CCDC175 — 95 ClinVar variants
All ClinVar germline CCDC175 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
7 Likely benign · 88 Uncertain significance
Full CCDC175 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC175 p.Ala124Thr Uncertain significance Single submitter
- CCDC175 p.Ala219Val Uncertain significance Single submitter
- CCDC175 p.Ala316Val Uncertain significance Single submitter
- CCDC175 p.Ala429Ser Uncertain significance Single submitter
- CCDC175 p.Arg122Gln Uncertain significance Single submitter
- CCDC175 p.Arg354His Uncertain significance Single submitter
- CCDC175 p.Arg468Cys Uncertain significance Single submitter
- CCDC175 p.Arg468His Uncertain significance Single submitter
- CCDC175 p.Arg625Gln Uncertain significance Single submitter
- CCDC175 p.Asn337Ser Uncertain significance Single submitter
- CCDC175 p.Asn729Asp Uncertain significance Single submitter
- CCDC175 p.Asp323Gly Uncertain significance Single submitter
- CCDC175 p.Asp330Asn Uncertain significance Single submitter
- CCDC175 p.Asp654Ala Uncertain significance Single submitter
- CCDC175 p.Asp766Glu Uncertain significance Single submitter
- CCDC175 p.Asp90Asn Uncertain significance Single submitter
- CCDC175 p.Cys319Tyr Uncertain significance Single submitter
- CCDC175 p.Gln266Arg Uncertain significance Single submitter
- CCDC175 p.Glu362Asp Uncertain significance Single submitter
- CCDC175 p.Glu522Lys Uncertain significance Single submitter
- CCDC175 p.Glu536Lys Uncertain significance Single submitter
- CCDC175 p.Glu722Gln Uncertain significance Single submitter
- CCDC175 p.Gly645Arg Uncertain significance Single submitter
- CCDC175 p.Gly680Glu Uncertain significance Single submitter
- CCDC175 p.Gly680Val Uncertain significance Single submitter
- CCDC175 p.His294Arg Uncertain significance Single submitter
- CCDC175 p.His466Arg Uncertain significance Single submitter
- CCDC175 p.Ile113Thr Uncertain significance Single submitter
- CCDC175 p.Ile290Thr Uncertain significance Single submitter
- CCDC175 p.Ile331Val Uncertain significance Single submitter
- CCDC175 p.Ile343Val Uncertain significance Single submitter
- CCDC175 p.Ile413Val Uncertain significance Single submitter
- CCDC175 p.Ile438Val Uncertain significance Single submitter
- CCDC175 p.Ile696Val Uncertain significance Single submitter
- CCDC175 p.Ile774Val Uncertain significance Single submitter
- CCDC175 p.Ile89Val Uncertain significance Single submitter
- CCDC175 p.Leu767Phe Uncertain significance Single submitter
- CCDC175 p.Lys358Glu Uncertain significance Single submitter
- CCDC175 p.Lys431Glu Uncertain significance Single submitter
- CCDC175 p.Lys520Glu Uncertain significance Single submitter
- CCDC175 p.Lys740Thr Uncertain significance Single submitter
- CCDC175 p.Met185Thr Uncertain significance Single submitter
- CCDC175 p.Met459Leu Uncertain significance Single submitter
- CCDC175 p.Met532Ile Uncertain significance Single submitter
- CCDC175 p.Met741Arg Uncertain significance Single submitter
- CCDC175 p.Pro781Gln Uncertain significance Single submitter
- CCDC175 p.Ser112Asn Uncertain significance Single submitter
- CCDC175 p.Ser35Ala Uncertain significance Single submitter
- CCDC175 p.Ser442Arg Uncertain significance Single submitter
- CCDC175 p.Ser449Thr Uncertain significance Single submitter
- CCDC175 p.Ser583Arg Uncertain significance Single submitter
- CCDC175 p.Thr142Ile Uncertain significance Single submitter
- CCDC175 p.Thr157Arg Uncertain significance Single submitter
- CCDC175 p.Thr517Ala Uncertain significance Single submitter
- CCDC175 p.Thr776Arg Uncertain significance Single submitter
- CCDC175 p.Trp747Gly Uncertain significance Single submitter
- CCDC175 p.Tyr256His Uncertain significance Single submitter
- CCDC175 p.Tyr647Cys Uncertain significance Single submitter
- CCDC175 p.Val304Ala Uncertain significance Single submitter
- CCDC175 p.Val41Ala Uncertain significance Single submitter
- CCDC175 p.Val713Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CCDC175 p.Ala228Pro Uncertain significance Single submitter
- CCDC175 p.Ala353Pro Uncertain significance Single submitter
- CCDC175 p.Arg206Gly Uncertain significance Single submitter
- CCDC175 p.Arg354Pro Uncertain significance Single submitter
- CCDC175 p.Arg693Pro Uncertain significance Single submitter
- CCDC175 p.Cys120Arg Uncertain significance Single submitter
- CCDC175 p.Gln217His Uncertain significance Single submitter
- CCDC175 p.Gln549His Uncertain significance Single submitter
- CCDC175 p.Gln566His Likely benign Single submitter
- CCDC175 p.Gln570Pro Uncertain significance Single submitter
- CCDC175 p.Glu131Gly Uncertain significance Single submitter
- CCDC175 p.Glu207Asp Uncertain significance Single submitter
- CCDC175 p.Glu218Asp Uncertain significance Single submitter
- CCDC175 p.Glu236Gly Uncertain significance Single submitter
- CCDC175 p.Glu261Gln Uncertain significance Single submitter
- CCDC175 p.Glu391Asp Uncertain significance Single submitter
- CCDC175 p.Glu391Lys Uncertain significance Single submitter
- CCDC175 p.Glu403Asp Uncertain significance Single submitter
- CCDC175 p.Ile241Val Uncertain significance Single submitter
- CCDC175 p.Ile297Met Uncertain significance Single submitter
- CCDC175 p.Leu237Met Uncertain significance Single submitter
- CCDC175 p.Leu396Pro Uncertain significance Single submitter
- CCDC175 p.Leu406Arg Uncertain significance Single submitter
- CCDC175 p.Leu582Arg Uncertain significance Single submitter
- CCDC175 p.Leu663Ile Uncertain significance Single submitter
- CCDC175 p.Lys150Arg Uncertain significance Single submitter
- CCDC175 p.Lys380Thr Uncertain significance Single submitter
- CCDC175 p.Lys630Ile Uncertain significance Single submitter
All CCDC175 variants
Likely benign 7
- p.Arg176Lys Single submitter
- p.Arg756His Single submitter
- p.Asp654Glu Single submitter
- p.Gln485Glu Single submitter
- p.Gln566His Single submitter ⚠
- p.Lys158Glu Single submitter
- p.Ser612Asn Single submitter
Uncertain significance 88
- p.Ala124Thr Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala228Pro Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala353Pro Single submitter ⚠
- p.Ala429Ser Single submitter ⚠
- p.Arg122Gln Single submitter ⚠
- p.Arg206Gly Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg354Pro Single submitter ⚠
- p.Arg468Cys Single submitter ⚠
- p.Arg468His Single submitter ⚠
- p.Arg625Gln Single submitter ⚠
- p.Arg693Pro Single submitter ⚠
- p.Asn337Ser Single submitter ⚠
- p.Asn729Asp Single submitter ⚠
- p.Asp323Gly Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Asp654Ala Single submitter ⚠
- p.Asp766Glu Single submitter ⚠
- p.Asp90Asn Single submitter ⚠
- p.Cys120Arg Single submitter ⚠
- p.Cys319Tyr Single submitter ⚠
- p.Gln217His Single submitter ⚠
- p.Gln266Arg Single submitter ⚠
- p.Gln549His Single submitter ⚠
- p.Gln570Pro Single submitter ⚠
- p.Glu131Gly Single submitter ⚠
- p.Glu207Asp Single submitter ⚠
- p.Glu218Asp Single submitter ⚠
- p.Glu236Gly Single submitter ⚠
- p.Glu261Gln Single submitter ⚠
- p.Glu362Asp Single submitter ⚠
- p.Glu391Asp Single submitter ⚠
- p.Glu391Lys Single submitter ⚠
- p.Glu403Asp Single submitter ⚠
- p.Glu522Lys Single submitter ⚠
- p.Glu536Lys Single submitter ⚠
- p.Glu722Gln Single submitter ⚠
- p.Gly645Arg Single submitter ⚠
- p.Gly680Glu Single submitter ⚠
- p.Gly680Val Single submitter ⚠
- p.His294Arg Single submitter ⚠
- p.His466Arg Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile241Val Single submitter ⚠
- p.Ile290Thr Single submitter ⚠
- p.Ile297Met Single submitter ⚠
- p.Ile331Val Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Ile438Val Single submitter ⚠
- p.Ile696Val Single submitter ⚠
- p.Ile774Val Single submitter ⚠
- p.Ile89Val Single submitter ⚠
- p.Leu237Met Single submitter ⚠
- p.Leu396Pro Single submitter ⚠
- p.Leu406Arg Single submitter ⚠
- p.Leu582Arg Single submitter ⚠
- p.Leu663Ile Single submitter ⚠
- p.Leu767Phe Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys358Glu Single submitter ⚠
- p.Lys380Thr Single submitter ⚠
- p.Lys431Glu Single submitter ⚠
- p.Lys520Glu Single submitter ⚠
- p.Lys630Ile Single submitter ⚠
- p.Lys740Thr Single submitter ⚠
- p.Met185Thr Single submitter ⚠
- p.Met459Leu Single submitter ⚠
- p.Met532Ile Single submitter ⚠
- p.Met741Arg Single submitter ⚠
- p.Pro781Gln Single submitter ⚠
- p.Ser112Asn Single submitter ⚠
- p.Ser35Ala Single submitter ⚠
- p.Ser442Arg Single submitter ⚠
- p.Ser449Thr Single submitter ⚠
- p.Ser583Arg Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Thr157Arg Single submitter ⚠
- p.Thr517Ala Single submitter ⚠
- p.Thr776Arg Single submitter ⚠
- p.Trp747Gly Single submitter ⚠
- p.Tyr256His Single submitter ⚠
- p.Tyr647Cys Single submitter ⚠
- p.Val304Ala Single submitter ⚠
- p.Val41Ala Single submitter ⚠
- p.Val713Ile Single submitter ⚠