CCDC190 — 45 ClinVar variants
All ClinVar germline CCDC190 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
6 Likely benign · 39 Uncertain significance
Full CCDC190 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC190 p.Ala107Thr Uncertain significance Single submitter
- CCDC190 p.Ala24Thr Uncertain significance Single submitter
- CCDC190 p.Arg259Trp Uncertain significance Single submitter
- CCDC190 p.Arg7Lys Uncertain significance Single submitter
- CCDC190 p.Asp160Tyr Uncertain significance Single submitter
- CCDC190 p.Asp169Tyr Uncertain significance Single submitter
- CCDC190 p.Asp218Gly Uncertain significance Single submitter
- CCDC190 p.Asp83Asn Uncertain significance Single submitter
- CCDC190 p.Cys115Ser Uncertain significance Single submitter
- CCDC190 p.Cys290Arg Uncertain significance Single submitter
- CCDC190 p.Cys39Ser Uncertain significance Single submitter
- CCDC190 p.Gln99His Uncertain significance Single submitter
- CCDC190 p.Glu182Val Uncertain significance Single submitter
- CCDC190 p.Glu231Gln Uncertain significance Single submitter
- CCDC190 p.Gly219Arg Uncertain significance Single submitter
- CCDC190 p.Gly273Glu Uncertain significance Single submitter
- CCDC190 p.Ile188Val Uncertain significance Single submitter
- CCDC190 p.Leu140Phe Uncertain significance Single submitter
- CCDC190 p.Lys12Glu Uncertain significance Single submitter
- CCDC190 p.Lys228Gln Uncertain significance Single submitter
- CCDC190 p.Lys44Gln Uncertain significance Single submitter
- CCDC190 p.Met133Arg Uncertain significance Single submitter
- CCDC190 p.Met133Ile Uncertain significance Single submitter
- CCDC190 p.Phe69Ser Uncertain significance Single submitter
- CCDC190 p.Pro154Leu Uncertain significance Single submitter
- CCDC190 p.Pro170Leu Uncertain significance Single submitter
- CCDC190 p.Pro196Gln Uncertain significance Single submitter
- CCDC190 p.Pro300Ser Uncertain significance Single submitter
- CCDC190 p.Pro81Gln Uncertain significance Single submitter
- CCDC190 p.Ser124Ala Uncertain significance Single submitter
- CCDC190 p.Ser281Ala Uncertain significance Single submitter
- CCDC190 p.Ser296Tyr Uncertain significance Single submitter
- CCDC190 p.Ser70Phe Uncertain significance Single submitter
- CCDC190 p.Ser88Leu Uncertain significance Single submitter
- CCDC190 p.Val6Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CCDC190 variants
Likely benign 6
- p.Arg59Lys Single submitter
- p.Cys204Arg Single submitter
- p.Ile150Thr Single submitter
- p.Pro139Leu Single submitter
- p.Ser282Leu Single submitter
- p.Val168Ile Single submitter
Uncertain significance 39
- p.Ala107Thr Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Arg259Gly Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg7Lys Single submitter ⚠
- p.Asp160Tyr Single submitter ⚠
- p.Asp169Tyr Single submitter ⚠
- p.Asp218Gly Single submitter ⚠
- p.Asp83Asn Single submitter ⚠
- p.Cys115Ser Single submitter ⚠
- p.Cys290Arg Single submitter ⚠
- p.Cys39Ser Single submitter ⚠
- p.Gln99His Single submitter ⚠
- p.Glu182Val Single submitter ⚠
- p.Glu231Gln Single submitter ⚠
- p.Gly219Arg Single submitter ⚠
- p.Gly273Glu Single submitter ⚠
- p.Ile188Val Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Lys12Glu Single submitter ⚠
- p.Lys228Gln Single submitter ⚠
- p.Lys44Gln Single submitter ⚠
- p.Met133Arg Single submitter ⚠
- p.Met133Ile Single submitter ⚠
- p.Phe69Ser Single submitter ⚠
- p.Pro154Leu Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro196Gln Single submitter ⚠
- p.Pro264Arg Single submitter ⚠
- p.Pro300Ser Single submitter ⚠
- p.Pro81Gln Single submitter ⚠
- p.Ser124Ala Single submitter ⚠
- p.Ser271Arg Single submitter ⚠
- p.Ser281Ala Single submitter ⚠
- p.Ser296Tyr Single submitter ⚠
- p.Ser70Phe Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Val6Ala Single submitter ⚠