CCDC28A — 34 ClinVar variants
All ClinVar germline CCDC28A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Likely benign · 33 Uncertain significance
Full CCDC28A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC28A c.-104C>T Uncertain significance Single submitter
- CCDC28A c.-113C>A Uncertain significance Single submitter
- CCDC28A c.-129G>A Uncertain significance Single submitter
- CCDC28A c.-132G>C Uncertain significance Single submitter
- CCDC28A c.-134C>G Uncertain significance Single submitter
- CCDC28A c.-155G>A Uncertain significance Single submitter
- CCDC28A c.-23G>T Uncertain significance Single submitter
- CCDC28A c.-58T>G Uncertain significance Single submitter
- CCDC28A c.-59A>G Uncertain significance Single submitter
- CCDC28A c.-62C>G Uncertain significance Single submitter
- CCDC28A c.-81C>T Uncertain significance Single submitter
- CCDC28A p.Arg120Trp Uncertain significance Single submitter
- CCDC28A p.Arg145Lys Uncertain significance Single submitter
- CCDC28A p.Arg4Gln Uncertain significance Single submitter
- CCDC28A p.Asp154Tyr Uncertain significance Single submitter
- CCDC28A p.Asp177His Uncertain significance Single submitter
- CCDC28A p.Gln62Glu Uncertain significance Single submitter
- CCDC28A p.Gly135Trp Uncertain significance Single submitter
- CCDC28A p.His17Gln Uncertain significance Single submitter
- CCDC28A p.His17Leu Uncertain significance Single submitter
- CCDC28A p.Leu93Ile Uncertain significance Single submitter
- CCDC28A p.Pro73Arg Uncertain significance Single submitter
- CCDC28A p.Ser10Asn Uncertain significance Single submitter
- CCDC28A p.Thr45Ala Uncertain significance Single submitter
- CCDC28A p.Val178Asp Uncertain significance Single submitter
-
CCDC28A p.Val21Ile
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCDC28A c.-138G>A Uncertain significance Single submitter
- CCDC28A c.-9C>T Uncertain significance Single submitter
- CCDC28A p.Arg4Trp Uncertain significance Single submitter
- CCDC28A p.Asp143Gly Uncertain significance Single submitter
- CCDC28A p.Asp159Tyr Uncertain significance Single submitter
- CCDC28A p.Lys144Arg Uncertain significance Single submitter
- CCDC28A p.Pro141Thr Uncertain significance Single submitter
All CCDC28A variants
Likely benign 1
- c.-119T>C Single submitter
Uncertain significance 33
- c.-104C>T Single submitter ⚠
- c.-113C>A Single submitter ⚠
- c.-129G>A Single submitter ⚠
- c.-132G>C Single submitter ⚠
- c.-134C>G Single submitter ⚠
- c.-138G>A Single submitter ⚠
- c.-155G>A Single submitter ⚠
- c.-23G>T Single submitter ⚠
- c.-58T>G Single submitter ⚠
- c.-59A>G Single submitter ⚠
- c.-62C>G Single submitter ⚠
- c.-81C>T Single submitter ⚠
- c.-9C>T Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg145Lys Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg4Trp Single submitter ⚠
- p.Asp143Gly Single submitter ⚠
- p.Asp154Tyr Single submitter ⚠
- p.Asp159Tyr Single submitter ⚠
- p.Asp177His Single submitter ⚠
- p.Gln62Glu Single submitter ⚠
- p.Gly135Trp Single submitter ⚠
- p.His17Gln Single submitter ⚠
- p.His17Leu Single submitter ⚠
- p.Leu93Ile Single submitter ⚠
- p.Lys144Arg Single submitter ⚠
- p.Pro141Thr Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Ser10Asn Single submitter ⚠
- p.Thr45Ala Single submitter ⚠
- p.Val178Asp Single submitter ⚠
- p.Val21Ile No assertion criteria myoepithelial tumor ⚠