CCDC159 — 48 ClinVar variants
All ClinVar germline CCDC159 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Likely benign · 46 Uncertain significance
Full CCDC159 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC159 p.Ala203Thr Uncertain significance Single submitter
- CCDC159 p.Arg124Trp Uncertain significance Single submitter
- CCDC159 p.Arg126Gly Uncertain significance Single submitter
- CCDC159 p.Arg139Gln Uncertain significance Single submitter
- CCDC159 p.Arg153Gln Uncertain significance Single submitter
- CCDC159 p.Arg188His Uncertain significance Single submitter
- CCDC159 p.Arg257Thr Uncertain significance Single submitter
- CCDC159 p.Arg292His Uncertain significance Single submitter
- CCDC159 p.Arg83Cys Uncertain significance Single submitter
- CCDC159 p.Arg83His Uncertain significance Single submitter
- CCDC159 p.Arg98Trp Uncertain significance Single submitter
- CCDC159 p.Glu121Asp Uncertain significance Single submitter
- CCDC159 p.Glu137Gly Uncertain significance Single submitter
- CCDC159 p.Glu3Gln Uncertain significance Single submitter
- CCDC159 p.Gly248Arg Uncertain significance Single submitter
- CCDC159 p.Gly85Glu Uncertain significance Single submitter
- CCDC159 p.His234Gln Uncertain significance Single submitter
- CCDC159 p.His262Leu Uncertain significance Single submitter
- CCDC159 p.Ile229Arg Uncertain significance Single submitter
- CCDC159 p.Lys189Arg Uncertain significance Single submitter
- CCDC159 p.Lys252Glu Uncertain significance Single submitter
- CCDC159 p.Lys91Arg Uncertain significance Single submitter
- CCDC159 p.Met59Leu Uncertain significance Single submitter
- CCDC159 p.Pro205Leu Uncertain significance Single submitter
- CCDC159 p.Ser227Asn Uncertain significance Single submitter
- CCDC159 p.Ser254Leu Uncertain significance Single submitter
- CCDC159 p.Thr183Met Uncertain significance Single submitter
- CCDC159 p.Tyr102Ser Uncertain significance Single submitter
- CCDC159 p.Val235Met Uncertain significance Single submitter
- CCDC159 p.Val57Gly Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CCDC159 p.Ala45Asp Uncertain significance Single submitter
- CCDC159 p.Arg117Cys Uncertain significance Single submitter
- CCDC159 p.Arg117His Uncertain significance Single submitter
- CCDC159 p.Arg139Trp Uncertain significance Single submitter
- CCDC159 p.Arg98Pro Uncertain significance Single submitter
- CCDC159 p.Asp275Asn Uncertain significance Single submitter
- CCDC159 p.Asp277Asn Uncertain significance Single submitter
- CCDC159 p.Glu51Lys Uncertain significance Single submitter
- CCDC159 p.Ile177Thr Uncertain significance Single submitter
- CCDC159 p.Ile240Arg Uncertain significance Single submitter
- CCDC159 p.Ile240Thr Uncertain significance Single submitter
- CCDC159 p.Ser239Ala Uncertain significance Single submitter
- CCDC159 p.Ser239Pro Uncertain significance Single submitter
- CCDC159 p.Ser247Leu Likely benign Single submitter
- CCDC159 p.Thr201Ile Uncertain significance Single submitter
- CCDC159 p.Thr244Ile Uncertain significance Single submitter
- CCDC159 p.Thr81Ile Uncertain significance Single submitter
All CCDC159 variants
Likely benign 2
- p.Cys250Arg Single submitter
- p.Ser247Leu Single submitter ⚠
Uncertain significance 46
- p.Ala203Thr Single submitter ⚠
- p.Ala45Asp Single submitter ⚠
- p.Arg117Cys Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg126Gly Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg139Trp Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg257Thr Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Arg83His Single submitter ⚠
- p.Arg98Pro Single submitter ⚠
- p.Arg98Trp Single submitter ⚠
- p.Asp275Asn Single submitter ⚠
- p.Asp277Asn Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu137Gly Single submitter ⚠
- p.Glu3Gln Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Gly248Arg Single submitter ⚠
- p.Gly85Glu Single submitter ⚠
- p.His234Gln Single submitter ⚠
- p.His262Leu Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Ile229Arg Single submitter ⚠
- p.Ile240Arg Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Lys189Arg Single submitter ⚠
- p.Lys252Glu Single submitter ⚠
- p.Lys91Arg Single submitter ⚠
- p.Met59Leu Single submitter ⚠
- p.Pro205Leu Single submitter ⚠
- p.Ser227Asn Single submitter ⚠
- p.Ser239Ala Single submitter ⚠
- p.Ser239Pro Single submitter ⚠
- p.Ser254Leu Single submitter ⚠
- p.Thr183Met Single submitter ⚠
- p.Thr201Ile Single submitter ⚠
- p.Thr244Ile Single submitter ⚠
- p.Thr81Ile Single submitter ⚠
- p.Tyr102Ser Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val57Gly Single submitter ⚠