CCDC157 — 149 ClinVar variants
All ClinVar germline CCDC157 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 138 flagged for review →
11 Likely benign · 138 Uncertain significance
Full CCDC157 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 138
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC157 p.Ala292Val Uncertain significance Single submitter
- CCDC157 p.Ala300Thr Uncertain significance Single submitter
- CCDC157 p.Ala324Ser Uncertain significance Single submitter
- CCDC157 p.Ala32Thr Uncertain significance Single submitter
- CCDC157 p.Ala389Val Uncertain significance Single submitter
- CCDC157 p.Ala407Val Uncertain significance Single submitter
- CCDC157 p.Ala480Gly Uncertain significance Single submitter
- CCDC157 p.Ala613Val Uncertain significance Single submitter
- CCDC157 p.Ala9Gly Uncertain significance Single submitter
- CCDC157 p.Arg193Ser Uncertain significance Single submitter
- CCDC157 p.Arg265Gly Uncertain significance Single submitter
- CCDC157 p.Arg274Leu Uncertain significance Single submitter
- CCDC157 p.Arg31His Uncertain significance Single submitter
- CCDC157 p.Arg393Gly Uncertain significance Single submitter
- CCDC157 p.Arg393Lys Uncertain significance Single submitter
- CCDC157 p.Arg415Gln Uncertain significance Single submitter
- CCDC157 p.Arg738Gly Uncertain significance Single submitter
- CCDC157 p.Arg750Gln Uncertain significance Single submitter
- CCDC157 p.Arg750Pro Uncertain significance Single submitter
- CCDC157 p.Asp82Gly Uncertain significance Single submitter
- CCDC157 p.Cys184Arg Uncertain significance Single submitter
- CCDC157 p.Cys184Tyr Uncertain significance Single submitter
- CCDC157 p.Cys719Arg Uncertain significance Single submitter
- CCDC157 p.Gln243Arg Uncertain significance Single submitter
- CCDC157 p.Gln320Glu Uncertain significance Single submitter
- CCDC157 p.Gln372Arg Uncertain significance Single submitter
- CCDC157 p.Gln448Arg Uncertain significance Single submitter
- CCDC157 p.Gln501Arg Uncertain significance Single submitter
- CCDC157 p.Glu158Lys Uncertain significance Single submitter
- CCDC157 p.Glu474Lys Uncertain significance Single submitter
- CCDC157 p.Glu476Lys Uncertain significance Single submitter
- CCDC157 p.Glu553Lys Uncertain significance Single submitter
- CCDC157 p.Glu749Lys Uncertain significance Single submitter
- CCDC157 p.Gly131Ser Uncertain significance Single submitter
- CCDC157 p.Gly33Arg Uncertain significance Single submitter
- CCDC157 p.Gly418Ala Uncertain significance Single submitter
- CCDC157 p.Gly559Ser Uncertain significance Single submitter
- CCDC157 p.Gly617Ser Uncertain significance Single submitter
- CCDC157 p.Gly633Arg Uncertain significance Single submitter
- CCDC157 p.Gly64Asp Uncertain significance Single submitter
- CCDC157 p.Gly667Ala Uncertain significance Single submitter
- CCDC157 p.His134Gln Uncertain significance Single submitter
- CCDC157 p.His557Arg Uncertain significance Single submitter
- CCDC157 p.His73Arg Uncertain significance Single submitter
- CCDC157 p.Ile568Met Uncertain significance Single submitter
- CCDC157 p.Leu507Pro Uncertain significance Single submitter
- CCDC157 p.Leu595Pro Uncertain significance Single submitter
- CCDC157 p.Leu84Pro Uncertain significance Single submitter
- CCDC157 p.Lys156Arg Uncertain significance Single submitter
- CCDC157 p.Lys288Asn Uncertain significance Single submitter
- CCDC157 p.Lys377Glu Uncertain significance Single submitter
- CCDC157 p.Met262Val Uncertain significance Single submitter
- CCDC157 p.Met92Ile Uncertain significance Single submitter
- CCDC157 p.Pro105Arg Uncertain significance Single submitter
- CCDC157 p.Pro105Ser Uncertain significance Single submitter
- CCDC157 p.Pro106Leu Uncertain significance Single submitter
- CCDC157 p.Pro137Leu Uncertain significance Single submitter
- CCDC157 p.Pro163Ser Uncertain significance Single submitter
- CCDC157 p.Pro38Arg Uncertain significance Single submitter
- CCDC157 p.Pro622Leu Uncertain significance Single submitter
- CCDC157 p.Pro747His Uncertain significance Single submitter
- CCDC157 p.Ser126Arg Uncertain significance Single submitter
- CCDC157 p.Ser162Arg Uncertain significance Single submitter
- CCDC157 p.Ser427Gly Uncertain significance Single submitter
- CCDC157 p.Ser488Arg Uncertain significance Single submitter
- CCDC157 p.Thr216Met Uncertain significance Single submitter
- CCDC157 p.Thr428Arg Uncertain significance Single submitter
- CCDC157 p.Thr552Ala Uncertain significance Single submitter
- CCDC157 p.Trp275Arg Uncertain significance Single submitter
- CCDC157 p.Val577Ile Uncertain significance Single submitter
Predictors split 68
The independent predictors disagree with each other — read with care.
- CCDC157 p.Arg45Leu Uncertain significance Multiple submitters
- CCDC157 p.Ala223Pro Uncertain significance Single submitter
- CCDC157 p.Ala317Thr Uncertain significance Single submitter
- CCDC157 p.Ala391Val Uncertain significance Single submitter
- CCDC157 p.Ala74Asp Uncertain significance Single submitter
- CCDC157 p.Arg121Gln Uncertain significance Single submitter
- CCDC157 p.Arg121Trp Uncertain significance Single submitter
- CCDC157 p.Arg122His Uncertain significance Single submitter
- CCDC157 p.Arg129Ser Uncertain significance Single submitter
- CCDC157 p.Arg15Cys Uncertain significance Single submitter
- CCDC157 p.Arg285Cys Uncertain significance Single submitter
- CCDC157 p.Arg31Cys Uncertain significance Single submitter
- CCDC157 p.Arg325Gln Uncertain significance Single submitter
- CCDC157 p.Arg36Cys Uncertain significance Single submitter
- CCDC157 p.Arg387Cys Uncertain significance Single submitter
- CCDC157 p.Arg387His Uncertain significance Single submitter
- CCDC157 p.Arg436His Uncertain significance Single submitter
- CCDC157 p.Arg442Cys Uncertain significance Single submitter
- CCDC157 p.Arg45His Uncertain significance Single submitter
- CCDC157 p.Arg465Cys Uncertain significance Single submitter
- CCDC157 p.Arg465His Uncertain significance Single submitter
- CCDC157 p.Arg469Trp Uncertain significance Single submitter
- CCDC157 p.Arg479Gln Uncertain significance Single submitter
- CCDC157 p.Arg490Gln Uncertain significance Single submitter
- CCDC157 p.Arg498Thr Uncertain significance Single submitter
- CCDC157 p.Arg522Trp Uncertain significance Single submitter
- CCDC157 p.Arg530Trp Uncertain significance Single submitter
- CCDC157 p.Arg591His Uncertain significance Single submitter
- CCDC157 p.Arg593Trp Uncertain significance Single submitter
- CCDC157 p.Arg601Trp Uncertain significance Single submitter
- CCDC157 p.Arg625Trp Uncertain significance Single submitter
- CCDC157 p.Arg675Gln Uncertain significance Single submitter
- CCDC157 p.Arg691Gln Uncertain significance Single submitter
- CCDC157 p.Arg691Pro Uncertain significance Single submitter
- CCDC157 p.Arg699Trp Uncertain significance Single submitter
- CCDC157 p.Arg738Trp Uncertain significance Single submitter
- CCDC157 p.Arg750Trp Uncertain significance Single submitter
- CCDC157 p.Asp438Asn Uncertain significance Single submitter
- CCDC157 p.Asp49Asn Uncertain significance Single submitter
- CCDC157 p.Gln334His Uncertain significance Single submitter
- CCDC157 p.Gln410Pro Uncertain significance Single submitter
- CCDC157 p.Glu278Lys Uncertain significance Single submitter
- CCDC157 p.Glu349Gly Uncertain significance Single submitter
- CCDC157 p.Glu392Asp Uncertain significance Single submitter
- CCDC157 p.Glu445Val Uncertain significance Single submitter
- CCDC157 p.Glu483Asp Uncertain significance Single submitter
- CCDC157 p.Glu489Lys Uncertain significance Single submitter
- CCDC157 p.Glu67Lys Uncertain significance Single submitter
- CCDC157 p.Leu458Arg Uncertain significance Single submitter
- CCDC157 p.Leu486Arg Uncertain significance Single submitter
- CCDC157 p.Leu541Met Uncertain significance Single submitter
- CCDC157 p.Phe29Leu Uncertain significance Single submitter
- CCDC157 p.Pro63Leu Uncertain significance Single submitter
- CCDC157 p.Pro66Ser Uncertain significance Single submitter
- CCDC157 p.Pro677Ser Uncertain significance Single submitter
- CCDC157 p.Pro693Arg Uncertain significance Single submitter
- CCDC157 p.Pro701Arg Uncertain significance Single submitter
- CCDC157 p.Ser151Tyr Uncertain significance Single submitter
- CCDC157 p.Ser659Asn Uncertain significance Single submitter
- CCDC157 p.Thr201Met Uncertain significance Single submitter
- CCDC157 p.Thr428Met Uncertain significance Single submitter
- CCDC157 p.Thr519Met Uncertain significance Single submitter
- CCDC157 p.Thr661Met Uncertain significance Single submitter
- CCDC157 p.Thr664Ile Uncertain significance Single submitter
- CCDC157 p.Thr695Lys Uncertain significance Single submitter
- CCDC157 p.Val26Ile Uncertain significance Single submitter
- CCDC157 p.Val28Ile Uncertain significance Single submitter
- CCDC157 p.Val409Leu Uncertain significance Single submitter
All CCDC157 variants
Likely benign 11
- p.Ala517Val Single submitter
- p.Arg368Gln Single submitter
- p.Arg469Gln Single submitter
- p.Glu417Asp Single submitter
- p.Gly385Ala Single submitter
- p.Gly420Ser Single submitter
- p.Leu666Pro Single submitter
- p.Lys204Arg Single submitter
- p.Lys732Arg Single submitter
- p.Pro268= Single submitter
- p.Ser698Pro Single submitter
Uncertain significance 138
- p.Arg45Leu Multiple submitters ⚠
- p.Ala223Pro Single submitter ⚠
- p.Ala292Val Single submitter ⚠
- p.Ala300Thr Single submitter ⚠
- p.Ala317Thr Single submitter ⚠
- p.Ala324Ser Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala407Val Single submitter ⚠
- p.Ala480Gly Single submitter ⚠
- p.Ala613Val Single submitter ⚠
- p.Ala74Asp Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg121Trp Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg129Ser Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg193Ser Single submitter ⚠
- p.Arg265Gly Single submitter ⚠
- p.Arg274Leu Single submitter ⚠
- p.Arg285Cys Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Arg325Gln Single submitter ⚠
- p.Arg36Cys Single submitter ⚠
- p.Arg387Cys Single submitter ⚠
- p.Arg387His Single submitter ⚠
- p.Arg393Gly Single submitter ⚠
- p.Arg393Lys Single submitter ⚠
- p.Arg415Gln Single submitter ⚠
- p.Arg436His Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg45His Single submitter ⚠
- p.Arg465Cys Single submitter ⚠
- p.Arg465His Single submitter ⚠
- p.Arg469Trp Single submitter ⚠
- p.Arg479Gln Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg498Thr Single submitter ⚠
- p.Arg522Trp Single submitter ⚠
- p.Arg530Trp Single submitter ⚠
- p.Arg591His Single submitter ⚠
- p.Arg593Trp Single submitter ⚠
- p.Arg601Trp Single submitter ⚠
- p.Arg625Trp Single submitter ⚠
- p.Arg675Gln Single submitter ⚠
- p.Arg691Gln Single submitter ⚠
- p.Arg691Pro Single submitter ⚠
- p.Arg699Trp Single submitter ⚠
- p.Arg738Gly Single submitter ⚠
- p.Arg738Trp Single submitter ⚠
- p.Arg750Gln Single submitter ⚠
- p.Arg750Pro Single submitter ⚠
- p.Arg750Trp Single submitter ⚠
- p.Asp438Asn Single submitter ⚠
- p.Asp49Asn Single submitter ⚠
- p.Asp82Gly Single submitter ⚠
- p.Cys184Arg Single submitter ⚠
- p.Cys184Tyr Single submitter ⚠
- p.Cys719Arg Single submitter ⚠
- p.Gln243Arg Single submitter ⚠
- p.Gln320Glu Single submitter ⚠
- p.Gln334His Single submitter ⚠
- p.Gln372Arg Single submitter ⚠
- p.Gln410Pro Single submitter ⚠
- p.Gln448Arg Single submitter ⚠
- p.Gln501Arg Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Glu278Lys Single submitter ⚠
- p.Glu349Gly Single submitter ⚠
- p.Glu392Asp Single submitter ⚠
- p.Glu445Val Single submitter ⚠
- p.Glu474Lys Single submitter ⚠
- p.Glu476Lys Single submitter ⚠
- p.Glu483Asp Single submitter ⚠
- p.Glu489Lys Single submitter ⚠
- p.Glu553Lys Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Glu749Lys Single submitter ⚠
- p.Gly131Ser Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly418Ala Single submitter ⚠
- p.Gly559Ser Single submitter ⚠
- p.Gly617Ser Single submitter ⚠
- p.Gly633Arg Single submitter ⚠
- p.Gly64Asp Single submitter ⚠
- p.Gly667Ala Single submitter ⚠
- p.His134Gln Single submitter ⚠
- p.His557Arg Single submitter ⚠
- p.His73Arg Single submitter ⚠
- p.Ile568Met Single submitter ⚠
- p.Leu458Arg Single submitter ⚠
- p.Leu486Arg Single submitter ⚠
- p.Leu507Pro Single submitter ⚠
- p.Leu541Met Single submitter ⚠
- p.Leu595Pro Single submitter ⚠
- p.Leu84Pro Single submitter ⚠
- p.Lys156Arg Single submitter ⚠
- p.Lys288Asn Single submitter ⚠
- p.Lys377Glu Single submitter ⚠
- p.Met262Val Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Phe29Leu Single submitter ⚠
- p.Pro105Arg Single submitter ⚠
- p.Pro105Ser Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro163Ser Single submitter ⚠
- p.Pro38Arg Single submitter ⚠
- p.Pro622Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Pro677Ser Single submitter ⚠
- p.Pro693Arg Single submitter ⚠
- p.Pro701Arg Single submitter ⚠
- p.Pro747His Single submitter ⚠
- p.Ser126Arg Single submitter ⚠
- p.Ser151Tyr Single submitter ⚠
- p.Ser162Arg Single submitter ⚠
- p.Ser427Gly Single submitter ⚠
- p.Ser488Arg Single submitter ⚠
- p.Ser659Asn Single submitter ⚠
- p.Thr201Met Single submitter ⚠
- p.Thr216Met Single submitter ⚠
- p.Thr428Arg Single submitter ⚠
- p.Thr428Met Single submitter ⚠
- p.Thr519Met Single submitter ⚠
- p.Thr552Ala Single submitter ⚠
- p.Thr661Met Single submitter ⚠
- p.Thr664Ile Single submitter ⚠
- p.Thr695Lys Single submitter ⚠
- p.Trp275Arg Single submitter ⚠
- p.Val26Ile Single submitter ⚠
- p.Val28Ile Single submitter ⚠
- p.Val409Leu Single submitter ⚠
- p.Val577Ile Single submitter ⚠