CCDC185 — 137 ClinVar variants
All ClinVar germline CCDC185 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 132 flagged for review →
6 Likely benign · 131 Uncertain significance
Full CCDC185 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 132
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC185 p.Ala364Val Uncertain significance Single submitter
- CCDC185 p.Ala404Thr Uncertain significance Single submitter
- CCDC185 p.Ala432Gly Uncertain significance Single submitter
- CCDC185 p.Ala441Ser Uncertain significance Single submitter
- CCDC185 p.Ala441Thr Uncertain significance Single submitter
- CCDC185 p.Ala510Val Uncertain significance Single submitter
- CCDC185 p.Ala55Val Uncertain significance Single submitter
- CCDC185 p.Ala616Pro Uncertain significance Single submitter
- CCDC185 p.Arg13Pro Uncertain significance Single submitter
- CCDC185 p.Arg13Trp Uncertain significance Single submitter
- CCDC185 p.Arg182Cys Uncertain significance Single submitter
- CCDC185 p.Arg182His Uncertain significance Single submitter
- CCDC185 p.Arg192Gln Uncertain significance Single submitter
- CCDC185 p.Arg25Leu Uncertain significance Single submitter
- CCDC185 p.Arg303Gln Uncertain significance Single submitter
- CCDC185 p.Arg332Gln Uncertain significance Single submitter
- CCDC185 p.Arg387Gly Uncertain significance Single submitter
- CCDC185 p.Arg390Gln Uncertain significance Single submitter
- CCDC185 p.Arg406Leu Uncertain significance Single submitter
- CCDC185 p.Arg45Gln Uncertain significance Single submitter
- CCDC185 p.Arg470Gln Uncertain significance Single submitter
- CCDC185 p.Arg598Thr Uncertain significance Single submitter
- CCDC185 p.Arg621Lys Uncertain significance Single submitter
- CCDC185 p.Asn338Ile Uncertain significance Single submitter
- CCDC185 p.Asp144Ala Uncertain significance Single submitter
- CCDC185 p.Asp14Val Uncertain significance Single submitter
- CCDC185 p.Asp170Ala Uncertain significance Single submitter
- CCDC185 p.Asp333Asn Uncertain significance Single submitter
- CCDC185 p.Asp39Asn Uncertain significance Single submitter
- CCDC185 p.Gln258Arg Uncertain significance Single submitter
- CCDC185 p.Gln353Lys Uncertain significance Single submitter
- CCDC185 p.Gln358Arg Uncertain significance Single submitter
- CCDC185 p.Gln358Glu Uncertain significance Single submitter
- CCDC185 p.Gln373Arg Uncertain significance Single submitter
- CCDC185 p.Gln416Arg Uncertain significance Single submitter
- CCDC185 p.Gln440Arg Uncertain significance Single submitter
- CCDC185 p.Gln484Arg Uncertain significance Single submitter
- CCDC185 p.Gln587Arg Uncertain significance Single submitter
- CCDC185 p.Glu26Lys Uncertain significance Single submitter
- CCDC185 p.Glu311Lys Uncertain significance Single submitter
- CCDC185 p.Glu348Val Uncertain significance Single submitter
- CCDC185 p.Glu445Asp Uncertain significance Single submitter
- CCDC185 p.Glu611Asp Uncertain significance Single submitter
- CCDC185 p.Gly111Arg Uncertain significance Single submitter
- CCDC185 p.Gly143Glu Uncertain significance Single submitter
- CCDC185 p.Gly152Glu Uncertain significance Single submitter
- CCDC185 p.Gly159Cys Uncertain significance Single submitter
- CCDC185 p.Gly23Arg Uncertain significance Single submitter
- CCDC185 p.Gly37Arg Uncertain significance Single submitter
- CCDC185 p.Gly47Arg Uncertain significance Single submitter
- CCDC185 p.Gly81Asp Uncertain significance Single submitter
- CCDC185 p.Gly81Ser Uncertain significance Single submitter
- CCDC185 p.His463Gln Uncertain significance Single submitter
- CCDC185 p.His463Tyr Uncertain significance Single submitter
- CCDC185 p.His531Gln Uncertain significance Single submitter
- CCDC185 p.His63Arg Uncertain significance Single submitter
- CCDC185 p.His63Pro Uncertain significance Single submitter
- CCDC185 p.Leu305Val Uncertain significance Single submitter
- CCDC185 p.Leu31Pro Uncertain significance Single submitter
- CCDC185 p.Leu330Val Uncertain significance Single submitter
- CCDC185 p.Lys503Arg Uncertain significance Single submitter
- CCDC185 p.Lys528Glu Uncertain significance Single submitter
- CCDC185 p.Met296Thr Uncertain significance Single submitter
- CCDC185 p.Met437Thr Uncertain significance Single submitter
- CCDC185 p.Met437Val Uncertain significance Single submitter
- CCDC185 p.Met501Ile Uncertain significance Single submitter
- CCDC185 p.Pro123Thr Uncertain significance Single submitter
- CCDC185 p.Pro129Ser Uncertain significance Single submitter
- CCDC185 p.Pro132Leu Uncertain significance Single submitter
- CCDC185 p.Pro139Ser Uncertain significance Single submitter
- CCDC185 p.Pro147Leu Uncertain significance Single submitter
- CCDC185 p.Pro196Thr Uncertain significance Single submitter
- CCDC185 p.Pro19Gln Uncertain significance Single submitter
- CCDC185 p.Pro340Leu Uncertain significance Single submitter
- CCDC185 p.Pro341Arg Uncertain significance Single submitter
- CCDC185 p.Pro49Gln Uncertain significance Single submitter
- CCDC185 p.Pro92Ala Uncertain significance Single submitter
- CCDC185 p.Ser215Arg Uncertain significance Single submitter
- CCDC185 p.Ser394Asn Uncertain significance Single submitter
- CCDC185 p.Thr240Ala Uncertain significance Single submitter
- CCDC185 p.Val174Leu Uncertain significance Single submitter
- CCDC185 p.Val188Ile Uncertain significance Single submitter
- CCDC185 p.Val252Leu Uncertain significance Single submitter
- CCDC185 p.Val294Ile Uncertain significance Single submitter
- CCDC185 p.Val376Leu Uncertain significance Single submitter
- CCDC185 p.Val413Leu Uncertain significance Single submitter
- CCDC185 p.Val413Met Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- CCDC185 p.Ala564Thr Uncertain significance Single submitter
- CCDC185 p.Arg100Trp Uncertain significance Single submitter
- CCDC185 p.Arg118His Uncertain significance Single submitter
- CCDC185 p.Arg131Trp Uncertain significance Single submitter
- CCDC185 p.Arg192Trp Uncertain significance Single submitter
- CCDC185 p.Arg302His Uncertain significance Single submitter
- CCDC185 p.Arg303Trp Uncertain significance Single submitter
- CCDC185 p.Arg307Trp Uncertain significance Single submitter
- CCDC185 p.Arg319His Uncertain significance Single submitter
- CCDC185 p.Arg332Trp Uncertain significance Single submitter
- CCDC185 p.Arg365Cys Uncertain significance Single submitter
- CCDC185 p.Arg378Gly Uncertain significance Single submitter
- CCDC185 p.Arg387Trp Uncertain significance Single submitter
- CCDC185 p.Arg390Trp Uncertain significance Single submitter
- CCDC185 p.Arg458Gln Uncertain significance Single submitter
- CCDC185 p.Arg472Gly Uncertain significance Single submitter
- CCDC185 p.Arg491Pro Uncertain significance Single submitter
- CCDC185 p.Arg502Cys Uncertain significance Single submitter
- CCDC185 p.Arg504Ile Uncertain significance Single submitter
- CCDC185 p.Arg533Trp Uncertain significance Single submitter
- CCDC185 p.Cys439Trp Uncertain significance Single submitter
- CCDC185 p.Gln255His Uncertain significance Single submitter
- CCDC185 p.Gln464His Uncertain significance Single submitter
- CCDC185 p.Glu301Asp Uncertain significance Single submitter
- CCDC185 p.Glu403Asp Uncertain significance Single submitter
- CCDC185 p.Glu512Asp Uncertain significance Single submitter
- CCDC185 p.Glu569Gly Uncertain significance Single submitter
- CCDC185 p.Gly56Val Uncertain significance Single submitter
- CCDC185 p.His537Pro Uncertain significance Single submitter
- CCDC185 p.His557Leu Uncertain significance Single submitter
- CCDC185 p.Leu298Pro Uncertain significance Single submitter
- CCDC185 p.Leu397Pro Uncertain significance Single submitter
- CCDC185 p.Leu424Met Uncertain significance Single submitter
- CCDC185 p.Leu436Pro Uncertain significance Single submitter
- CCDC185 p.Leu474Pro Uncertain significance Single submitter
- CCDC185 p.Leu605Phe Likely benign Single submitter
- CCDC185 p.Lys549Asn Uncertain significance Single submitter
- CCDC185 p.Lys555Asn Uncertain significance Single submitter
- CCDC185 p.Ser40Phe Uncertain significance Single submitter
- CCDC185 p.Ser96Phe Uncertain significance Single submitter
- CCDC185 p.Thr28Met Uncertain significance Single submitter
- CCDC185 p.Thr67Ile Uncertain significance Single submitter
- CCDC185 p.Trp313Arg Uncertain significance Single submitter
- CCDC185 p.Val163Ile Uncertain significance Single submitter
- CCDC185 p.Val195Met Uncertain significance Single submitter
All CCDC185 variants
Likely benign 6
- p.Arg387Gln Single submitter
- p.Leu229Ser Single submitter
- p.Leu605Phe Single submitter ⚠
- p.Phe583Leu Single submitter
- p.Pro356= Single submitter
- p.Ser76Pro Single submitter
Uncertain significance 131
- p.Ala364Val Single submitter ⚠
- p.Ala404Thr Single submitter ⚠
- p.Ala432Gly Single submitter ⚠
- p.Ala441Ser Single submitter ⚠
- p.Ala441Thr Single submitter ⚠
- p.Ala510Val Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Ala564Thr Single submitter ⚠
- p.Ala616Pro Single submitter ⚠
- p.Arg100Trp Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg131Trp Single submitter ⚠
- p.Arg13Pro Single submitter ⚠
- p.Arg13Trp Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg25Leu Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg303Trp Single submitter ⚠
- p.Arg307Trp Single submitter ⚠
- p.Arg319His Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg378Gly Single submitter ⚠
- p.Arg387Gly Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg390Gln Single submitter ⚠
- p.Arg390Trp Single submitter ⚠
- p.Arg406Leu Single submitter ⚠
- p.Arg458Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg472Gly Single submitter ⚠
- p.Arg491Pro Single submitter ⚠
- p.Arg502Cys Single submitter ⚠
- p.Arg504Ile Single submitter ⚠
- p.Arg533Trp Single submitter ⚠
- p.Arg598Thr Single submitter ⚠
- p.Arg621Lys Single submitter ⚠
- p.Asn338Ile Single submitter ⚠
- p.Asp144Ala Single submitter ⚠
- p.Asp14Val Single submitter ⚠
- p.Asp170Ala Single submitter ⚠
- p.Asp333Asn Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Cys439Trp Single submitter ⚠
- p.Gln255His Single submitter ⚠
- p.Gln258Arg Single submitter ⚠
- p.Gln353Lys Single submitter ⚠
- p.Gln358Arg Single submitter ⚠
- p.Gln358Glu Single submitter ⚠
- p.Gln373Arg Single submitter ⚠
- p.Gln416Arg Single submitter ⚠
- p.Gln440Arg Single submitter ⚠
- p.Gln464His Single submitter ⚠
- p.Gln484Arg Single submitter ⚠
- p.Gln587Arg Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu348Val Single submitter ⚠
- p.Glu403Asp Single submitter ⚠
- p.Glu445Asp Single submitter ⚠
- p.Glu512Asp Single submitter ⚠
- p.Glu569Gly Single submitter ⚠
- p.Glu611Asp Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly143Glu Single submitter ⚠
- p.Gly152Glu Single submitter ⚠
- p.Gly159Cys Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Gly56Val Single submitter ⚠
- p.Gly81Asp Single submitter ⚠
- p.Gly81Ser Single submitter ⚠
- p.His463Gln Single submitter ⚠
- p.His463Tyr Single submitter ⚠
- p.His531Gln Single submitter ⚠
- p.His537Pro Single submitter ⚠
- p.His557Leu Single submitter ⚠
- p.His63Arg Single submitter ⚠
- p.His63Pro Single submitter ⚠
- p.Leu298Pro Single submitter ⚠
- p.Leu305Val Single submitter ⚠
- p.Leu31Pro Single submitter ⚠
- p.Leu330Val Single submitter ⚠
- p.Leu397Pro Single submitter ⚠
- p.Leu424Met Single submitter ⚠
- p.Leu436Pro Single submitter ⚠
- p.Leu474Pro Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys528Glu Single submitter ⚠
- p.Lys549Asn Single submitter ⚠
- p.Lys555Asn Single submitter ⚠
- p.Met296Thr Single submitter ⚠
- p.Met437Thr Single submitter ⚠
- p.Met437Val Single submitter ⚠
- p.Met501Ile Single submitter ⚠
- p.Pro123Thr Single submitter ⚠
- p.Pro129Ser Single submitter ⚠
- p.Pro132Leu Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro196Thr Single submitter ⚠
- p.Pro19Gln Single submitter ⚠
- p.Pro340Leu Single submitter ⚠
- p.Pro341Arg Single submitter ⚠
- p.Pro49Gln Single submitter ⚠
- p.Pro92Ala Single submitter ⚠
- p.Ser215Arg Single submitter ⚠
- p.Ser394Asn Single submitter ⚠
- p.Ser40Phe Single submitter ⚠
- p.Ser96Phe Single submitter ⚠
- p.Thr240Ala Single submitter ⚠
- p.Thr28Met Single submitter ⚠
- p.Thr67Ile Single submitter ⚠
- p.Trp313Arg Single submitter ⚠
- p.Val163Ile Single submitter ⚠
- p.Val174Leu Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val195Met Single submitter ⚠
- p.Val252Leu Single submitter ⚠
- p.Val294Ile Single submitter ⚠
- p.Val376Leu Single submitter ⚠
- p.Val413Leu Single submitter ⚠
- p.Val413Met Single submitter ⚠