CCDC60 — 109 ClinVar variants
All ClinVar germline CCDC60 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
5 Likely benign · 104 Uncertain significance
Full CCDC60 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC60 p.Ala159Asp Uncertain significance Single submitter
- CCDC60 p.Ala18Val Uncertain significance Single submitter
- CCDC60 p.Ala214Val Uncertain significance Single submitter
- CCDC60 p.Ala388Thr Uncertain significance Single submitter
- CCDC60 p.Ala451Glu Uncertain significance Single submitter
- CCDC60 p.Ala472Thr Uncertain significance Single submitter
- CCDC60 p.Ala548Thr Uncertain significance Single submitter
- CCDC60 p.Arg131His Uncertain significance Single submitter
- CCDC60 p.Arg20Leu Uncertain significance Single submitter
- CCDC60 p.Arg226Gly Uncertain significance Single submitter
- CCDC60 p.Arg304Gln Uncertain significance Single submitter
- CCDC60 p.Arg308Gln Uncertain significance Single submitter
- CCDC60 p.Arg369Cys Uncertain significance Single submitter
- CCDC60 p.Arg369His Uncertain significance Single submitter
- CCDC60 p.Arg470His Uncertain significance Single submitter
- CCDC60 p.Arg538Gln Uncertain significance Single submitter
- CCDC60 p.Asp43Glu Uncertain significance Single submitter
- CCDC60 p.Asp465Asn Uncertain significance Single submitter
- CCDC60 p.Gln395Arg Uncertain significance Single submitter
- CCDC60 p.Glu119Asp Uncertain significance Single submitter
- CCDC60 p.Glu119Lys Uncertain significance Single submitter
- CCDC60 p.Glu151Lys Uncertain significance Single submitter
- CCDC60 p.Glu301Asp Uncertain significance Single submitter
- CCDC60 p.Glu448Lys Uncertain significance Single submitter
- CCDC60 p.Glu517Gln Uncertain significance Single submitter
- CCDC60 p.Gly236Val Uncertain significance Single submitter
- CCDC60 p.Gly246Arg Uncertain significance Single submitter
- CCDC60 p.Gly247Glu Uncertain significance Single submitter
- CCDC60 p.Gly260Ser Uncertain significance Single submitter
- CCDC60 p.Gly316Arg Uncertain significance Single submitter
- CCDC60 p.Gly544Ala Uncertain significance Single submitter
- CCDC60 p.His171Tyr Uncertain significance Single submitter
- CCDC60 p.His173Gln Uncertain significance Single submitter
- CCDC60 p.His453Arg Uncertain significance Single submitter
- CCDC60 p.Ile106Thr Uncertain significance Single submitter
- CCDC60 p.Ile136Met Uncertain significance Single submitter
- CCDC60 p.Ile136Thr Uncertain significance Single submitter
- CCDC60 p.Ile180Val Uncertain significance Single submitter
- CCDC60 p.Ile313Val Uncertain significance Single submitter
- CCDC60 p.Ile433Val Uncertain significance Single submitter
- CCDC60 p.Ile532Val Uncertain significance Single submitter
- CCDC60 p.Ile543Thr Uncertain significance Single submitter
- CCDC60 p.Ile60Val Uncertain significance Single submitter
- CCDC60 p.Leu145Val Uncertain significance Single submitter
- CCDC60 p.Leu163His Uncertain significance Single submitter
- CCDC60 p.Leu466Ile Uncertain significance Single submitter
- CCDC60 p.Leu476Pro Uncertain significance Single submitter
- CCDC60 p.Leu486Met Uncertain significance Single submitter
- CCDC60 p.Leu486Val Uncertain significance Single submitter
- CCDC60 p.Lys332Glu Uncertain significance Single submitter
- CCDC60 p.Lys404Arg Uncertain significance Single submitter
- CCDC60 p.Lys50Glu Uncertain significance Single submitter
- CCDC60 p.Lys96Thr Uncertain significance Single submitter
- CCDC60 p.Met225Ile Uncertain significance Single submitter
- CCDC60 p.Met36Ile Uncertain significance Single submitter
- CCDC60 p.Met386Thr Uncertain significance Single submitter
- CCDC60 p.Met405Ile Uncertain significance Single submitter
- CCDC60 p.Met405Thr Uncertain significance Single submitter
- CCDC60 p.Pro188Leu Uncertain significance Single submitter
- CCDC60 p.Pro223Ser Uncertain significance Single submitter
- CCDC60 p.Pro232Leu Uncertain significance Single submitter
- CCDC60 p.Pro291Leu Uncertain significance Single submitter
- CCDC60 p.Ser261Leu Uncertain significance Single submitter
- CCDC60 p.Ser547Ile Uncertain significance Single submitter
- CCDC60 p.Thr111Ile Uncertain significance Single submitter
- CCDC60 p.Thr172Ala Uncertain significance Single submitter
- CCDC60 p.Thr224Lys Uncertain significance Single submitter
- CCDC60 p.Thr228Ile Uncertain significance Single submitter
- CCDC60 p.Thr238Ala Uncertain significance Single submitter
- CCDC60 p.Thr269Ala Uncertain significance Single submitter
- CCDC60 p.Thr2Asn Uncertain significance Single submitter
- CCDC60 p.Thr2Ile Uncertain significance Single submitter
- CCDC60 p.Thr353Arg Uncertain significance Single submitter
- CCDC60 p.Thr370Ala Uncertain significance Single submitter
- CCDC60 p.Trp208Gly Uncertain significance Single submitter
- CCDC60 p.Tyr116His Uncertain significance Single submitter
- CCDC60 p.Val19Asp Uncertain significance Single submitter
- CCDC60 p.Val494Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CCDC60 p.Ser245Ile Uncertain significance Multiple submitters
- CCDC60 p.Ala159Thr Uncertain significance Single submitter
- CCDC60 p.Arg130Cys Uncertain significance Single submitter
- CCDC60 p.Arg155Cys Uncertain significance Single submitter
- CCDC60 p.Arg230His Uncertain significance Single submitter
- CCDC60 p.Arg234Gln Uncertain significance Single submitter
- CCDC60 p.Arg308Trp Uncertain significance Single submitter
- CCDC60 p.Arg411His Uncertain significance Single submitter
- CCDC60 p.Arg421Gly Uncertain significance Single submitter
- CCDC60 p.Arg470Cys Uncertain significance Single submitter
- CCDC60 p.Arg55Gln Uncertain significance Single submitter
- CCDC60 p.Arg57His Uncertain significance Single submitter
- CCDC60 p.Gln84Pro Uncertain significance Single submitter
- CCDC60 p.Glu45Gln Uncertain significance Single submitter
- CCDC60 p.Glu75Gln Uncertain significance Single submitter
- CCDC60 p.Glu91Gly Uncertain significance Single submitter
- CCDC60 p.Leu49Phe Uncertain significance Single submitter
- CCDC60 p.Lys419Asn Uncertain significance Single submitter
- CCDC60 p.Phe133Leu Uncertain significance Single submitter
- CCDC60 p.Phe518Cys Uncertain significance Single submitter
- CCDC60 p.Ser350Cys Uncertain significance Single submitter
- CCDC60 p.Ser351Gly Uncertain significance Single submitter
- CCDC60 p.Ser352Asn Uncertain significance Single submitter
- CCDC60 p.Ser357Gly Uncertain significance Single submitter
- CCDC60 p.Ser460Phe Uncertain significance Single submitter
- CCDC60 p.Val519Met Uncertain significance Single submitter
All CCDC60 variants
Likely benign 5
- p.Arg421His Single submitter
- p.Leu112fs Single submitter
- p.Lys329Arg Single submitter
- p.Lys40Arg Single submitter
- p.Val150= Single submitter
Uncertain significance 104
- p.Ser245Ile Multiple submitters ⚠
- p.Ala159Asp Single submitter ⚠
- p.Ala159Thr Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Ala451Glu Single submitter ⚠
- p.Ala472Thr Single submitter ⚠
- p.Ala548Thr Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg20Leu Single submitter ⚠
- p.Arg226Gly Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg308Trp Single submitter ⚠
- p.Arg369Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg411His Single submitter ⚠
- p.Arg421Gly Single submitter ⚠
- p.Arg470Cys Single submitter ⚠
- p.Arg470His Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Asp465Asn Single submitter ⚠
- p.Gln395Arg Single submitter ⚠
- p.Gln84Pro Single submitter ⚠
- p.Glu119Asp Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.Glu448Lys Single submitter ⚠
- p.Glu45Gln Single submitter ⚠
- p.Glu517Gln Single submitter ⚠
- p.Glu75Gln Single submitter ⚠
- p.Glu91Gly Single submitter ⚠
- p.Gly236Val Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly247Glu Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.Gly544Ala Single submitter ⚠
- p.His171Tyr Single submitter ⚠
- p.His173Gln Single submitter ⚠
- p.His453Arg Single submitter ⚠
- p.Ile106Thr Single submitter ⚠
- p.Ile136Met Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile313Val Single submitter ⚠
- p.Ile433Val Single submitter ⚠
- p.Ile532Val Single submitter ⚠
- p.Ile543Thr Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu145Val Single submitter ⚠
- p.Leu163His Single submitter ⚠
- p.Leu466Ile Single submitter ⚠
- p.Leu476Pro Single submitter ⚠
- p.Leu486Met Single submitter ⚠
- p.Leu486Val Single submitter ⚠
- p.Leu49Phe Single submitter ⚠
- p.Lys332Glu Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys419Asn Single submitter ⚠
- p.Lys50Glu Single submitter ⚠
- p.Lys96Thr Single submitter ⚠
- p.Met225Ile Single submitter ⚠
- p.Met36Ile Single submitter ⚠
- p.Met386Thr Single submitter ⚠
- p.Met405Ile Single submitter ⚠
- p.Met405Thr Single submitter ⚠
- p.Phe133Leu Single submitter ⚠
- p.Phe518Cys Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro223Ser Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Ser261Leu Single submitter ⚠
- p.Ser350Cys Single submitter ⚠
- p.Ser351Gly Single submitter ⚠
- p.Ser352Asn Single submitter ⚠
- p.Ser357Gly Single submitter ⚠
- p.Ser460Phe Single submitter ⚠
- p.Ser547Ile Single submitter ⚠
- p.Thr111Ile Single submitter ⚠
- p.Thr172Ala Single submitter ⚠
- p.Thr224Lys Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr238Ala Single submitter ⚠
- p.Thr269Ala Single submitter ⚠
- p.Thr2Asn Single submitter ⚠
- p.Thr2Ile Single submitter ⚠
- p.Thr353Arg Single submitter ⚠
- p.Thr370Ala Single submitter ⚠
- p.Trp208Gly Single submitter ⚠
- p.Tyr116His Single submitter ⚠
- p.Val19Asp Single submitter ⚠
- p.Val494Ile Single submitter ⚠
- p.Val519Met Single submitter ⚠