Sugi Variant

Sugi Variant/CCDC186

CCDC186 — 118 ClinVar variants

All ClinVar germline CCDC186 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →

1 Pathogenic · 2 Benign · 4 Likely benign · 111 Uncertain significance

Full CCDC186 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 106

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 62

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 44

The independent predictors disagree with each other — read with care.

All CCDC186 variants

Pathogenic 1

Benign 2

Likely benign 4

Uncertain significance 111