance Single submitter
- CCDC137 p.Asn79Thr Uncertain significance Single submitter
- CCDC137 p.Asp108Asn Uncertain significance Single submitter
- CCDC137 p.Asp59Glu Uncertain significance Single submitter
- CCDC137 p.Gln134Arg Uncertain significance Single submitter
- CCDC137 p.Gln14His Uncertain significance Single submitter
- CCDC137 p.Glu156Gly Uncertain significance Single submitter
- CCDC137 p.Glu286Gln Uncertain significance Single submitter
- CCDC137 p.Gly199Arg Uncertain significance Single submitter
- CCDC137 p.Gly235Val Uncertain significance Single submitter
- CCDC137 p.Leu228Arg Uncertain significance Single submitter
- CCDC137 p.Lys115Arg Uncertain significance Single submitter
- CCDC137 p.Lys284Glu Uncertain significance Single submitter
- CCDC137 p.Met227Val Uncertain significance Single submitter
- CCDC137 p.Pro212Thr Uncertain significance Single submitter
- CCDC137 p.Pro39Leu Uncertain significance Single submitter
- CCDC137 p.Pro39Ser Uncertain significance Single submitter
- CCDC137 p.Ser11Cys Uncertain significance Single submitter
- CCDC137 p.Ser225Pro Uncertain significance Single submitter
- CCDC137 p.Thr280Ser Uncertain significance Single submitter
- CCDC137 p.Val237Glu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CCDC137 p.Arg247Cys Uncertain significance Multiple submitters
- CCDC137 p.Ala261Val Uncertain significance Single submitter
- CCDC137 p.Ala264Val Likely benign Single submitter
- CCDC137 p.Ala2Ser Uncertain significance Single submitter
- CCDC137 p.Ala2Val Uncertain significance Single submitter
- CCDC137 p.Ala9Glu Uncertain significance Single submitter
- CCDC137 p.Arg229Trp Uncertain significance Single submitter
- CCDC137 p.Arg249Gln Uncertain significance Single submitter
- CCDC137 p.Arg249Trp Uncertain significance Single submitter
- CCDC137 p.Arg257Gln Uncertain significance Single submitter
- CCDC137 p.Arg268Leu Likely benign Single submitter
- CCDC137 p.Arg6Cys Uncertain significance Single submitter
- CCDC137 p.Gln270Glu Uncertain significance Single submitter
- CCDC137 p.Gln271His Uncertain significance Single submitter
- CCDC137 p.Gly119Trp Likely benign Single submitter
- CCDC137 p.Leu272Pro Uncertain significance Single submitter
- CCDC137 p.Lys179Asn Uncertain significance Single submitter
- CCDC137 p.Lys266Gln Uncertain significance Single submitter
- CCDC137 p.Lys56Glu Uncertain significance Single submitter
- CCDC137 p.Met129Val Uncertain significance Single submitter
- CCDC137 p.Phe138Val Uncertain significance Single submitter
- CCDC137 p.Pro240Ser Uncertain significance Single submitter
- CCDC137 p.Ser11Tyr Uncertain significance Single submitter
- CCDC137 p.Ser82Gly Uncertain significance Single submitter
- CCDC137 p.Thr242Ile Uncertain significance Single submitter
All CCDC137 variants
Likely benign 8
- p.Ala166= Single submitter
- p.Ala264Val Single submitter ⚠
- p.Arg177Gln Single submitter
- p.Arg268Gln Single submitter
- p.Arg268Leu Single submitter ⚠
- p.Gly119Trp Single submitter ⚠
- p.Gly123Arg Single submitter
- p.Gly235Ser Single submitter
Uncertain significance 49
- p.Arg247Cys Multiple submitters ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala261Val Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala9Glu Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg12Ser Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg249Trp Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg263Ser Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Asn79Thr Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp59Glu Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Gln14His Single submitter ⚠
- p.Gln270Glu Single submitter ⚠
- p.Gln271His Single submitter ⚠
- p.Glu156Gly Single submitter ⚠
- p.Glu286Gln Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly235Val Single submitter ⚠
- p.Leu228Arg Single submitter ⚠
- p.Leu272Pro Single submitter ⚠
- p.Lys115Arg Single submitter ⚠
- p.Lys179Asn Single submitter ⚠
- p.Lys266Gln Single submitter ⚠
- p.Lys284Glu Single submitter ⚠
- p.Lys56Glu Single submitter ⚠
- p.Met129Val Single submitter ⚠
- p.Met227Val Single submitter ⚠
- p.Phe138Val Single submitter ⚠
- p.Pro212Thr Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Ser11Cys Single submitter ⚠
- p.Ser11Tyr Single submitter ⚠
- p.Ser225Pro Single submitter ⚠
- p.Ser82Gly Single submitter ⚠
- p.Thr242Ile Single submitter ⚠
- p.Thr280Ser Single submitter ⚠
- p.Val237Glu Single submitter ⚠