CCDC166 — 84 ClinVar variants
All ClinVar germline CCDC166 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
4 Likely benign · 80 Uncertain significance
Full CCDC166 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC166 p.Ala113Asp Uncertain significance Single submitter
- CCDC166 p.Ala31Thr Uncertain significance Single submitter
- CCDC166 p.Ala39Ser Uncertain significance Single submitter
- CCDC166 p.Ala430Asp Uncertain significance Single submitter
- CCDC166 p.Arg159Gln Uncertain significance Single submitter
- CCDC166 p.Arg204Ser Uncertain significance Single submitter
- CCDC166 p.Arg411Gln Uncertain significance Single submitter
- CCDC166 p.Arg413Trp Uncertain significance Single submitter
- CCDC166 p.Arg64Gly Uncertain significance Single submitter
- CCDC166 p.Asn427Ser Uncertain significance Single submitter
- CCDC166 p.Asp412His Uncertain significance Single submitter
- CCDC166 p.Gln108Arg Uncertain significance Single submitter
- CCDC166 p.Glu129Gly Uncertain significance Single submitter
- CCDC166 p.Glu206Gly Uncertain significance Single submitter
- CCDC166 p.Glu260Ala Uncertain significance Single submitter
- CCDC166 p.Glu29Gln Uncertain significance Single submitter
- CCDC166 p.Gly16Asp Uncertain significance Single submitter
- CCDC166 p.Gly17Asp Uncertain significance Single submitter
- CCDC166 p.Gly225Arg Uncertain significance Single submitter
- CCDC166 p.Gly225Glu Uncertain significance Single submitter
- CCDC166 p.Gly270Asp Uncertain significance Single submitter
- CCDC166 p.Gly275Asp Uncertain significance Single submitter
- CCDC166 p.Gly277Ala Uncertain significance Single submitter
- CCDC166 p.His167Arg Uncertain significance Single submitter
- CCDC166 p.Ile158Val Uncertain significance Single submitter
- CCDC166 p.Ile220Val Uncertain significance Single submitter
- CCDC166 p.Leu150Pro Uncertain significance Single submitter
- CCDC166 p.Lys404Gln Uncertain significance Single submitter
- CCDC166 p.Lys89Glu Uncertain significance Single submitter
- CCDC166 p.Met342Val Uncertain significance Single submitter
- CCDC166 p.Phe287Leu Uncertain significance Single submitter
- CCDC166 p.Pro276Ala Uncertain significance Single submitter
- CCDC166 p.Pro279Leu Uncertain significance Single submitter
- CCDC166 p.Ser323Leu Uncertain significance Single submitter
- CCDC166 p.Ser384Leu Uncertain significance Single submitter
- CCDC166 p.Ser51Asn Uncertain significance Single submitter
- CCDC166 p.Val179Met Uncertain significance Single submitter
- CCDC166 p.Val210Glu Uncertain significance Single submitter
- CCDC166 p.Val426Ala Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- CCDC166 p.Ala160Thr Likely benign Single submitter
- CCDC166 p.Ala219Val Uncertain significance Single submitter
- CCDC166 p.Ala222Ser Uncertain significance Single submitter
- CCDC166 p.Ala434Val Uncertain significance Single submitter
- CCDC166 p.Arg119Gly Uncertain significance Single submitter
- CCDC166 p.Arg159Pro Uncertain significance Single submitter
- CCDC166 p.Arg207Pro Uncertain significance Single submitter
- CCDC166 p.Arg211Cys Uncertain significance Single submitter
- CCDC166 p.Arg228Gln Uncertain significance Single submitter
- CCDC166 p.Arg236Cys Uncertain significance Single submitter
- CCDC166 p.Arg245Trp Uncertain significance Single submitter
- CCDC166 p.Arg252Cys Uncertain significance Single submitter
- CCDC166 p.Arg257Cys Uncertain significance Single submitter
- CCDC166 p.Arg273Cys Uncertain significance Single submitter
- CCDC166 p.Arg284Trp Uncertain significance Single submitter
- CCDC166 p.Arg293His Uncertain significance Single submitter
- CCDC166 p.Arg317Ser Uncertain significance Single submitter
- CCDC166 p.Arg321Gln Uncertain significance Single submitter
- CCDC166 p.Arg321Trp Uncertain significance Single submitter
- CCDC166 p.Arg329Leu Uncertain significance Single submitter
- CCDC166 p.Arg357Gln Uncertain significance Single submitter
- CCDC166 p.Arg369Gln Uncertain significance Single submitter
- CCDC166 p.Arg36Ser Uncertain significance Single submitter
- CCDC166 p.Arg397Cys Uncertain significance Single submitter
- CCDC166 p.Arg74Gln Uncertain significance Single submitter
- CCDC166 p.Arg99Pro Uncertain significance Single submitter
- CCDC166 p.Asp121Asn Uncertain significance Single submitter
- CCDC166 p.Glu164Lys Uncertain significance Single submitter
- CCDC166 p.Glu71Gly Uncertain significance Single submitter
- CCDC166 p.Glu96Lys Uncertain significance Single submitter
- CCDC166 p.Gly118Trp Uncertain significance Single submitter
- CCDC166 p.Gly367Val Uncertain significance Single submitter
- CCDC166 p.His242Tyr Uncertain significance Single submitter
- CCDC166 p.Leu69Pro Uncertain significance Single submitter
- CCDC166 p.Lys5Gln Uncertain significance Single submitter
- CCDC166 p.Met137Ile Uncertain significance Single submitter
- CCDC166 p.Phe190Leu Uncertain significance Single submitter
- CCDC166 p.Pro327Ser Likely benign Single submitter
- CCDC166 p.Pro3Ser Uncertain significance Single submitter
- CCDC166 p.Ser292Leu Uncertain significance Single submitter
- CCDC166 p.Ser328Leu Likely benign Single submitter
- CCDC166 p.Ser332Phe Uncertain significance Single submitter
- CCDC166 p.Ser78Arg Uncertain significance Single submitter
- CCDC166 p.Val55Gly Uncertain significance Single submitter
All CCDC166 variants
Likely benign 4
- p.Ala160Thr Single submitter ⚠
- p.Ala428Thr Single submitter
- p.Pro327Ser Single submitter ⚠
- p.Ser328Leu Single submitter ⚠
Uncertain significance 80
- p.Ala113Asp Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala222Ser Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Ala39Ser Single submitter ⚠
- p.Ala430Asp Single submitter ⚠
- p.Ala434Val Single submitter ⚠
- p.Arg119Gly Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg159Pro Single submitter ⚠
- p.Arg204Ser Single submitter ⚠
- p.Arg207Pro Single submitter ⚠
- p.Arg211Cys Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg245Trp Single submitter ⚠
- p.Arg252Cys Single submitter ⚠
- p.Arg257Cys Single submitter ⚠
- p.Arg273Cys Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Arg293His Single submitter ⚠
- p.Arg317Ser Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg329Leu Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg369Gln Single submitter ⚠
- p.Arg36Ser Single submitter ⚠
- p.Arg397Cys Single submitter ⚠
- p.Arg411Gln Single submitter ⚠
- p.Arg413Trp Single submitter ⚠
- p.Arg64Gly Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg99Pro Single submitter ⚠
- p.Asn427Ser Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp412His Single submitter ⚠
- p.Gln108Arg Single submitter ⚠
- p.Glu129Gly Single submitter ⚠
- p.Glu164Lys Single submitter ⚠
- p.Glu206Gly Single submitter ⚠
- p.Glu260Ala Single submitter ⚠
- p.Glu29Gln Single submitter ⚠
- p.Glu71Gly Single submitter ⚠
- p.Glu96Lys Single submitter ⚠
- p.Gly118Trp Single submitter ⚠
- p.Gly16Asp Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Gly225Arg Single submitter ⚠
- p.Gly225Glu Single submitter ⚠
- p.Gly270Asp Single submitter ⚠
- p.Gly275Asp Single submitter ⚠
- p.Gly277Ala Single submitter ⚠
- p.Gly367Val Single submitter ⚠
- p.His167Arg Single submitter ⚠
- p.His242Tyr Single submitter ⚠
- p.Ile158Val Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Leu150Pro Single submitter ⚠
- p.Leu69Pro Single submitter ⚠
- p.Lys404Gln Single submitter ⚠
- p.Lys5Gln Single submitter ⚠
- p.Lys89Glu Single submitter ⚠
- p.Met137Ile Single submitter ⚠
- p.Met342Val Single submitter ⚠
- p.Phe190Leu Single submitter ⚠
- p.Phe287Leu Single submitter ⚠
- p.Pro276Ala Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Ser292Leu Single submitter ⚠
- p.Ser323Leu Single submitter ⚠
- p.Ser332Phe Single submitter ⚠
- p.Ser384Leu Single submitter ⚠
- p.Ser51Asn Single submitter ⚠
- p.Ser78Arg Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val210Glu Single submitter ⚠
- p.Val426Ala Single submitter ⚠
- p.Val55Gly Single submitter ⚠