CCDC181 — 77 ClinVar variants
All ClinVar germline CCDC181 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
5 Likely benign · 72 Uncertain significance
Full CCDC181 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC181 p.Ala292Thr Uncertain significance Single submitter
- CCDC181 p.Ala41Val Uncertain significance Single submitter
- CCDC181 p.Arg310Gln Uncertain significance Single submitter
- CCDC181 p.Arg416Gln Uncertain significance Single submitter
- CCDC181 p.Arg460Ile Uncertain significance Single submitter
- CCDC181 p.Arg481Gln Uncertain significance Single submitter
- CCDC181 p.Arg503His Uncertain significance Single submitter
- CCDC181 p.Asn178Lys Uncertain significance Single submitter
- CCDC181 p.Asn181Ser Uncertain significance Single submitter
- CCDC181 p.Asn307Ser Uncertain significance Single submitter
- CCDC181 p.Cys190Phe Uncertain significance Single submitter
- CCDC181 p.Cys209Arg Uncertain significance Single submitter
- CCDC181 p.Cys209Ser Uncertain significance Single submitter
- CCDC181 p.Gln157His Uncertain significance Single submitter
- CCDC181 p.Gln253Arg Uncertain significance Single submitter
- CCDC181 p.Glu110Gly Uncertain significance Single submitter
- CCDC181 p.Glu117Asp Uncertain significance Single submitter
- CCDC181 p.Glu16Lys Uncertain significance Single submitter
- CCDC181 p.Glu270Gly Uncertain significance Single submitter
- CCDC181 p.Glu434Lys Uncertain significance Single submitter
- CCDC181 p.Glu75Ala Uncertain significance Single submitter
- CCDC181 p.Gly266Ser Uncertain significance Single submitter
- CCDC181 p.His492Tyr Uncertain significance Single submitter
- CCDC181 p.Ile326Thr Uncertain significance Single submitter
- CCDC181 p.Ile37Val Uncertain significance Single submitter
- CCDC181 p.Ile83Val Uncertain significance Single submitter
- CCDC181 p.Leu109Pro Uncertain significance Single submitter
- CCDC181 p.Lys108Gln Uncertain significance Single submitter
- CCDC181 p.Lys185Gln Uncertain significance Single submitter
- CCDC181 p.Lys369Gln Uncertain significance Single submitter
- CCDC181 p.Lys446Glu Uncertain significance Single submitter
- CCDC181 p.Met182Ile Uncertain significance Single submitter
- CCDC181 p.Met182Thr Uncertain significance Single submitter
- CCDC181 p.Met496Thr Uncertain significance Single submitter
- CCDC181 p.Phe104Cys Uncertain significance Single submitter
- CCDC181 p.Pro287Leu Uncertain significance Single submitter
- CCDC181 p.Pro337Ser Uncertain significance Single submitter
- CCDC181 p.Pro87Leu Uncertain significance Single submitter
- CCDC181 p.Pro94Thr Uncertain significance Single submitter
- CCDC181 p.Thr170Ala Uncertain significance Single submitter
- CCDC181 p.Thr332Ala Uncertain significance Single submitter
- CCDC181 p.Thr332Pro Uncertain significance Single submitter
- CCDC181 p.Thr57Ala Uncertain significance Single submitter
- CCDC181 p.Val86Ala Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CCDC181 p.Ala414Pro Uncertain significance Single submitter
- CCDC181 p.Ala468Pro Uncertain significance Single submitter
- CCDC181 p.Arg150Gln Uncertain significance Single submitter
- CCDC181 p.Arg298Cys Uncertain significance Single submitter
- CCDC181 p.Arg395Pro Uncertain significance Single submitter
- CCDC181 p.Arg463Trp Uncertain significance Single submitter
- CCDC181 p.Arg486His Uncertain significance Single submitter
- CCDC181 p.Arg64Trp Uncertain significance Single submitter
- CCDC181 p.Asn2His Uncertain significance Single submitter
- CCDC181 p.Asp194Tyr Uncertain significance Single submitter
- CCDC181 p.Asp199Tyr Uncertain significance Single submitter
- CCDC181 p.Gln381Pro Uncertain significance Single submitter
- CCDC181 p.Gln394Pro Uncertain significance Single submitter
- CCDC181 p.Glu13Lys Uncertain significance Single submitter
- CCDC181 p.Glu167Gly Uncertain significance Single submitter
- CCDC181 p.Glu177Ala Uncertain significance Single submitter
- CCDC181 p.Glu356Gln Uncertain significance Single submitter
- CCDC181 p.Glu367Asp Uncertain significance Single submitter
- CCDC181 p.Glu389Gly Uncertain significance Single submitter
- CCDC181 p.Glu429Asp Uncertain significance Single submitter
- CCDC181 p.Glu439Val Uncertain significance Single submitter
- CCDC181 p.Leu335Phe Uncertain significance Single submitter
- CCDC181 p.Lys437Asn Uncertain significance Single submitter
- CCDC181 p.Pro143Leu Uncertain significance Single submitter
- CCDC181 p.Ser100Asn Uncertain significance Single submitter
- CCDC181 p.Ser263Cys Uncertain significance Single submitter
- CCDC181 p.Ser36Arg Uncertain significance Single submitter
- CCDC181 p.Val387Phe Uncertain significance Single submitter
All CCDC181 variants
Likely benign 5
- p.Arg474Lys Single submitter
- p.Lys44Asn Single submitter
- p.Pro294= Single submitter
- p.Thr273Ala Single submitter
- p.Thr273Ile Single submitter
Uncertain significance 72
- p.Ala292Thr Single submitter ⚠
- p.Ala414Pro Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Ala468Pro Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg298Cys Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg395Pro Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg460Ile Single submitter ⚠
- p.Arg463Trp Single submitter ⚠
- p.Arg481Gln Single submitter ⚠
- p.Arg486His Single submitter ⚠
- p.Arg503His Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Asn178Lys Single submitter ⚠
- p.Asn181Ser Single submitter ⚠
- p.Asn2His Single submitter ⚠
- p.Asn307Ser Single submitter ⚠
- p.Asp194Tyr Single submitter ⚠
- p.Asp199Tyr Single submitter ⚠
- p.Cys190Phe Single submitter ⚠
- p.Cys209Arg Single submitter ⚠
- p.Cys209Ser Single submitter ⚠
- p.Gln157His Single submitter ⚠
- p.Gln253Arg Single submitter ⚠
- p.Gln381Pro Single submitter ⚠
- p.Gln394Pro Single submitter ⚠
- p.Glu110Gly Single submitter ⚠
- p.Glu117Asp Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Glu167Gly Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu177Ala Single submitter ⚠
- p.Glu270Gly Single submitter ⚠
- p.Glu356Gln Single submitter ⚠
- p.Glu367Asp Single submitter ⚠
- p.Glu389Gly Single submitter ⚠
- p.Glu429Asp Single submitter ⚠
- p.Glu434Lys Single submitter ⚠
- p.Glu439Val Single submitter ⚠
- p.Glu75Ala Single submitter ⚠
- p.Gly266Ser Single submitter ⚠
- p.His492Tyr Single submitter ⚠
- p.Ile326Thr Single submitter ⚠
- p.Ile37Val Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu335Phe Single submitter ⚠
- p.Lys108Gln Single submitter ⚠
- p.Lys185Gln Single submitter ⚠
- p.Lys369Gln Single submitter ⚠
- p.Lys437Asn Single submitter ⚠
- p.Lys446Glu Single submitter ⚠
- p.Met182Ile Single submitter ⚠
- p.Met182Thr Single submitter ⚠
- p.Met496Thr Single submitter ⚠
- p.Phe104Cys Single submitter ⚠
- p.Pro143Leu Single submitter ⚠
- p.Pro287Leu Single submitter ⚠
- p.Pro337Ser Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Pro94Thr Single submitter ⚠
- p.Ser100Asn Single submitter ⚠
- p.Ser263Cys Single submitter ⚠
- p.Ser36Arg Single submitter ⚠
- p.Thr170Ala Single submitter ⚠
- p.Thr332Ala Single submitter ⚠
- p.Thr332Pro Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Val387Phe Single submitter ⚠
- p.Val86Ala Single submitter ⚠