CCDC17 — 116 ClinVar variants
All ClinVar germline CCDC17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 112 flagged for review →
1 Benign · 4 Likely benign · 111 Uncertain significance
Full CCDC17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 112
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC17 p.Ala146Thr Uncertain significance Single submitter
- CCDC17 p.Ala146Val Uncertain significance Single submitter
- CCDC17 p.Ala197Val Uncertain significance Single submitter
- CCDC17 p.Ala289Gly Uncertain significance Single submitter
- CCDC17 p.Ala410Asp Uncertain significance Single submitter
- CCDC17 p.Ala433Val Uncertain significance Single submitter
- CCDC17 p.Ala487Thr Uncertain significance Single submitter
- CCDC17 p.Ala51Ser Uncertain significance Single submitter
- CCDC17 p.Arg191Gly Uncertain significance Single submitter
- CCDC17 p.Arg328Gln Uncertain significance Single submitter
- CCDC17 p.Arg406Trp Uncertain significance Single submitter
- CCDC17 p.Arg423Leu Uncertain significance Single submitter
- CCDC17 p.Arg430Lys Uncertain significance Single submitter
- CCDC17 p.Arg504Gln Uncertain significance Single submitter
- CCDC17 p.Arg504Trp Uncertain significance Single submitter
- CCDC17 p.Arg594His Uncertain significance Single submitter
- CCDC17 p.Asp332Glu Uncertain significance Single submitter
- CCDC17 p.Asp342Glu Uncertain significance Single submitter
- CCDC17 p.Asp424Asn Uncertain significance Single submitter
- CCDC17 p.Asp604His Uncertain significance Single submitter
- CCDC17 p.Asp76Glu Uncertain significance Single submitter
- CCDC17 p.Cys452Gly Uncertain significance Single submitter
- CCDC17 p.Gln124Arg Uncertain significance Single submitter
- CCDC17 p.Glu41Gly Uncertain significance Single submitter
- CCDC17 p.Gly185Arg Uncertain significance Single submitter
- CCDC17 p.Gly198Arg Uncertain significance Single submitter
- CCDC17 p.Gly265Ala Uncertain significance Single submitter
- CCDC17 p.Gly290Arg Uncertain significance Single submitter
- CCDC17 p.Gly294Arg Uncertain significance Single submitter
- CCDC17 p.Gly331Arg Uncertain significance Single submitter
- CCDC17 p.Gly367Ala Uncertain significance Single submitter
- CCDC17 p.Gly388Val Uncertain significance Single submitter
- CCDC17 p.Gly526Glu Uncertain significance Single submitter
- CCDC17 p.Gly6Ala Uncertain significance Single submitter
- CCDC17 p.Gly6Glu Uncertain significance Single submitter
- CCDC17 p.His4Asn Uncertain significance Single submitter
- CCDC17 p.Ile35Val Uncertain significance Single submitter
- CCDC17 p.Leu375Pro Uncertain significance Single submitter
- CCDC17 p.Leu434Phe Uncertain significance Single submitter
- CCDC17 p.Leu440Arg Uncertain significance Single submitter
- CCDC17 p.Leu554Pro Uncertain significance Single submitter
- CCDC17 p.Lys85Asn Uncertain significance Single submitter
- CCDC17 p.Met152Ile Uncertain significance Single submitter
- CCDC17 p.Met315Lys Uncertain significance Single submitter
- CCDC17 p.Met386Thr Uncertain significance Single submitter
- CCDC17 p.Met449Ile Uncertain significance Single submitter
- CCDC17 p.Met449Leu Uncertain significance Single submitter
- CCDC17 p.Phe20Cys Uncertain significance Single submitter
- CCDC17 p.Pro233Leu Uncertain significance Single submitter
- CCDC17 p.Pro337Thr Uncertain significance Single submitter
- CCDC17 p.Pro344Ser Uncertain significance Single submitter
- CCDC17 p.Pro349Leu Uncertain significance Single submitter
- CCDC17 p.Pro391Ala Uncertain significance Single submitter
- CCDC17 p.Pro592Ser Uncertain significance Single submitter
- CCDC17 p.Pro71His Uncertain significance Single submitter
- CCDC17 p.Pro75Ala Uncertain significance Single submitter
- CCDC17 p.Pro8Leu Uncertain significance Single submitter
- CCDC17 p.Ser293Leu Uncertain significance Single submitter
- CCDC17 p.Ser293Pro Uncertain significance Single submitter
- CCDC17 p.Ser361Leu Uncertain significance Single submitter
- CCDC17 p.Ser507Thr Uncertain significance Single submitter
- CCDC17 p.Ser524Gly Uncertain significance Single submitter
- CCDC17 p.Ser561Asn Uncertain significance Single submitter
- CCDC17 p.Thr284Ala Uncertain significance Single submitter
- CCDC17 p.Thr431Ala Uncertain significance Single submitter
- CCDC17 p.Trp268Arg Uncertain significance Single submitter
- CCDC17 p.Trp493Cys Uncertain significance Single submitter
- CCDC17 p.Tyr392Cys Uncertain significance Single submitter
- CCDC17 p.Val172Ala Uncertain significance Single submitter
- CCDC17 p.Val234Glu Uncertain significance Single submitter
- CCDC17 p.Val571Ala Uncertain significance Single submitter
Predictors split 41
The independent predictors disagree with each other — read with care.
- CCDC17 p.Ala154Thr Uncertain significance Single submitter
- CCDC17 p.Ala195Ser Uncertain significance Single submitter
- CCDC17 p.Ala546Pro Uncertain significance Single submitter
- CCDC17 p.Arg201Trp Uncertain significance Single submitter
- CCDC17 p.Arg21Cys Uncertain significance Single submitter
- CCDC17 p.Arg21His Uncertain significance Single submitter
- CCDC17 p.Arg304Gln Likely benign Single submitter
- CCDC17 p.Arg305Cys Uncertain significance Single submitter
- CCDC17 p.Arg319Trp Uncertain significance Single submitter
- CCDC17 p.Arg426Trp Uncertain significance Single submitter
- CCDC17 p.Arg504Pro Uncertain significance Single submitter
- CCDC17 p.Arg509Cys Uncertain significance Single submitter
- CCDC17 p.Arg509His Uncertain significance Single submitter
- CCDC17 p.Arg511Cys Uncertain significance Single submitter
- CCDC17 p.Arg511His Uncertain significance Single submitter
- CCDC17 p.Arg515Trp Uncertain significance Single submitter
- CCDC17 p.Arg542Gln Uncertain significance Single submitter
- CCDC17 p.Arg542Trp Uncertain significance Single submitter
- CCDC17 p.Asp424Tyr Uncertain significance Single submitter
- CCDC17 p.Cys474Ser Uncertain significance Single submitter
- CCDC17 p.Gln314Pro Uncertain significance Single submitter
- CCDC17 p.Gly258Ala Uncertain significance Single submitter
- CCDC17 p.Gly397Ser Uncertain significance Single submitter
- CCDC17 p.Gly425Glu Uncertain significance Single submitter
- CCDC17 p.His64Tyr Uncertain significance Single submitter
- CCDC17 p.Leu166Pro Uncertain significance Single submitter
- CCDC17 p.Leu222Met Uncertain significance Single submitter
- CCDC17 p.Leu296Pro Uncertain significance Single submitter
- CCDC17 p.Leu96Pro Uncertain significance Single submitter
- CCDC17 p.Pro239Leu Uncertain significance Single submitter
- CCDC17 p.Pro394Arg Uncertain significance Single submitter
- CCDC17 p.Pro462Thr Uncertain significance Single submitter
- CCDC17 p.Ser119Cys Uncertain significance Single submitter
- CCDC17 p.Ser133Gly Uncertain significance Single submitter
- CCDC17 p.Ser5Cys Uncertain significance Single submitter
- CCDC17 p.Ser82Cys Uncertain significance Single submitter
- CCDC17 p.Thr176Lys Uncertain significance Single submitter
- CCDC17 p.Thr241Ile Uncertain significance Single submitter
- CCDC17 p.Val415Met Uncertain significance Single submitter
- CCDC17 p.Val571Met Uncertain significance Single submitter
- CCDC17 p.Val60Met Uncertain significance Single submitter
All CCDC17 variants
Benign 1
- p.Val470Ile Single submitter
Likely benign 4
- p.Arg304Gln Single submitter ⚠
- p.Met42Val Single submitter
- p.Pro347Ser Single submitter
- p.Thr574Ser Single submitter
Uncertain significance 111
- p.Ala146Thr Single submitter ⚠
- p.Ala146Val Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala195Ser Single submitter ⚠
- p.Ala197Val Single submitter ⚠
- p.Ala289Gly Single submitter ⚠
- p.Ala410Asp Single submitter ⚠
- p.Ala433Val Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala51Ser Single submitter ⚠
- p.Ala546Pro Single submitter ⚠
- p.Arg191Gly Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg21His Single submitter ⚠
- p.Arg305Cys Single submitter ⚠
- p.Arg319Trp Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg406Trp Single submitter ⚠
- p.Arg423Leu Single submitter ⚠
- p.Arg426Trp Single submitter ⚠
- p.Arg430Lys Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg504Pro Single submitter ⚠
- p.Arg504Trp Single submitter ⚠
- p.Arg509Cys Single submitter ⚠
- p.Arg509His Single submitter ⚠
- p.Arg511Cys Single submitter ⚠
- p.Arg511His Single submitter ⚠
- p.Arg515Trp Single submitter ⚠
- p.Arg542Gln Single submitter ⚠
- p.Arg542Trp Single submitter ⚠
- p.Arg594His Single submitter ⚠
- p.Asp332Glu Single submitter ⚠
- p.Asp342Glu Single submitter ⚠
- p.Asp424Asn Single submitter ⚠
- p.Asp424Tyr Single submitter ⚠
- p.Asp604His Single submitter ⚠
- p.Asp76Glu Single submitter ⚠
- p.Cys452Gly Single submitter ⚠
- p.Cys474Ser Single submitter ⚠
- p.Gln124Arg Single submitter ⚠
- p.Gln314Pro Single submitter ⚠
- p.Glu41Gly Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly258Ala Single submitter ⚠
- p.Gly265Ala Single submitter ⚠
- p.Gly290Arg Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly331Arg Single submitter ⚠
- p.Gly367Ala Single submitter ⚠
- p.Gly388Val Single submitter ⚠
- p.Gly397Ser Single submitter ⚠
- p.Gly425Glu Single submitter ⚠
- p.Gly526Glu Single submitter ⚠
- p.Gly6Ala Single submitter ⚠
- p.Gly6Glu Single submitter ⚠
- p.His4Asn Single submitter ⚠
- p.His64Tyr Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Leu166Pro Single submitter ⚠
- p.Leu222Met Single submitter ⚠
- p.Leu296Pro Single submitter ⚠
- p.Leu375Pro Single submitter ⚠
- p.Leu434Phe Single submitter ⚠
- p.Leu440Arg Single submitter ⚠
- p.Leu554Pro Single submitter ⚠
- p.Leu96Pro Single submitter ⚠
- p.Lys85Asn Single submitter ⚠
- p.Met152Ile Single submitter ⚠
- p.Met315Lys Single submitter ⚠
- p.Met386Thr Single submitter ⚠
- p.Met449Ile Single submitter ⚠
- p.Met449Leu Single submitter ⚠
- p.Phe20Cys Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro239Leu Single submitter ⚠
- p.Pro337Thr Single submitter ⚠
- p.Pro344Ser Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Pro391Ala Single submitter ⚠
- p.Pro394Arg Single submitter ⚠
- p.Pro462Thr Single submitter ⚠
- p.Pro592Ser Single submitter ⚠
- p.Pro71His Single submitter ⚠
- p.Pro75Ala Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser119Cys Single submitter ⚠
- p.Ser133Gly Single submitter ⚠
- p.Ser293Leu Single submitter ⚠
- p.Ser293Pro Single submitter ⚠
- p.Ser361Leu Single submitter ⚠
- p.Ser507Thr Single submitter ⚠
- p.Ser524Gly Single submitter ⚠
- p.Ser561Asn Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Ser82Cys Single submitter ⚠
- p.Thr176Lys Single submitter ⚠
- p.Thr241Ile Single submitter ⚠
- p.Thr284Ala Single submitter ⚠
- p.Thr431Ala Single submitter ⚠
- p.Trp268Arg Single submitter ⚠
- p.Trp493Cys Single submitter ⚠
- p.Tyr392Cys Single submitter ⚠
- p.Val172Ala Single submitter ⚠
- p.Val234Glu Single submitter ⚠
- p.Val415Met Single submitter ⚠
- p.Val571Ala Single submitter ⚠
- p.Val571Met Single submitter ⚠
- p.Val60Met Single submitter ⚠