CCDC171 — 266 ClinVar variants

All ClinVar germline CCDC171 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 247 flagged for review →

3 Benign · 10 Likely benign · 253 Uncertain significance

Full CCDC171 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 247

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 225

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 225

Predictors split 22

The independent predictors disagree with each other — read with care.

All CCDC171 variants

Benign 3

p.Ala807= Multiple submitters
p.Lys477Gln Multiple submitters
p.Val74Ala Multiple submitters

Likely benign 10

p.Ala478Thr Single submitter
p.Arg164Gln Single submitter
p.Arg622Ser Single submitter
p.Glu165= Single submitter
p.Glu498Asp Single submitter
p.Glu780Asp Single submitter
p.Ser65Asn Single submitter
p.Thr1153Met Single submitter
p.Thr229Ser Single submitter
p.Thr966Met Single submitter

Uncertain significance 253

p.Ala102Val Single submitter ⚠
p.Ala1060Pro Single submitter ⚠
p.Ala1060Thr Single submitter ⚠
p.Ala1094Ser Single submitter ⚠
p.Ala1132Ser Single submitter ⚠
p.Ala1201Gly Single submitter ⚠
p.Ala1213Glu Single submitter ⚠
p.Ala1232Glu Single submitter ⚠
p.Ala125Val Single submitter ⚠
p.Ala1266Val Single submitter ⚠
p.Ala1283Asp Single submitter ⚠
p.Ala1316Pro Single submitter ⚠
p.Ala18Pro Single submitter ⚠
p.Ala202Gly Single submitter ⚠
p.Ala293Ser Single submitter ⚠
p.Ala293Thr Single submitter ⚠
p.Ala320Val Single submitter ⚠
p.Ala327Val Single submitter ⚠
p.Ala406Ser Single submitter ⚠
p.Ala522Thr Single submitter ⚠
p.Ala543Gly Single submitter ⚠
p.Ala545Thr Single submitter ⚠
p.Ala61Ser Single submitter ⚠
p.Ala747Thr Single submitter ⚠
p.Ala863Val Single submitter ⚠
p.Ala905Gly Single submitter
p.Ala91Asp Single submitter ⚠
p.Arg100Trp Single submitter ⚠
p.Arg1048Gln Single submitter
p.Arg1106Cys Single submitter
p.Arg1106His Single submitter ⚠
p.Arg1110Ser Single submitter ⚠
p.Arg1120Cys Single submitter ⚠
p.Arg1121Gln Single submitter ⚠
p.Arg1134Leu Single submitter ⚠
p.Arg1158Lys Single submitter ⚠
p.Arg1228Gln Single submitter ⚠
p.Arg1255Gln Single submitter ⚠
p.Arg146Lys Single submitter ⚠
p.Arg189Trp Single submitter ⚠
p.Arg199Lys Single submitter ⚠
p.Arg268Cys Single submitter ⚠
p.Arg457Ser Single submitter ⚠
p.Arg460His Single submitter ⚠
p.Arg520Gln Single submitter ⚠
p.Arg799Cys Single submitter ⚠
p.Arg799His Single submitter ⚠
p.Arg960Cys Single submitter ⚠
p.Arg960His Single submitter ⚠
p.Arg990Gly Single submitter ⚠
p.Arg991Cys Single submitter ⚠
p.Arg994Leu Single submitter ⚠
p.Asn1022Ser Single submitter ⚠
p.Asn1044Ser Single submitter ⚠
p.Asn1125Ser Single submitter ⚠
p.Asn1259Asp Single submitter ⚠
p.Asn1259His Single submitter ⚠
p.Asn349Lys Single submitter ⚠
p.Asn467Asp Single submitter ⚠
p.Asn57Thr Single submitter ⚠
p.Asn615Ser Single submitter ⚠
p.Asn618Asp Single submitter ⚠
p.Asn692His Single submitter ⚠
p.Asn760Ser Single submitter ⚠
p.Asn760Tyr Single submitter ⚠
p.Asp1159Gly Single submitter
p.Asp1286Glu Single submitter ⚠
p.Asp156Gly Single submitter ⚠
p.Asp156His Single submitter ⚠
p.Asp21His Single submitter ⚠
p.Asp250Val Single submitter ⚠
p.Asp444His Single submitter ⚠
p.Asp483Gly Single submitter ⚠
p.Asp613His Single submitter ⚠
p.Asp846Gly Single submitter ⚠
p.Asp846His Single submitter ⚠
p.Asp871Tyr Single submitter ⚠
p.Asp87Val Single submitter ⚠
p.Asp937Gly Single submitter ⚠
p.Asp937Tyr Single submitter ⚠
p.Cys1039Phe Single submitter ⚠
p.Cys117Phe Single submitter ⚠
p.Cys162Ser Single submitter ⚠
p.Cys396Tyr Single submitter ⚠
p.Cys479Arg Single submitter ⚠
p.Cys581Phe Single submitter ⚠
p.Cys600Tyr Single submitter
p.Gln1015His Single submitter ⚠
p.Gln1026Arg Single submitter ⚠
p.Gln1082His Single submitter ⚠
p.Gln1103Pro Single submitter ⚠
p.Gln188Glu Single submitter ⚠
p.Gln188Pro Single submitter ⚠
p.Gln209Glu Single submitter ⚠
p.Gln212His Single submitter ⚠
p.Gln227Lys Single submitter ⚠
p.Gln24Glu Single submitter ⚠
p.Gln322Glu Single submitter ⚠
p.Gln390His Single submitter ⚠
p.Gln410Glu Single submitter ⚠
p.Gln670Arg Single submitter ⚠
p.Gln758Glu Single submitter ⚠
p.Gln845Glu Single submitter ⚠
p.Gln884Arg Single submitter ⚠
p.Gln941Arg Single submitter ⚠
p.Gln941His Single submitter ⚠
p.Glu1058Gln Single submitter ⚠
p.Glu1065Lys Single submitter ⚠
p.Glu1077Lys Single submitter ⚠
p.Glu1093Asp Single submitter ⚠
p.Glu1093Lys Single submitter ⚠
p.Glu1188Gln Single submitter ⚠
p.Glu149Gln Single submitter ⚠
p.Glu172Asp Single submitter ⚠
p.Glu195Gln Single submitter ⚠
p.Glu211Lys Single submitter ⚠
p.Glu272Gly Single submitter ⚠
p.Glu340Lys Single submitter ⚠
p.Glu376Lys Single submitter ⚠
p.Glu51Asp Single submitter ⚠
p.Glu551Lys Single submitter ⚠
p.Glu59Lys Single submitter ⚠
p.Glu625Gln Single submitter ⚠
p.Glu637Lys Single submitter ⚠
p.Glu687Lys Single submitter ⚠
p.Glu690Gly Single submitter ⚠
p.Glu73Val Single submitter ⚠
p.Glu996Asp Single submitter ⚠
p.Gly1276Arg Single submitter ⚠
p.Gly836Ser Single submitter ⚠
p.Gly888Ala Single submitter ⚠
p.Gly903Asp Single submitter ⚠
p.Gly96Ala Single submitter ⚠
p.Gly98Arg Single submitter ⚠
p.His110Arg Single submitter ⚠
p.His1111Leu Single submitter ⚠
p.His1155Tyr Single submitter ⚠
p.His1302Arg Single submitter ⚠
p.His235Arg Single submitter ⚠
p.His536Arg Single submitter ⚠
p.His536Pro Single submitter ⚠
p.His560Arg Single submitter ⚠
p.His623Gln Single submitter ⚠
p.His712Leu Single submitter ⚠
p.His853Tyr Single submitter ⚠
p.His899Arg Single submitter ⚠
p.His899Leu Single submitter ⚠
p.His926Tyr Single submitter ⚠
p.His984Tyr Single submitter ⚠
p.Ile159Ser Single submitter ⚠
p.Ile611Met Single submitter ⚠
p.Ile621Leu Single submitter ⚠
p.Ile699Val Single submitter ⚠
p.Ile800Met Single submitter ⚠
p.Ile896Thr Single submitter ⚠
p.Ile902Leu Single submitter ⚠
p.Ile923Thr Single submitter ⚠
p.Leu1133Phe Single submitter ⚠
p.Leu1163Val Single submitter ⚠
p.Leu116Phe Single submitter ⚠
p.Leu1175Pro Single submitter ⚠
p.Leu152Val Single submitter ⚠
p.Leu176Pro Single submitter ⚠
p.Leu259Val Single submitter ⚠
p.Leu26Pro Single submitter ⚠
p.Leu38Phe Single submitter ⚠
p.Leu428Val Single submitter ⚠
p.Leu527Ile Single submitter ⚠
p.Leu555Phe Single submitter ⚠
p.Leu669Gln Single submitter ⚠
p.Leu728Arg Single submitter ⚠
p.Leu741Val Single submitter ⚠
p.Leu797Met Single submitter ⚠
p.Leu814Pro Single submitter ⚠
p.Leu867Pro Single submitter ⚠
p.Leu867Val Single submitter ⚠
p.Leu977Val Single submitter ⚠
p.Leu983Gln Single submitter ⚠
p.Lys140Arg Single submitter ⚠
p.Lys186Arg Single submitter ⚠
p.Lys186Glu Single submitter ⚠
p.Lys237Glu Single submitter ⚠
p.Lys23Glu Single submitter ⚠
p.Lys240Gln Single submitter ⚠
p.Lys370Thr Single submitter ⚠
p.Lys379Asn Single submitter ⚠
p.Lys40Gln Single submitter ⚠
p.Lys422Glu Single submitter ⚠
p.Lys468Met Single submitter ⚠
p.Lys46Arg Single submitter ⚠
p.Lys691Glu Single submitter ⚠
p.Lys76Met Single submitter ⚠
p.Lys792Arg Single submitter ⚠
p.Lys792Thr Single submitter ⚠
p.Lys803Arg Single submitter ⚠
p.Lys849Thr Single submitter ⚠
p.Lys911Asn Single submitter ⚠
p.Lys915Glu Single submitter ⚠
p.Lys974Asn Single submitter ⚠
p.Met1019Ile Single submitter ⚠
p.Met1054Lys Single submitter ⚠
p.Met1135Val Single submitter ⚠
p.Met1147Leu Single submitter ⚠
p.Met1202Val Single submitter ⚠
p.Met1207Val Single submitter ⚠
p.Met1224Ile Single submitter ⚠
p.Met1314Val Single submitter ⚠
p.Met590Arg Single submitter ⚠
p.Met725Ile Single submitter ⚠
p.Met789Val Single submitter ⚠
p.Met837Val Single submitter ⚠
p.Phe261Cys Single submitter ⚠
p.Pro1178Arg Single submitter ⚠
p.Pro1194Ser Single submitter ⚠
p.Pro1321Arg Single submitter ⚠
p.Pro1321Thr Single submitter ⚠
p.Pro740Leu Single submitter ⚠
p.Pro851Leu Single submitter ⚠
p.Ser1090Arg Single submitter ⚠
p.Ser1092Phe Single submitter ⚠
p.Ser1131Gly Single submitter ⚠
p.Ser1162Leu Single submitter ⚠
p.Ser19Leu Single submitter ⚠
p.Ser395Arg Single submitter ⚠
p.Ser450Thr Single submitter ⚠
p.Ser548Cys Single submitter ⚠
p.Ser62Gly Single submitter ⚠
p.Ser6Ala Single submitter ⚠
p.Ser711Leu Single submitter ⚠
p.Ser7Gly Single submitter ⚠
p.Ser823Phe Single submitter ⚠
p.Ser869Gly Single submitter ⚠
p.Ser908Cys Single submitter ⚠
p.Ser928Arg Single submitter ⚠
p.Ser930Gly Single submitter ⚠
p.Thr1295Ile Single submitter ⚠
p.Thr263Ile Single submitter ⚠
p.Thr485Pro Single submitter ⚠
p.Thr980Ala Single submitter ⚠
p.Tyr391Cys Single submitter ⚠
p.Tyr391His Single submitter ⚠
p.Tyr63Phe Single submitter ⚠
p.Tyr957Cys Single submitter ⚠
p.Val381Ala Single submitter ⚠
p.Val381Ile Single submitter ⚠
p.Val381Leu Single submitter ⚠
p.Val529Met Single submitter ⚠
p.Val534Met Single submitter ⚠
p.Val759Ile Single submitter ⚠
p.Val759Phe Single submitter ⚠
p.Val779Ala Single submitter ⚠
p.Val886Ile Single submitter ⚠
p.Arg802Trp No assertion criteria prostate cancer