CCDC62 — 103 ClinVar variants
All ClinVar germline CCDC62 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 3 Benign · 6 Likely benign · 92 Uncertain significance
Full CCDC62 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC62 p.Ala271Ser Uncertain significance Single submitter
- CCDC62 p.Ala322Asp Uncertain significance Single submitter
- CCDC62 p.Ala503Gly Uncertain significance Single submitter
- CCDC62 p.Ala6Ser Uncertain significance Single submitter
- CCDC62 p.Arg11Cys Uncertain significance Single submitter
- CCDC62 p.Arg192His Uncertain significance Single submitter
- CCDC62 p.Arg237Gln Uncertain significance Single submitter
- CCDC62 p.Arg277His Uncertain significance Single submitter
- CCDC62 p.Arg27Gln Uncertain significance Single submitter
- CCDC62 p.Arg40Gln Uncertain significance Single submitter
- CCDC62 p.Arg548Cys Uncertain significance Single submitter
- CCDC62 p.Arg62Trp Uncertain significance Single submitter
- CCDC62 p.Arg642Cys Uncertain significance Single submitter
- CCDC62 p.Arg71His Uncertain significance Single submitter
- CCDC62 p.Arg82Lys Uncertain significance Single submitter
- CCDC62 p.Asn227Ser Uncertain significance Single submitter
- CCDC62 p.Asn2Tyr Uncertain significance Single submitter
- CCDC62 p.Asn45Ser Uncertain significance Single submitter
- CCDC62 p.Asp225Asn Uncertain significance Single submitter
- CCDC62 p.Asp342Asn Uncertain significance Single submitter
- CCDC62 p.Asp355Asn Uncertain significance Single submitter
- CCDC62 p.Asp488Asn Uncertain significance Single submitter
- CCDC62 p.Cys376Arg Uncertain significance Single submitter
- CCDC62 p.Cys428Tyr Uncertain significance Single submitter
- CCDC62 p.Cys437Tyr Uncertain significance Single submitter
- CCDC62 p.Cys516Arg Uncertain significance Single submitter
- CCDC62 p.Gln100Lys Uncertain significance Single submitter
- CCDC62 p.Gln12Leu Uncertain significance Single submitter
- CCDC62 p.Gln148Arg Uncertain significance Single submitter
- CCDC62 p.Gln677Leu Uncertain significance Single submitter
-
CCDC62 p.Glu129Gln
Uncertain significance
Single submitter
spermatogenic failure 67
- CCDC62 p.Glu136Asp Uncertain significance Single submitter
- CCDC62 p.Glu445Ala Uncertain significance Single submitter
- CCDC62 p.Gly10Arg Uncertain significance Single submitter
- CCDC62 p.Gly439Val Uncertain significance Single submitter
- CCDC62 p.Gly552Arg Uncertain significance Single submitter
- CCDC62 p.His564Gln Uncertain significance Single submitter
- CCDC62 p.His658Asp Uncertain significance Single submitter
- CCDC62 p.Ile34Thr Uncertain significance Single submitter
- CCDC62 p.Ile398Val Uncertain significance Single submitter
- CCDC62 p.Ile559Thr Uncertain significance Single submitter
- CCDC62 p.Ile574Leu Uncertain significance Single submitter
- CCDC62 p.Ile574Val Uncertain significance Single submitter
- CCDC62 p.Ile656Phe Uncertain significance Single submitter
- CCDC62 p.Leu362Phe Uncertain significance Single submitter
- CCDC62 p.Leu587Val Uncertain significance Single submitter
- CCDC62 p.Leu8Phe Uncertain significance Single submitter
- CCDC62 p.Lys357Arg Uncertain significance Single submitter
- CCDC62 p.Lys429Glu Uncertain significance Single submitter
- CCDC62 p.Lys668Arg Uncertain significance Single submitter
- CCDC62 p.Met317Val Uncertain significance Single submitter
- CCDC62 p.Met329Val Uncertain significance Single submitter
- CCDC62 p.Met510Val Uncertain significance Single submitter
- CCDC62 p.Pro410Leu Uncertain significance Single submitter
- CCDC62 p.Pro449Arg Uncertain significance Single submitter
- CCDC62 p.Pro453Leu Uncertain significance Single submitter
- CCDC62 p.Pro4Leu Uncertain significance Single submitter
- CCDC62 p.Pro4Thr Uncertain significance Single submitter
- CCDC62 p.Pro672Leu Uncertain significance Single submitter
- CCDC62 p.Ser493Thr Uncertain significance Single submitter
- CCDC62 p.Ser496Leu Uncertain significance Single submitter
- CCDC62 p.Ser619Leu Uncertain significance Single submitter
- CCDC62 p.Ser88Leu Uncertain significance Single submitter
- CCDC62 p.Thr137Ile Uncertain significance Single submitter
- CCDC62 p.Thr199Ser Uncertain significance Single submitter
- CCDC62 p.Thr440Ser Uncertain significance Single submitter
- CCDC62 p.Thr471Asn Uncertain significance Single submitter
- CCDC62 p.Thr592Met Uncertain significance Single submitter
- CCDC62 p.Thr662Ile Uncertain significance Single submitter
- CCDC62 p.Thr67Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CCDC62 p.Ala190Gly Uncertain significance Single submitter
- CCDC62 p.Ala271Glu Uncertain significance Single submitter
- CCDC62 p.Arg636Cys Uncertain significance Single submitter
- CCDC62 p.Arg71Cys Uncertain significance Single submitter
- CCDC62 p.Asn302Lys Uncertain significance Single submitter
- CCDC62 p.Glu266Gly Uncertain significance Single submitter
- CCDC62 p.Glu76Gly Uncertain significance Single submitter
- CCDC62 p.His176Arg Uncertain significance Single submitter
- CCDC62 p.Ile288Thr Uncertain significance Single submitter
- CCDC62 p.Ile86Met Uncertain significance Single submitter
- CCDC62 p.Leu165Ile Uncertain significance Single submitter
- CCDC62 p.Leu187Val Uncertain significance Single submitter
- CCDC62 p.Leu66Phe Uncertain significance Single submitter
- CCDC62 p.Lys205Thr Uncertain significance Single submitter
- CCDC62 p.Lys272Asn Uncertain significance Single submitter
- CCDC62 p.Met47Val Uncertain significance Single submitter
- CCDC62 p.Met644Leu Uncertain significance Single submitter
- CCDC62 p.Ser181Leu Uncertain significance Single submitter
- CCDC62 p.Thr122Met Uncertain significance Single submitter
- CCDC62 p.Thr160Arg Uncertain significance Single submitter
- CCDC62 p.Thr394Met Uncertain significance Single submitter
- CCDC62 p.Trp58Arg Uncertain significance Single submitter
All CCDC62 variants
Pathogenic 1
- p.Gln148Ter No assertion criteria spermatogenic failure 67
Likely pathogenic 1
- p.Asn45fs Single submitter spermatogenic failure 67
Benign 3
- p.Gln364= Multiple submitters
- p.Ile14= Single submitter
- p.Tyr313Phe Single submitter
Likely benign 6
- p.Ala6Thr Single submitter
- p.Asn615Ser Single submitter
- p.Pro518= Single submitter
- p.Thr394Ala Single submitter
- p.Val219Ile Single submitter
- p.Val258Ala Single submitter
Uncertain significance 92
- p.Ala190Gly Single submitter ⚠
- p.Ala271Glu Single submitter ⚠
- p.Ala271Ser Single submitter ⚠
- p.Ala322Asp Single submitter ⚠
- p.Ala503Gly Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Arg11Cys Single submitter ⚠
- p.Arg192His Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg277His Single submitter ⚠
- p.Arg27Gln Single submitter ⚠
- p.Arg40Gln Single submitter ⚠
- p.Arg548Cys Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg636Cys Single submitter ⚠
- p.Arg642Cys Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Arg82Lys Single submitter ⚠
- p.Asn227Ser Single submitter ⚠
- p.Asn2Tyr Single submitter ⚠
- p.Asn302Lys Single submitter ⚠
- p.Asn45Ser Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp342Asn Single submitter ⚠
- p.Asp355Asn Single submitter ⚠
- p.Asp488Asn Single submitter ⚠
- p.Cys376Arg Single submitter ⚠
- p.Cys428Tyr Single submitter ⚠
- p.Cys437Tyr Single submitter ⚠
- p.Cys516Arg Single submitter ⚠
- p.Gln100Lys Single submitter ⚠
- p.Gln12Leu Single submitter ⚠
- p.Gln148Arg Single submitter ⚠
- p.Gln677Leu Single submitter ⚠
- p.Glu129Gln Single submitter spermatogenic failure 67 ⚠
- p.Glu136Asp Single submitter ⚠
- p.Glu266Gly Single submitter ⚠
- p.Glu445Ala Single submitter ⚠
- p.Glu76Gly Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly439Val Single submitter ⚠
- p.Gly552Arg Single submitter ⚠
- p.His176Arg Single submitter ⚠
- p.His564Gln Single submitter ⚠
- p.His658Asp Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile34Thr Single submitter ⚠
- p.Ile398Val Single submitter ⚠
- p.Ile559Thr Single submitter ⚠
- p.Ile574Leu Single submitter ⚠
- p.Ile574Val Single submitter ⚠
- p.Ile656Phe Single submitter ⚠
- p.Ile86Met Single submitter ⚠
- p.Leu165Ile Single submitter ⚠
- p.Leu187Val Single submitter ⚠
- p.Leu362Phe Single submitter ⚠
- p.Leu587Val Single submitter ⚠
- p.Leu66Phe Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys205Thr Single submitter ⚠
- p.Lys272Asn Single submitter ⚠
- p.Lys357Arg Single submitter ⚠
- p.Lys429Glu Single submitter ⚠
- p.Lys668Arg Single submitter ⚠
- p.Met317Val Single submitter ⚠
- p.Met329Val Single submitter ⚠
- p.Met47Val Single submitter ⚠
- p.Met510Val Single submitter ⚠
- p.Met644Leu Single submitter ⚠
- p.Pro410Leu Single submitter ⚠
- p.Pro449Arg Single submitter ⚠
- p.Pro453Leu Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro672Leu Single submitter ⚠
- p.Ser181Leu Single submitter ⚠
- p.Ser493Thr Single submitter ⚠
- p.Ser496Leu Single submitter ⚠
- p.Ser619Leu Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Thr122Met Single submitter ⚠
- p.Thr137Ile Single submitter ⚠
- p.Thr160Arg Single submitter ⚠
- p.Thr199Ser Single submitter ⚠
- p.Thr394Met Single submitter ⚠
- p.Thr440Ser Single submitter ⚠
- p.Thr471Asn Single submitter ⚠
- p.Thr592Met Single submitter ⚠
- p.Thr662Ile Single submitter ⚠
- p.Thr67Ala Single submitter ⚠
- p.Trp58Arg Single submitter ⚠