CCDC179 — 10 ClinVar variants
All ClinVar germline CCDC179 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full CCDC179 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC179 p.Cys2Tyr Uncertain significance Single submitter
-
CCDC179 p.Glu9Gln
Uncertain significance
Single submitter
bladder exstrophy-epispadias-cloacal exstrophy complex
- CCDC179 p.Glu9Lys Uncertain significance Single submitter
- CCDC179 p.His41Tyr Uncertain significance Single submitter
- CCDC179 p.Pro10Ser Uncertain significance Single submitter
- CCDC179 p.Pro18Ser Uncertain significance Single submitter
- CCDC179 p.Pro62Arg Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CCDC179 variants
Uncertain significance 10
- p.Arg29Trp Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg47Gly Single submitter ⚠
- p.Cys2Tyr Single submitter ⚠
- p.Glu9Gln Single submitter bladder exstrophy-epispadias-cloacal exstrophy complex ⚠
- p.Glu9Lys Single submitter ⚠
- p.His41Tyr Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro62Arg Single submitter ⚠