CCDC59 — 39 ClinVar variants
All ClinVar germline CCDC59 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 38 Uncertain significance
Full CCDC59 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC59 p.Arg109Gly Uncertain significance Single submitter
- CCDC59 p.Arg5Gly Uncertain significance Single submitter
- CCDC59 p.Arg6Gly Uncertain significance Single submitter
- CCDC59 p.Asp131Glu Uncertain significance Single submitter
- CCDC59 p.Gln238Pro Uncertain significance Single submitter
- CCDC59 p.Gln84Arg Uncertain significance Single submitter
- CCDC59 p.Gly21Glu Uncertain significance Single submitter
- CCDC59 p.His113Asp Uncertain significance Single submitter
- CCDC59 p.Ile159Val Uncertain significance Single submitter
- CCDC59 p.Ile15Met Uncertain significance Single submitter
- CCDC59 p.Ile214Val Uncertain significance Single submitter
- CCDC59 p.Ile63Lys Uncertain significance Single submitter
- CCDC59 p.Leu233Arg Uncertain significance Single submitter
- CCDC59 p.Leu61Gln Uncertain significance Single submitter
- CCDC59 p.Leu93Pro Uncertain significance Single submitter
- CCDC59 p.Lys110Glu Uncertain significance Single submitter
- CCDC59 p.Lys206Asn Uncertain significance Single submitter
- CCDC59 p.Lys68Arg Uncertain significance Single submitter
- CCDC59 p.Pro12Ser Uncertain significance Single submitter
- CCDC59 p.Ser23Pro Uncertain significance Single submitter
- CCDC59 p.Ser83Phe Uncertain significance Single submitter
- CCDC59 p.Thr153Ala Uncertain significance Single submitter
- CCDC59 p.Thr36Ile Uncertain significance Single submitter
- CCDC59 p.Tyr97Cys Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CCDC59 p.Ala184Val Uncertain significance Single submitter
- CCDC59 p.Arg11Trp Uncertain significance Single submitter
- CCDC59 p.Arg50Cys Uncertain significance Single submitter
- CCDC59 p.Arg72Trp Likely benign Single submitter
- CCDC59 p.Asn216Lys Uncertain significance Single submitter
- CCDC59 p.Asp142His Uncertain significance Single submitter
- CCDC59 p.Cys128Arg Uncertain significance Single submitter
- CCDC59 p.Glu189Lys Uncertain significance Single submitter
- CCDC59 p.Glu191Lys Uncertain significance Single submitter
- CCDC59 p.Glu196Gln Uncertain significance Single submitter
- CCDC59 p.Glu199Ala Uncertain significance Single submitter
- CCDC59 p.Lys205Arg Uncertain significance Single submitter
- CCDC59 p.Lys30Asn Uncertain significance Single submitter
- CCDC59 p.Met230Val Uncertain significance Single submitter
- CCDC59 p.Ser7Phe Uncertain significance Single submitter
All CCDC59 variants
Likely benign 1
- p.Arg72Trp Single submitter ⚠
Uncertain significance 38
- p.Ala184Val Single submitter ⚠
- p.Arg109Gly Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Arg50Cys Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Arg6Gly Single submitter ⚠
- p.Asn216Lys Single submitter ⚠
- p.Asp131Glu Single submitter ⚠
- p.Asp142His Single submitter ⚠
- p.Cys128Arg Single submitter ⚠
- p.Gln238Pro Single submitter ⚠
- p.Gln84Arg Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu191Lys Single submitter ⚠
- p.Glu196Gln Single submitter ⚠
- p.Glu199Ala Single submitter ⚠
- p.Gly21Glu Single submitter ⚠
- p.His113Asp Single submitter ⚠
- p.Ile159Val Single submitter ⚠
- p.Ile15Met Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile63Lys Single submitter ⚠
- p.Leu233Arg Single submitter ⚠
- p.Leu61Gln Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Lys110Glu Single submitter ⚠
- p.Lys205Arg Single submitter ⚠
- p.Lys206Asn Single submitter ⚠
- p.Lys30Asn Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met230Val Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser7Phe Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Thr153Ala Single submitter ⚠
- p.Thr36Ile Single submitter ⚠
- p.Tyr97Cys Single submitter ⚠