CCDC178 — 127 ClinVar variants
All ClinVar germline CCDC178 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 112 flagged for review →
16 Likely benign · 111 Uncertain significance
Full CCDC178 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 112
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC178 p.Lys515Arg Uncertain significance Multiple submitters
- CCDC178 p.Ala216Thr Uncertain significance Single submitter
- CCDC178 p.Ala339Asp Uncertain significance Single submitter
- CCDC178 p.Ala339Thr Uncertain significance Single submitter
- CCDC178 p.Ala375Thr Uncertain significance Single submitter
- CCDC178 p.Ala563Thr Uncertain significance Single submitter
- CCDC178 p.Ala574Glu Uncertain significance Single submitter
- CCDC178 p.Ala666Thr Uncertain significance Single submitter
- CCDC178 p.Arg504His Uncertain significance Single submitter
- CCDC178 p.Arg528Thr Uncertain significance Single submitter
- CCDC178 p.Arg566Gln Uncertain significance Single submitter
- CCDC178 p.Arg573Thr Uncertain significance Single submitter
- CCDC178 p.Arg647Cys Uncertain significance Single submitter
- CCDC178 p.Arg647His Uncertain significance Single submitter
- CCDC178 p.Arg83His Uncertain significance Single submitter
- CCDC178 p.Asn18Ser Uncertain significance Single submitter
- CCDC178 p.Asn468Ser Uncertain significance Single submitter
- CCDC178 p.Asn672Ser Uncertain significance Single submitter
- CCDC178 p.Asn776Ser Uncertain significance Single submitter
- CCDC178 p.Asp227Glu Uncertain significance Single submitter
- CCDC178 p.Asp601Gly Uncertain significance Single submitter
- CCDC178 p.Asp728Asn Uncertain significance Single submitter
- CCDC178 p.Asp728Val Uncertain significance Single submitter
- CCDC178 p.Asp866Asn Uncertain significance Single submitter
- CCDC178 p.Gln16Lys Uncertain significance Single submitter
- CCDC178 p.Gln218Lys Uncertain significance Single submitter
- CCDC178 p.Gln321Glu Uncertain significance Single submitter
- CCDC178 p.Gln820Arg Uncertain significance Single submitter
- CCDC178 p.Glu25Lys Uncertain significance Single submitter
- CCDC178 p.Glu310Lys Uncertain significance Single submitter
- CCDC178 p.Glu478Asp Uncertain significance Single submitter
- CCDC178 p.Glu525Lys Uncertain significance Single submitter
- CCDC178 p.Gly270Ala Uncertain significance Single submitter
- CCDC178 p.Gly532Cys Uncertain significance Single submitter
- CCDC178 p.Gly74Asp Uncertain significance Single submitter
- CCDC178 p.His221Leu Uncertain significance Single submitter
- CCDC178 p.His705Arg Uncertain significance Single submitter
- CCDC178 p.Ile430Val Uncertain significance Single submitter
- CCDC178 p.Ile442Val Uncertain significance Single submitter
- CCDC178 p.Ile458Thr Uncertain significance Single submitter
- CCDC178 p.Ile486Val Uncertain significance Single submitter
- CCDC178 p.Ile597Val Uncertain significance Single submitter
- CCDC178 p.Ile851Val Uncertain significance Single submitter
- CCDC178 p.Leu629Ile Uncertain significance Single submitter
- CCDC178 p.Lys209Gln Uncertain significance Single submitter
- CCDC178 p.Lys425Arg Uncertain significance Single submitter
- CCDC178 p.Lys473Glu Uncertain significance Single submitter
- CCDC178 p.Lys624Glu Uncertain significance Single submitter
- CCDC178 p.Lys626Asn Uncertain significance Single submitter
- CCDC178 p.Lys632Asn Uncertain significance Single submitter
- CCDC178 p.Lys772Arg Uncertain significance Single submitter
- CCDC178 p.Lys774Gln Uncertain significance Single submitter
- CCDC178 p.Lys98Arg Uncertain significance Single submitter
- CCDC178 p.Met295Thr Uncertain significance Single submitter
- CCDC178 p.Met519Ile Uncertain significance Single submitter
- CCDC178 p.Met549Val Uncertain significance Single submitter
- CCDC178 p.Met821Val Uncertain significance Single submitter
- CCDC178 p.Pro214Ser Uncertain significance Single submitter
- CCDC178 p.Pro586Ser Uncertain significance Single submitter
- CCDC178 p.Ser388Thr Uncertain significance Single submitter
- CCDC178 p.Ser57Asn Uncertain significance Single submitter
- CCDC178 p.Ser645Asn Uncertain significance Single submitter
- CCDC178 p.Ser684Arg Uncertain significance Single submitter
- CCDC178 p.Ser684Ile Uncertain significance Single submitter
- CCDC178 p.Thr140Ser Uncertain significance Single submitter
- CCDC178 p.Thr427Ile Uncertain significance Single submitter
- CCDC178 p.Thr643Ser Uncertain significance Single submitter
- CCDC178 p.Thr657Ser Uncertain significance Single submitter
- CCDC178 p.Thr661Ser Uncertain significance Single submitter
- CCDC178 p.Thr68Ala Uncertain significance Single submitter
- CCDC178 p.Thr859Ala Uncertain significance Single submitter
- CCDC178 p.Trp405Cys Uncertain significance Single submitter
- CCDC178 p.Tyr556Cys Uncertain significance Single submitter
- CCDC178 p.Tyr781Cys Uncertain significance Single submitter
- CCDC178 p.Val139Glu Uncertain significance Single submitter
- CCDC178 p.Val358Leu Uncertain significance Single submitter
- CCDC178 p.Val361Ile Uncertain significance Single submitter
- CCDC178 p.Val71Leu Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- CCDC178 p.Ala261Gly Uncertain significance Single submitter
- CCDC178 p.Arg730Thr Uncertain significance Single submitter
- CCDC178 p.Arg758His Uncertain significance Single submitter
- CCDC178 p.Asn240Asp Uncertain significance Single submitter
- CCDC178 p.Asp459Gly Uncertain significance Single submitter
- CCDC178 p.Asp459His Uncertain significance Single submitter
- CCDC178 p.Asp492Gly Uncertain significance Single submitter
- CCDC178 p.Gln827His Uncertain significance Single submitter
- CCDC178 p.Glu371Gly Uncertain significance Single submitter
- CCDC178 p.Glu680Gly Uncertain significance Single submitter
- CCDC178 p.Ile202Thr Uncertain significance Single submitter
- CCDC178 p.Ile263Val Uncertain significance Single submitter
- CCDC178 p.Ile330Phe Uncertain significance Single submitter
- CCDC178 p.Ile337Thr Uncertain significance Single submitter
- CCDC178 p.Ile344Val Uncertain significance Single submitter
- CCDC178 p.Ile460Val Uncertain significance Single submitter
- CCDC178 p.Leu386Ser Uncertain significance Single submitter
- CCDC178 p.Leu456His Uncertain significance Single submitter
- CCDC178 p.Leu456Phe Uncertain significance Single submitter
- CCDC178 p.Leu537Arg Uncertain significance Single submitter
- CCDC178 p.Leu569His Uncertain significance Single submitter
- CCDC178 p.Leu600His Uncertain significance Single submitter
- CCDC178 p.Lys554Thr Uncertain significance Single submitter
- CCDC178 p.Lys667Ile Uncertain significance Single submitter
- CCDC178 p.Lys678Glu Uncertain significance Single submitter
- CCDC178 p.Lys783Asn Uncertain significance Single submitter
- CCDC178 p.Phe812Leu Uncertain significance Single submitter
- CCDC178 p.Ser355Phe Uncertain significance Single submitter
- CCDC178 p.Ser648Pro Uncertain significance Single submitter
- CCDC178 p.Thr22Ala Uncertain significance Single submitter
- CCDC178 p.Thr373Pro Uncertain significance Single submitter
- CCDC178 p.Thr450Met Likely benign Single submitter
- CCDC178 p.Trp208Arg Uncertain significance Single submitter
- CCDC178 p.Tyr763Cys Uncertain significance Single submitter
All CCDC178 variants
Likely benign 16
- p.Arg116= Single submitter
- p.Arg316Lys Single submitter
- p.Arg758Leu Single submitter
- p.Asn825Lys Single submitter
- p.Asp183Glu Single submitter
- p.Glu680Lys Single submitter
- p.Gly149Glu Single submitter
- p.Gly40Asp Single submitter
- p.Ile791Val Single submitter
- p.Lys529= Single submitter
- p.Ser388Ala Single submitter
- p.Thr450Met Single submitter ⚠
- p.Thr657Ala Single submitter
- p.Thr688Ile Single submitter
- p.Thr708Ala Single submitter
- p.Val7Ile Single submitter
Uncertain significance 111
- p.Lys515Arg Multiple submitters ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala261Gly Single submitter ⚠
- p.Ala339Asp Single submitter ⚠
- p.Ala339Thr Single submitter ⚠
- p.Ala375Thr Single submitter ⚠
- p.Ala563Thr Single submitter ⚠
- p.Ala574Glu Single submitter ⚠
- p.Ala666Thr Single submitter ⚠
- p.Arg504His Single submitter ⚠
- p.Arg528Thr Single submitter ⚠
- p.Arg566Gln Single submitter ⚠
- p.Arg573Thr Single submitter ⚠
- p.Arg647Cys Single submitter ⚠
- p.Arg647His Single submitter ⚠
- p.Arg730Thr Single submitter ⚠
- p.Arg758His Single submitter ⚠
- p.Arg83His Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn240Asp Single submitter ⚠
- p.Asn468Ser Single submitter ⚠
- p.Asn672Ser Single submitter ⚠
- p.Asn776Ser Single submitter ⚠
- p.Asp227Glu Single submitter ⚠
- p.Asp459Gly Single submitter ⚠
- p.Asp459His Single submitter ⚠
- p.Asp492Gly Single submitter ⚠
- p.Asp601Gly Single submitter ⚠
- p.Asp728Asn Single submitter ⚠
- p.Asp728Val Single submitter ⚠
- p.Asp866Asn Single submitter ⚠
- p.Gln16Lys Single submitter ⚠
- p.Gln218Lys Single submitter ⚠
- p.Gln321Glu Single submitter ⚠
- p.Gln820Arg Single submitter ⚠
- p.Gln827His Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu310Lys Single submitter ⚠
- p.Glu371Gly Single submitter ⚠
- p.Glu478Asp Single submitter ⚠
- p.Glu525Lys Single submitter ⚠
- p.Glu680Gly Single submitter ⚠
- p.Gly270Ala Single submitter ⚠
- p.Gly532Cys Single submitter ⚠
- p.Gly74Asp Single submitter ⚠
- p.His221Leu Single submitter ⚠
- p.His705Arg Single submitter ⚠
- p.Ile202Thr Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Ile330Phe Single submitter ⚠
- p.Ile337Thr Single submitter ⚠
- p.Ile344Val Single submitter ⚠
- p.Ile430Val Single submitter ⚠
- p.Ile442Val Single submitter ⚠
- p.Ile458Thr Single submitter ⚠
- p.Ile460Val Single submitter ⚠
- p.Ile486Val Single submitter ⚠
- p.Ile597Val Single submitter ⚠
- p.Ile851Val Single submitter ⚠
- p.Leu386Ser Single submitter ⚠
- p.Leu456His Single submitter ⚠
- p.Leu456Phe Single submitter ⚠
- p.Leu537Arg Single submitter ⚠
- p.Leu569His Single submitter ⚠
- p.Leu600His Single submitter ⚠
- p.Leu629Ile Single submitter ⚠
- p.Lys209Gln Single submitter ⚠
- p.Lys425Arg Single submitter ⚠
- p.Lys473Glu Single submitter ⚠
- p.Lys554Thr Single submitter ⚠
- p.Lys624Glu Single submitter ⚠
- p.Lys626Asn Single submitter ⚠
- p.Lys632Asn Single submitter ⚠
- p.Lys667Ile Single submitter ⚠
- p.Lys678Glu Single submitter ⚠
- p.Lys772Arg Single submitter ⚠
- p.Lys774Gln Single submitter ⚠
- p.Lys783Asn Single submitter ⚠
- p.Lys98Arg Single submitter ⚠
- p.Met295Thr Single submitter ⚠
- p.Met519Ile Single submitter ⚠
- p.Met549Val Single submitter ⚠
- p.Met821Val Single submitter ⚠
- p.Phe812Leu Single submitter ⚠
- p.Pro214Ser Single submitter ⚠
- p.Pro586Ser Single submitter ⚠
- p.Ser355Phe Single submitter ⚠
- p.Ser388Thr Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Ser645Asn Single submitter ⚠
- p.Ser648Pro Single submitter ⚠
- p.Ser684Arg Single submitter ⚠
- p.Ser684Ile Single submitter ⚠
- p.Thr140Ser Single submitter ⚠
- p.Thr22Ala Single submitter ⚠
- p.Thr373Pro Single submitter ⚠
- p.Thr427Ile Single submitter ⚠
- p.Thr643Ser Single submitter ⚠
- p.Thr657Ser Single submitter ⚠
- p.Thr661Ser Single submitter ⚠
- p.Thr68Ala Single submitter ⚠
- p.Thr859Ala Single submitter ⚠
- p.Trp208Arg Single submitter ⚠
- p.Trp405Cys Single submitter ⚠
- p.Tyr556Cys Single submitter ⚠
- p.Tyr763Cys Single submitter ⚠
- p.Tyr781Cys Single submitter ⚠
- p.Val139Glu Single submitter ⚠
- p.Val358Leu Single submitter ⚠
- p.Val361Ile Single submitter ⚠
- p.Val71Leu Single submitter ⚠