CCDC158 — 172 ClinVar variants
All ClinVar germline CCDC158 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 169 flagged for review →
4 Likely benign · 168 Uncertain significance
Full CCDC158 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 169
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC158 p.Ala1046Pro Uncertain significance Single submitter
- CCDC158 p.Ala336Ser Uncertain significance Single submitter
- CCDC158 p.Ala451Thr Uncertain significance Single submitter
- CCDC158 p.Ala468Asp Uncertain significance Single submitter
- CCDC158 p.Ala618Thr Uncertain significance Single submitter
- CCDC158 p.Ala704Thr Uncertain significance Single submitter
- CCDC158 p.Ala704Val Uncertain significance Single submitter
- CCDC158 p.Ala729Pro Uncertain significance Single submitter
- CCDC158 p.Ala782Asp Uncertain significance Single submitter
- CCDC158 p.Ala782Ser Uncertain significance Single submitter
- CCDC158 p.Ala920Thr Uncertain significance Single submitter
- CCDC158 p.Ala936Asp Uncertain significance Single submitter
- CCDC158 p.Ala936Gly Uncertain significance Single submitter
- CCDC158 p.Arg1014His Uncertain significance Single submitter
- CCDC158 p.Arg1044Lys Uncertain significance Single submitter
- CCDC158 p.Arg176Gln Uncertain significance Single submitter
- CCDC158 p.Arg190Gln Uncertain significance Single submitter
- CCDC158 p.Arg216Cys Uncertain significance Single submitter
- CCDC158 p.Arg35Cys Uncertain significance Single submitter
- CCDC158 p.Arg35His Uncertain significance Single submitter
- CCDC158 p.Arg406Gln Uncertain significance Single submitter
- CCDC158 p.Arg419Gln Uncertain significance Single submitter
- CCDC158 p.Arg448Gln Uncertain significance Single submitter
- CCDC158 p.Arg583Gln Uncertain significance Single submitter
- CCDC158 p.Arg621Gln Uncertain significance Single submitter
- CCDC158 p.Arg684Gln Uncertain significance Single submitter
- CCDC158 p.Arg684Leu Uncertain significance Single submitter
- CCDC158 p.Arg801Cys Uncertain significance Single submitter
- CCDC158 p.Arg801His Uncertain significance Single submitter
- CCDC158 p.Arg862His Uncertain significance Single submitter
- CCDC158 p.Arg871His Uncertain significance Single submitter
- CCDC158 p.Asn1017Ser Uncertain significance Single submitter
- CCDC158 p.Asn295Ser Uncertain significance Single submitter
- CCDC158 p.Asn516Ser Uncertain significance Single submitter
- CCDC158 p.Asn786Lys Uncertain significance Single submitter
- CCDC158 p.Asp12Val Uncertain significance Single submitter
- CCDC158 p.Asp601Glu Uncertain significance Single submitter
- CCDC158 p.Asp62Gly Uncertain significance Single submitter
- CCDC158 p.Asp968Gly Uncertain significance Single submitter
- CCDC158 p.Cys205Arg Uncertain significance Single submitter
- CCDC158 p.Cys823Arg Uncertain significance Single submitter
- CCDC158 p.Gln1092Arg Uncertain significance Single submitter
- CCDC158 p.Gln120Glu Uncertain significance Single submitter
- CCDC158 p.Gln138Arg Uncertain significance Single submitter
- CCDC158 p.Gln140Lys Uncertain significance Single submitter
- CCDC158 p.Glu1064Gly Uncertain significance Single submitter
- CCDC158 p.Glu198Lys Uncertain significance Single submitter
- CCDC158 p.Glu259Asp Uncertain significance Single submitter
- CCDC158 p.Glu532Lys Uncertain significance Single submitter
- CCDC158 p.Glu565Asp Uncertain significance Single submitter
- CCDC158 p.Glu754Gly Uncertain significance Single submitter
- CCDC158 p.Glu77Gln Uncertain significance Single submitter
- CCDC158 p.Glu927Lys Uncertain significance Single submitter
- CCDC158 p.Glu977Ala Uncertain significance Single submitter
- CCDC158 p.Gly852Arg Uncertain significance Single submitter
- CCDC158 p.His1026Pro Uncertain significance Single submitter
- CCDC158 p.His1050Arg Uncertain significance Single submitter
- CCDC158 p.His416Arg Uncertain significance Single submitter
- CCDC158 p.Ile113Thr Uncertain significance Single submitter
- CCDC158 p.Ile132Val Uncertain significance Single submitter
- CCDC158 p.Ile304Val Uncertain significance Single submitter
- CCDC158 p.Ile34Val Uncertain significance Single submitter
- CCDC158 p.Ile39Thr Uncertain significance Single submitter
- CCDC158 p.Ile915Val Uncertain significance Single submitter
- CCDC158 p.Leu393Pro Uncertain significance Single submitter
- CCDC158 p.Lys1056Glu Uncertain significance Single submitter
- CCDC158 p.Lys1068Glu Uncertain significance Single submitter
- CCDC158 p.Lys1090Arg Uncertain significance Single submitter
- CCDC158 p.Lys177Glu Uncertain significance Single submitter
- CCDC158 p.Lys203Arg Uncertain significance Single submitter
- CCDC158 p.Lys391Thr Uncertain significance Single submitter
- CCDC158 p.Lys615Asn Uncertain significance Single submitter
- CCDC158 p.Lys787Arg Uncertain significance Single submitter
- CCDC158 p.Pro69Thr Uncertain significance Single submitter
- CCDC158 p.Pro877Leu Uncertain significance Single submitter
- CCDC158 p.Pro919Thr Uncertain significance Single submitter
- CCDC158 p.Ser1005Thr Uncertain significance Single submitter
- CCDC158 p.Ser209Arg Uncertain significance Single submitter
- CCDC158 p.Ser217Arg Uncertain significance Single submitter
- CCDC158 p.Ser21Thr Uncertain significance Single submitter
- CCDC158 p.Ser288Asn Uncertain significance Single submitter
- CCDC158 p.Ser464Pro Uncertain significance Single submitter
- CCDC158 p.Ser973Asn Uncertain significance Single submitter
- CCDC158 p.Thr170Ile Uncertain significance Single submitter
- CCDC158 p.Thr42Ile Uncertain significance Single submitter
- CCDC158 p.Thr49Ile Uncertain significance Single submitter
- CCDC158 p.Thr49Pro Uncertain significance Single submitter
- CCDC158 p.Thr780Ser Uncertain significance Single submitter
- CCDC158 p.Thr985Arg Uncertain significance Single submitter
- CCDC158 p.Val185Glu Uncertain significance Single submitter
- CCDC158 p.Val546Leu Uncertain significance Single submitter
- CCDC158 p.Val590Ala Uncertain significance Single submitter
- CCDC158 p.Val59Met Uncertain significance Single submitter
- CCDC158 p.Val648Ala Uncertain significance Single submitter
- CCDC158 p.Val678Ile Uncertain significance Single submitter
- CCDC158 p.Val781Leu Uncertain significance Single submitter
- CCDC158 p.Val869Ile Uncertain significance Single submitter
Predictors split 72
The independent predictors disagree with each other — read with care.
- CCDC158 p.Ala452Ser Uncertain significance Single submitter
- CCDC158 p.Arg190Trp Uncertain significance Single submitter
- CCDC158 p.Arg317His Uncertain significance Single submitter
- CCDC158 p.Arg330Cys Uncertain significance Single submitter
- CCDC158 p.Arg365His Uncertain significance Single submitter
- CCDC158 p.Arg424Gln Uncertain significance Single submitter
- CCDC158 p.Arg430His Uncertain significance Single submitter
- CCDC158 p.Arg478His Uncertain significance Single submitter
- CCDC158 p.Arg621Trp Uncertain significance Single submitter
- CCDC158 p.Arg644Trp Uncertain significance Single submitter
- CCDC158 p.Arg646His Uncertain significance Single submitter
- CCDC158 p.Arg681Gly Uncertain significance Single submitter
- CCDC158 p.Arg836His Uncertain significance Single submitter
- CCDC158 p.Asn1091Asp Uncertain significance Single submitter
- CCDC158 p.Asn423His Uncertain significance Single submitter
- CCDC158 p.Asp167Gly Uncertain significance Single submitter
- CCDC158 p.Asp903Gly Uncertain significance Single submitter
- CCDC158 p.Cys1070Phe Uncertain significance Single submitter
- CCDC158 p.Cys823Tyr Uncertain significance Single submitter
- CCDC158 p.Gln380Glu Uncertain significance Single submitter
- CCDC158 p.Gln86His Uncertain significance Single submitter
- CCDC158 p.Glu162Gln Uncertain significance Single submitter
- CCDC158 p.Glu162Lys Uncertain significance Single submitter
- CCDC158 p.Glu197Gly Uncertain significance Single submitter
- CCDC158 p.Glu206Gln Uncertain significance Single submitter
- CCDC158 p.Glu371Lys Uncertain significance Single submitter
- CCDC158 p.Glu427Gly Uncertain significance Single submitter
- CCDC158 p.Glu458Ala Uncertain significance Single submitter
- CCDC158 p.Glu471Ala Uncertain significance Single submitter
- CCDC158 p.Glu471Gln Uncertain significance Single submitter
- CCDC158 p.Glu495Gly Uncertain significance Single submitter
- CCDC158 p.Glu518Gln Uncertain significance Single submitter
- CCDC158 p.Glu518Lys Uncertain significance Single submitter
- CCDC158 p.Glu633Lys Uncertain significance Single submitter
- CCDC158 p.Glu661Lys Uncertain significance Single submitter
- CCDC158 p.Glu675Asp Likely benign Single submitter
- CCDC158 p.Glu689Ala Uncertain significance Single submitter
- CCDC158 p.Glu707Gln Uncertain significance Single submitter
- CCDC158 p.Glu719Lys Uncertain significance Single submitter
- CCDC158 p.His214Tyr Uncertain significance Single submitter
- CCDC158 p.His535Tyr Uncertain significance Single submitter
- CCDC158 p.His724Arg Uncertain significance Single submitter
- CCDC158 p.Ile258Thr Uncertain significance Single submitter
- CCDC158 p.Ile743Val Uncertain significance Single submitter
- CCDC158 p.Leu180Phe Uncertain significance Single submitter
- CCDC158 p.Leu272Ser Uncertain significance Single submitter
- CCDC158 p.Leu379Arg Uncertain significance Single submitter
- CCDC158 p.Lys251Asn Uncertain significance Single submitter
- CCDC158 p.Lys592Ile Uncertain significance Single submitter
- CCDC158 p.Lys619Asn Uncertain significance Single submitter
- CCDC158 p.Lys785Glu Uncertain significance Single submitter
- CCDC158 p.Met588Thr Uncertain significance Single submitter
- CCDC158 p.Met730Ile Uncertain significance Single submitter
- CCDC158 p.Phe766Ser Uncertain significance Single submitter
- CCDC158 p.Ser1018Tyr Uncertain significance Single submitter
- CCDC158 p.Ser1045Phe Uncertain significance Single submitter
- CCDC158 p.Ser1095Pro Uncertain significance Single submitter
- CCDC158 p.Ser137Arg Uncertain significance Single submitter
- CCDC158 p.Ser21Pro Uncertain significance Single submitter
- CCDC158 p.Ser32Thr Uncertain significance Single submitter
- CCDC158 p.Ser394Arg Uncertain significance Single submitter
- CCDC158 p.Ser63Phe Uncertain significance Single submitter
- CCDC158 p.Ser884Gly Uncertain significance Single submitter
- CCDC158 p.Ser922Phe Uncertain significance Single submitter
- CCDC158 p.Ser953Ile Uncertain significance Single submitter
- CCDC158 p.Thr1030Ile Uncertain significance Single submitter
- CCDC158 p.Thr281Ile Uncertain significance Single submitter
- CCDC158 p.Thr467Ala Uncertain significance Single submitter
- CCDC158 p.Thr497Ile Uncertain significance Single submitter
- CCDC158 p.Thr694Lys Uncertain significance Single submitter
- CCDC158 p.Val835Ala Uncertain significance Single submitter
- CCDC158 p.Gln1101Lys Uncertain significance No assertion criteria
All CCDC158 variants
Likely benign 4
- p.Ala988Thr Single submitter
- p.Glu675Asp Single submitter ⚠
- p.Gly1035Asp Single submitter
- p.Thr344Ile Single submitter
Uncertain significance 168
- p.Ala1046Pro Single submitter ⚠
- p.Ala336Ser Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala452Ser Single submitter ⚠
- p.Ala468Asp Single submitter ⚠
- p.Ala618Thr Single submitter ⚠
- p.Ala704Thr Single submitter ⚠
- p.Ala704Val Single submitter ⚠
- p.Ala729Pro Single submitter ⚠
- p.Ala782Asp Single submitter ⚠
- p.Ala782Ser Single submitter ⚠
- p.Ala920Thr Single submitter ⚠
- p.Ala936Asp Single submitter ⚠
- p.Ala936Gly Single submitter ⚠
- p.Arg1014His Single submitter ⚠
- p.Arg1044Lys Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg190Trp Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg330Cys Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg424Gln Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Arg448Gln Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg583Gln Single submitter ⚠
- p.Arg621Gln Single submitter ⚠
- p.Arg621Trp Single submitter ⚠
- p.Arg644Trp Single submitter ⚠
- p.Arg646His Single submitter ⚠
- p.Arg681Gly Single submitter ⚠
- p.Arg684Gln Single submitter ⚠
- p.Arg684Leu Single submitter ⚠
- p.Arg801Cys Single submitter ⚠
- p.Arg801His Single submitter ⚠
- p.Arg836His Single submitter ⚠
- p.Arg862His Single submitter ⚠
- p.Arg871His Single submitter ⚠
- p.Asn1017Ser Single submitter ⚠
- p.Asn1091Asp Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn423His Single submitter ⚠
- p.Asn516Ser Single submitter ⚠
- p.Asn786Lys Single submitter ⚠
- p.Asp12Val Single submitter ⚠
- p.Asp167Gly Single submitter ⚠
- p.Asp601Glu Single submitter ⚠
- p.Asp62Gly Single submitter ⚠
- p.Asp903Gly Single submitter ⚠
- p.Asp968Gly Single submitter ⚠
- p.Cys1070Phe Single submitter ⚠
- p.Cys205Arg Single submitter ⚠
- p.Cys823Arg Single submitter ⚠
- p.Cys823Tyr Single submitter ⚠
- p.Gln1092Arg Single submitter ⚠
- p.Gln120Glu Single submitter ⚠
- p.Gln138Arg Single submitter ⚠
- p.Gln140Lys Single submitter ⚠
- p.Gln380Glu Single submitter ⚠
- p.Gln86His Single submitter ⚠
- p.Glu1064Gly Single submitter ⚠
- p.Glu162Gln Single submitter ⚠
- p.Glu162Lys Single submitter ⚠
- p.Glu197Gly Single submitter ⚠
- p.Glu198Lys Single submitter ⚠
- p.Glu206Gln Single submitter ⚠
- p.Glu259Asp Single submitter ⚠
- p.Glu371Lys Single submitter ⚠
- p.Glu427Gly Single submitter ⚠
- p.Glu458Ala Single submitter ⚠
- p.Glu471Ala Single submitter ⚠
- p.Glu471Gln Single submitter ⚠
- p.Glu495Gly Single submitter ⚠
- p.Glu518Gln Single submitter ⚠
- p.Glu518Lys Single submitter ⚠
- p.Glu532Lys Single submitter ⚠
- p.Glu565Asp Single submitter ⚠
- p.Glu633Lys Single submitter ⚠
- p.Glu661Lys Single submitter ⚠
- p.Glu689Ala Single submitter ⚠
- p.Glu707Gln Single submitter ⚠
- p.Glu719Lys Single submitter ⚠
- p.Glu754Gly Single submitter ⚠
- p.Glu77Gln Single submitter ⚠
- p.Glu927Lys Single submitter ⚠
- p.Glu977Ala Single submitter ⚠
- p.Gly852Arg Single submitter ⚠
- p.His1026Pro Single submitter ⚠
- p.His1050Arg Single submitter ⚠
- p.His214Tyr Single submitter ⚠
- p.His416Arg Single submitter ⚠
- p.His535Tyr Single submitter ⚠
- p.His724Arg Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile132Val Single submitter ⚠
- p.Ile258Thr Single submitter ⚠
- p.Ile304Val Single submitter ⚠
- p.Ile34Val Single submitter ⚠
- p.Ile39Thr Single submitter ⚠
- p.Ile743Val Single submitter ⚠
- p.Ile915Val Single submitter ⚠
- p.Leu180Phe Single submitter ⚠
- p.Leu272Ser Single submitter ⚠
- p.Leu379Arg Single submitter ⚠
- p.Leu393Pro Single submitter ⚠
- p.Lys1056Glu Single submitter ⚠
- p.Lys1068Glu Single submitter ⚠
- p.Lys1090Arg Single submitter ⚠
- p.Lys177Glu Single submitter ⚠
- p.Lys203Arg Single submitter ⚠
- p.Lys251Asn Single submitter ⚠
- p.Lys391Thr Single submitter ⚠
- p.Lys592Ile Single submitter ⚠
- p.Lys615Asn Single submitter ⚠
- p.Lys619Asn Single submitter ⚠
- p.Lys785Glu Single submitter ⚠
- p.Lys787Arg Single submitter ⚠
- p.Met588Thr Single submitter ⚠
- p.Met730Ile Single submitter ⚠
- p.Phe766Ser Single submitter ⚠
- p.Pro69Thr Single submitter ⚠
- p.Pro877Leu Single submitter ⚠
- p.Pro919Thr Single submitter ⚠
- p.Ser1005Thr Single submitter ⚠
- p.Ser1018Tyr Single submitter ⚠
- p.Ser1045Phe Single submitter ⚠
- p.Ser1095Pro Single submitter ⚠
- p.Ser137Arg Single submitter ⚠
- p.Ser209Arg Single submitter ⚠
- p.Ser217Arg Single submitter ⚠
- p.Ser21Pro Single submitter ⚠
- p.Ser21Thr Single submitter ⚠
- p.Ser288Asn Single submitter ⚠
- p.Ser32Thr Single submitter ⚠
- p.Ser394Arg Single submitter ⚠
- p.Ser464Pro Single submitter ⚠
- p.Ser63Phe Single submitter ⚠
- p.Ser884Gly Single submitter ⚠
- p.Ser922Phe Single submitter ⚠
- p.Ser953Ile Single submitter ⚠
- p.Ser973Asn Single submitter ⚠
- p.Thr1030Ile Single submitter ⚠
- p.Thr170Ile Single submitter ⚠
- p.Thr281Ile Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr467Ala Single submitter ⚠
- p.Thr497Ile Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Thr49Pro Single submitter ⚠
- p.Thr694Lys Single submitter ⚠
- p.Thr780Ser Single submitter ⚠
- p.Thr985Arg Single submitter ⚠
- p.Val185Glu Single submitter ⚠
- p.Val546Leu Single submitter ⚠
- p.Val590Ala Single submitter ⚠
- p.Val59Met Single submitter ⚠
- p.Val648Ala Single submitter ⚠
- p.Val678Ile Single submitter ⚠
- p.Val781Leu Single submitter ⚠
- p.Val835Ala Single submitter ⚠
- p.Val869Ile Single submitter ⚠
- p.Gln1101Lys No assertion criteria ⚠