CCDC25 — 30 ClinVar variants
All ClinVar germline CCDC25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
30 Uncertain significance
Full CCDC25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC25 p.Arg178Lys Uncertain significance Single submitter
- CCDC25 p.Asn202Ser Uncertain significance Single submitter
- CCDC25 p.Asp200Val Uncertain significance Single submitter
- CCDC25 p.His55Arg Uncertain significance Single submitter
- CCDC25 p.His73Gln Uncertain significance Single submitter
- CCDC25 p.Ile109Thr Uncertain significance Single submitter
- CCDC25 p.Ile17Val Uncertain significance Single submitter
- CCDC25 p.Ile30Met Uncertain significance Single submitter
- CCDC25 p.Ile80Phe Uncertain significance Single submitter
- CCDC25 p.Leu68Arg Uncertain significance Single submitter
- CCDC25 p.Lys31Arg Uncertain significance Single submitter
- CCDC25 p.Met19Thr Uncertain significance Single submitter
- CCDC25 p.Pro142Ser Uncertain significance Single submitter
- CCDC25 p.Pro94Leu Uncertain significance Single submitter
- CCDC25 p.Ser13Tyr Uncertain significance Single submitter
- CCDC25 p.Thr136Ile Uncertain significance Single submitter
- CCDC25 p.Thr93Met Uncertain significance Single submitter
- CCDC25 p.Trp34Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CCDC25 p.Arg140Gln Uncertain significance Single submitter
- CCDC25 p.Arg140Trp Uncertain significance Single submitter
- CCDC25 p.Arg153Cys Uncertain significance Single submitter
- CCDC25 p.Arg153His Uncertain significance Single submitter
- CCDC25 p.Asn198Asp Uncertain significance Single submitter
- CCDC25 p.Asn87Ser Uncertain significance Single submitter
- CCDC25 p.Gln81Lys Uncertain significance Single submitter
- CCDC25 p.Glu172Lys Uncertain significance Single submitter
- CCDC25 p.Leu45Val Uncertain significance Single submitter
- CCDC25 p.Lys44Arg Uncertain significance Single submitter
- CCDC25 p.Met195Thr Uncertain significance Single submitter
- CCDC25 p.Phe141Leu Uncertain significance Single submitter
All CCDC25 variants
Uncertain significance 30
- p.Arg140Gln Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg178Lys Single submitter ⚠
- p.Asn198Asp Single submitter ⚠
- p.Asn202Ser Single submitter ⚠
- p.Asn87Ser Single submitter ⚠
- p.Asp200Val Single submitter ⚠
- p.Gln81Lys Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.His55Arg Single submitter ⚠
- p.His73Gln Single submitter ⚠
- p.Ile109Thr Single submitter ⚠
- p.Ile17Val Single submitter ⚠
- p.Ile30Met Single submitter ⚠
- p.Ile80Phe Single submitter ⚠
- p.Leu45Val Single submitter ⚠
- p.Leu68Arg Single submitter ⚠
- p.Lys31Arg Single submitter ⚠
- p.Lys44Arg Single submitter ⚠
- p.Met195Thr Single submitter ⚠
- p.Met19Thr Single submitter ⚠
- p.Phe141Leu Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser13Tyr Single submitter ⚠
- p.Thr136Ile Single submitter ⚠
- p.Thr93Met Single submitter ⚠
- p.Trp34Cys Single submitter ⚠