CCDC170 — 104 ClinVar variants
All ClinVar germline CCDC170 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
2 Conflicting · 4 Benign · 2 Likely benign · 96 Uncertain significance
Full CCDC170 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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CCDC170 p.Val604Ile
Conflicting
Single submitter
CCDC170-related condition
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC170 p.Ala17Glu Uncertain significance Single submitter
- CCDC170 p.Ala17Val Uncertain significance Single submitter
- CCDC170 p.Ala246Ser Uncertain significance Single submitter
- CCDC170 p.Ala315Glu Uncertain significance Single submitter
- CCDC170 p.Ala694Asp Uncertain significance Single submitter
- CCDC170 p.Arg201Ser Uncertain significance Single submitter
- CCDC170 p.Arg32Gly Uncertain significance Single submitter
- CCDC170 p.Arg32Pro Uncertain significance Single submitter
- CCDC170 p.Arg422Gln Uncertain significance Single submitter
- CCDC170 p.Arg457Gln Uncertain significance Single submitter
- CCDC170 p.Arg470Gly Uncertain significance Single submitter
- CCDC170 p.Arg508Gln Uncertain significance Single submitter
- CCDC170 p.Arg521Cys Uncertain significance Single submitter
- CCDC170 p.Arg67Gln Uncertain significance Single submitter
- CCDC170 p.Asn399Ser Uncertain significance Single submitter
- CCDC170 p.Asn567Ser Uncertain significance Single submitter
- CCDC170 p.Asp23Asn Uncertain significance Single submitter
- CCDC170 p.Asp23Gly Uncertain significance Single submitter
- CCDC170 p.Asp356Tyr Uncertain significance Single submitter
- CCDC170 p.Asp4Glu Uncertain significance Single submitter
- CCDC170 p.Asp565Asn Uncertain significance Single submitter
- CCDC170 p.Asp565His Uncertain significance Single submitter
- CCDC170 p.Asp65Ala Uncertain significance Single submitter
- CCDC170 p.Cys249Tyr Uncertain significance Single submitter
- CCDC170 p.Cys552Phe Uncertain significance Single submitter
- CCDC170 p.Gln285Glu Uncertain significance Single submitter
- CCDC170 p.Gln388Arg Uncertain significance Single submitter
- CCDC170 p.Glu20Gly Uncertain significance Single submitter
- CCDC170 p.Glu498Gln Uncertain significance Single submitter
- CCDC170 p.Glu614Lys Uncertain significance Single submitter
- CCDC170 p.Glu704Lys Uncertain significance Single submitter
- CCDC170 p.Glu79Ala Uncertain significance Single submitter
- CCDC170 p.His410Gln Uncertain significance Single submitter
- CCDC170 p.His532Tyr Uncertain significance Single submitter
- CCDC170 p.His710Leu Uncertain significance Single submitter
- CCDC170 p.Ile626Thr Uncertain significance Single submitter
- CCDC170 p.Leu608Pro Uncertain significance Single submitter
- CCDC170 p.Lys158Glu Uncertain significance Single submitter
- CCDC170 p.Lys510Arg Uncertain significance Single submitter
- CCDC170 p.Lys69Gln Uncertain significance Single submitter
- CCDC170 p.Phe277Ser Uncertain significance Single submitter
- CCDC170 p.Phe435Leu Uncertain significance Single submitter
- CCDC170 p.Ser262Arg Uncertain significance Single submitter
- CCDC170 p.Ser325Leu Uncertain significance Single submitter
- CCDC170 p.Ser357Arg Uncertain significance Single submitter
- CCDC170 p.Ser606Ala Uncertain significance Single submitter
- CCDC170 p.Thr117Ala Uncertain significance Single submitter
- CCDC170 p.Thr566Ser Uncertain significance Single submitter
- CCDC170 p.Val476Ile Uncertain significance Single submitter
- CCDC170 p.Val656Leu Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- CCDC170 p.Ala331Val Uncertain significance Single submitter
- CCDC170 p.Ala615Asp Benign Single submitter
- CCDC170 p.Arg176Cys Uncertain significance Single submitter
- CCDC170 p.Arg198Gly Uncertain significance Single submitter
- CCDC170 p.Arg201His Uncertain significance Single submitter
- CCDC170 p.Arg358Gln Likely benign Single submitter
- CCDC170 p.Arg364Trp Uncertain significance Single submitter
- CCDC170 p.Arg457Trp Uncertain significance Single submitter
- CCDC170 p.Arg508Trp Uncertain significance Single submitter
- CCDC170 p.Arg553Gly Uncertain significance Single submitter
- CCDC170 p.Arg587Gly Uncertain significance Single submitter
- CCDC170 p.Asn144Ile Uncertain significance Single submitter
- CCDC170 p.Cys150Arg Uncertain significance Single submitter
- CCDC170 p.Gln148His Uncertain significance Single submitter
- CCDC170 p.Gln285Arg Uncertain significance Single submitter
- CCDC170 p.Gln379Leu Uncertain significance Single submitter
- CCDC170 p.Glu109Val Uncertain significance Single submitter
- CCDC170 p.Glu252Gly Uncertain significance Single submitter
- CCDC170 p.Glu273Gly Uncertain significance Single submitter
- CCDC170 p.Glu345Lys Conflicting Single submitter
- CCDC170 p.Glu516Asp Uncertain significance Single submitter
- CCDC170 p.Glu620Asp Uncertain significance Single submitter
- CCDC170 p.Glu62Lys Uncertain significance Single submitter
- CCDC170 p.Glu655Lys Uncertain significance Single submitter
- CCDC170 p.His613Tyr Uncertain significance Single submitter
- CCDC170 p.Ile676Phe Uncertain significance Single submitter
- CCDC170 p.Leu115Pro Uncertain significance Single submitter
- CCDC170 p.Leu297Pro Uncertain significance Single submitter
- CCDC170 p.Leu404Pro Uncertain significance Single submitter
- CCDC170 p.Leu411Gln Uncertain significance Single submitter
- CCDC170 p.Leu458Pro Uncertain significance Single submitter
- CCDC170 p.Leu559Phe Uncertain significance Single submitter
- CCDC170 p.Leu66His Uncertain significance Single submitter
- CCDC170 p.Leu98Phe Uncertain significance Single submitter
- CCDC170 p.Lys329Asn Uncertain significance Single submitter
- CCDC170 p.Lys638Ile Uncertain significance Single submitter
- CCDC170 p.Lys88Met Uncertain significance Single submitter
- CCDC170 p.Met355Thr Uncertain significance Single submitter
- CCDC170 p.Ser312Cys Uncertain significance Single submitter
- CCDC170 p.Ser384Phe Uncertain significance Single submitter
- CCDC170 p.Thr231Met Uncertain significance Single submitter
- CCDC170 p.Thr31Ala Uncertain significance Single submitter
- CCDC170 p.Thr522Met Uncertain significance Single submitter
- CCDC170 p.Thr551Met Uncertain significance Single submitter
- CCDC170 p.Thr692Ile Uncertain significance Single submitter
- CCDC170 p.Val366Ala Uncertain significance Single submitter
All CCDC170 variants
Conflicting classifications of pathogenicity 2
- p.Glu345Lys Single submitter ⚠
- p.Val604Ile Single submitter CCDC170-related condition ⚠
Benign 4
- c.*566C>T Single submitter
- p.Ala615Asp Single submitter ⚠
- p.Arg393Lys Single submitter
- p.Asn479Lys Single submitter
Likely benign 2
- p.Arg358Gln Single submitter ⚠
- p.Thr692= Single submitter
Uncertain significance 96
- p.Ala17Glu Single submitter ⚠
- p.Ala17Val Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Ala315Glu Single submitter ⚠
- p.Ala331Val Single submitter ⚠
- p.Ala694Asp Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg198Gly Single submitter ⚠
- p.Arg201His Single submitter ⚠
- p.Arg201Ser Single submitter ⚠
- p.Arg32Gly Single submitter ⚠
- p.Arg32Pro Single submitter ⚠
- p.Arg364Trp Single submitter ⚠
- p.Arg422Gln Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg457Trp Single submitter ⚠
- p.Arg470Gly Single submitter ⚠
- p.Arg508Gln Single submitter ⚠
- p.Arg508Trp Single submitter ⚠
- p.Arg521Cys Single submitter ⚠
- p.Arg553Gly Single submitter ⚠
- p.Arg587Gly Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Asn144Ile Single submitter ⚠
- p.Asn399Ser Single submitter ⚠
- p.Asn567Ser Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp23Gly Single submitter ⚠
- p.Asp356Tyr Single submitter ⚠
- p.Asp4Glu Single submitter ⚠
- p.Asp565Asn Single submitter ⚠
- p.Asp565His Single submitter ⚠
- p.Asp65Ala Single submitter ⚠
- p.Cys150Arg Single submitter ⚠
- p.Cys249Tyr Single submitter ⚠
- p.Cys552Phe Single submitter ⚠
- p.Gln148His Single submitter ⚠
- p.Gln285Arg Single submitter ⚠
- p.Gln285Glu Single submitter ⚠
- p.Gln379Leu Single submitter ⚠
- p.Gln388Arg Single submitter ⚠
- p.Glu109Val Single submitter ⚠
- p.Glu20Gly Single submitter ⚠
- p.Glu252Gly Single submitter ⚠
- p.Glu273Gly Single submitter ⚠
- p.Glu498Gln Single submitter ⚠
- p.Glu516Asp Single submitter ⚠
- p.Glu614Lys Single submitter ⚠
- p.Glu620Asp Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Glu655Lys Single submitter ⚠
- p.Glu704Lys Single submitter ⚠
- p.Glu79Ala Single submitter ⚠
- p.His410Gln Single submitter ⚠
- p.His532Tyr Single submitter ⚠
- p.His613Tyr Single submitter ⚠
- p.His710Leu Single submitter ⚠
- p.Ile626Thr Single submitter ⚠
- p.Ile676Phe Single submitter ⚠
- p.Leu115Pro Single submitter ⚠
- p.Leu297Pro Single submitter ⚠
- p.Leu404Pro Single submitter ⚠
- p.Leu411Gln Single submitter ⚠
- p.Leu458Pro Single submitter ⚠
- p.Leu559Phe Single submitter ⚠
- p.Leu608Pro Single submitter ⚠
- p.Leu66His Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys158Glu Single submitter ⚠
- p.Lys329Asn Single submitter ⚠
- p.Lys510Arg Single submitter ⚠
- p.Lys638Ile Single submitter ⚠
- p.Lys69Gln Single submitter ⚠
- p.Lys88Met Single submitter ⚠
- p.Met355Thr Single submitter ⚠
- p.Phe277Ser Single submitter ⚠
- p.Phe435Leu Single submitter ⚠
- p.Ser262Arg Single submitter ⚠
- p.Ser312Cys Single submitter ⚠
- p.Ser325Leu Single submitter ⚠
- p.Ser357Arg Single submitter ⚠
- p.Ser384Phe Single submitter ⚠
- p.Ser606Ala Single submitter ⚠
- p.Thr117Ala Single submitter ⚠
- p.Thr231Met Single submitter ⚠
- p.Thr31Ala Single submitter ⚠
- p.Thr522Met Single submitter ⚠
- p.Thr551Met Single submitter ⚠
- p.Thr566Ser Single submitter ⚠
- p.Thr692Ile Single submitter ⚠
- p.Val366Ala Single submitter ⚠
- p.Val476Ile Single submitter ⚠
- p.Val656Leu Single submitter ⚠
- c.1710+1144T>G No assertion criteria estrogen resistance syndrome
- c.*68A>C No assertion criteria estrogen resistance syndrome
- c.*978A>G No assertion criteria estrogen resistance syndrome