CCDC24 — 42 ClinVar variants
All ClinVar germline CCDC24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
5 Likely benign · 37 Uncertain significance
Full CCDC24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC24 p.Ala294Ser Uncertain significance Single submitter
- CCDC24 p.Ala305Thr Uncertain significance Single submitter
- CCDC24 p.Ala44Ser Uncertain significance Single submitter
- CCDC24 p.Arg178Lys Uncertain significance Single submitter
- CCDC24 p.Arg178Ser Uncertain significance Single submitter
- CCDC24 p.Arg22Cys Uncertain significance Single submitter
- CCDC24 p.Arg280Cys Uncertain significance Single submitter
- CCDC24 p.Arg280His Uncertain significance Single submitter
- CCDC24 p.Arg280Leu Uncertain significance Single submitter
- CCDC24 p.Arg62Cys Uncertain significance Single submitter
- CCDC24 p.Asp66Asn Uncertain significance Single submitter
- CCDC24 p.Gln133His Uncertain significance Single submitter
- CCDC24 p.Gln235His Uncertain significance Single submitter
- CCDC24 p.Glu130Gln Uncertain significance Single submitter
- CCDC24 p.Glu188Gly Uncertain significance Single submitter
- CCDC24 p.Glu219Lys Uncertain significance Single submitter
- CCDC24 p.Glu30Gln Uncertain significance Single submitter
- CCDC24 p.Glu52Gly Uncertain significance Single submitter
- CCDC24 p.His15Asp Uncertain significance Single submitter
- CCDC24 p.Ile97Thr Uncertain significance Single submitter
- CCDC24 p.Leu28Pro Uncertain significance Single submitter
- CCDC24 p.Phe132Leu Uncertain significance Single submitter
- CCDC24 p.Pro247Ser Uncertain significance Single submitter
- CCDC24 p.Pro256Leu Uncertain significance Single submitter
- CCDC24 p.Pro297Leu Uncertain significance Single submitter
- CCDC24 p.Pro6Leu Uncertain significance Single submitter
- CCDC24 p.Ser147Ile Uncertain significance Single submitter
- CCDC24 p.Ser5Cys Uncertain significance Single submitter
- CCDC24 p.Thr205Pro Uncertain significance Single submitter
- CCDC24 p.Val155Ala Uncertain significance Single submitter
- CCDC24 p.Val155Met Uncertain significance Single submitter
- CCDC24 p.Val161Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CCDC24 variants
Likely benign 5
- p.Arg273Gln Single submitter
- p.His94Gln Single submitter
- p.Ile97= Single submitter
- p.Pro248Leu Single submitter
- p.Pro303Ser Single submitter
Uncertain significance 37
- p.Ala294Ser Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala44Ser Single submitter ⚠
- p.Arg178Lys Single submitter ⚠
- p.Arg178Ser Single submitter ⚠
- p.Arg22Cys Single submitter ⚠
- p.Arg280Cys Single submitter ⚠
- p.Arg280His Single submitter ⚠
- p.Arg280Leu Single submitter ⚠
- p.Arg54Pro Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asp102Gly Single submitter
- p.Asp66Asn Single submitter ⚠
- p.Gln133His Single submitter ⚠
- p.Gln235His Single submitter ⚠
- p.Glu130Gln Single submitter ⚠
- p.Glu188Gly Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu30Gln Single submitter ⚠
- p.Glu52Gly Single submitter ⚠
- p.His15Asp Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu28Pro Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Phe132Leu Single submitter ⚠
- p.Pro247Ser Single submitter ⚠
- p.Pro256Leu Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Ser147Ile Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Thr205Pro Single submitter ⚠
- p.Val155Ala Single submitter ⚠
- p.Val155Met Single submitter ⚠
- p.Val161Leu Single submitter ⚠
- p.Val161Met Single submitter ⚠