CCDC184 — 35 ClinVar variants
All ClinVar germline CCDC184 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Likely benign · 34 Uncertain significance
Full CCDC184 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC184 p.Ala151Thr Uncertain significance Single submitter
- CCDC184 p.Asp137His Uncertain significance Single submitter
- CCDC184 p.Gln112Arg Uncertain significance Single submitter
- CCDC184 p.Glu119Ala Uncertain significance Single submitter
- CCDC184 p.Glu136Val Uncertain significance Single submitter
- CCDC184 p.Glu138Ala Uncertain significance Single submitter
- CCDC184 p.Glu138Gln Uncertain significance Single submitter
- CCDC184 p.Glu138Lys Uncertain significance Single submitter
- CCDC184 p.Glu144Asp Uncertain significance Single submitter
- CCDC184 p.Glu158Gln Uncertain significance Single submitter
- CCDC184 p.Glu7Gly Uncertain significance Single submitter
- CCDC184 p.Gly124Glu Uncertain significance Single submitter
- CCDC184 p.Gly129Ser Uncertain significance Single submitter
- CCDC184 p.Gly14Ser Uncertain significance Single submitter
- CCDC184 p.Gly170Arg Uncertain significance Single submitter
- CCDC184 p.Gly190Ser Uncertain significance Single submitter
- CCDC184 p.Leu102Ser Uncertain significance Single submitter
- CCDC184 p.Pro160Ser Uncertain significance Single submitter
- CCDC184 p.Pro177Thr Uncertain significance Single submitter
- CCDC184 p.Pro17Ser Uncertain significance Single submitter
- CCDC184 p.Ser128Asn Uncertain significance Single submitter
- CCDC184 p.Ser128Gly Uncertain significance Single submitter
- CCDC184 p.Ser23Pro Uncertain significance Single submitter
- CCDC184 p.Val175Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CCDC184 p.Arg62Ser Uncertain significance Single submitter
- CCDC184 p.Gln50His Uncertain significance Single submitter
- CCDC184 p.Leu43Pro Uncertain significance Single submitter
- CCDC184 p.Met89Lys Uncertain significance Single submitter
- CCDC184 p.Met9Ile Uncertain significance Single submitter
- CCDC184 p.Thr10Ile Uncertain significance Single submitter
- CCDC184 p.Thr94Ser Uncertain significance Single submitter
- CCDC184 p.Val31Met Uncertain significance Single submitter
- CCDC184 p.Val79Met Uncertain significance Single submitter
All CCDC184 variants
Likely benign 1
- p.Ser122= Single submitter
Uncertain significance 34
- p.Ala151Thr Single submitter ⚠
- p.Arg62Ser Single submitter ⚠
- p.Asp137His Single submitter ⚠
- p.Gln112Arg Single submitter ⚠
- p.Gln50His Single submitter ⚠
- p.Glu119Ala Single submitter ⚠
- p.Glu136Val Single submitter ⚠
- p.Glu138Ala Single submitter ⚠
- p.Glu138Gln Single submitter ⚠
- p.Glu138Lys Single submitter ⚠
- p.Glu144Asp Single submitter ⚠
- p.Glu158Gln Single submitter ⚠
- p.Glu7Gly Single submitter ⚠
- p.Gly124Glu Single submitter ⚠
- p.Gly129Ser Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly190Asp Single submitter
- p.Gly190Ser Single submitter ⚠
- p.Leu102Ser Single submitter ⚠
- p.Leu43Pro Single submitter ⚠
- p.Met89Lys Single submitter ⚠
- p.Met9Ile Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro177Thr Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Ser128Asn Single submitter ⚠
- p.Ser128Gly Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr94Ser Single submitter ⚠
- p.Val175Leu Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val79Met Single submitter ⚠