CCDC63 — 84 ClinVar variants
All ClinVar germline CCDC63 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
7 Likely benign · 77 Uncertain significance
Full CCDC63 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC63 p.Ala108Thr Uncertain significance Single submitter
- CCDC63 p.Ala144Val Uncertain significance Single submitter
- CCDC63 p.Ala280Val Uncertain significance Single submitter
- CCDC63 p.Arg230Gln Uncertain significance Single submitter
- CCDC63 p.Arg250Gln Uncertain significance Single submitter
- CCDC63 p.Arg32Gln Uncertain significance Single submitter
- CCDC63 p.Arg336Trp Uncertain significance Single submitter
- CCDC63 p.Arg51Gln Uncertain significance Single submitter
- CCDC63 p.Arg539Gln Uncertain significance Single submitter
- CCDC63 p.Arg97Gln Uncertain significance Single submitter
- CCDC63 p.Asp359Glu Uncertain significance Single submitter
- CCDC63 p.Gln37Arg Uncertain significance Single submitter
- CCDC63 p.Gln431Pro Uncertain significance Single submitter
- CCDC63 p.Glu119Gln Uncertain significance Single submitter
- CCDC63 p.Glu298Gly Uncertain significance Single submitter
- CCDC63 p.Glu451Ala Uncertain significance Single submitter
- CCDC63 p.Glu473Gly Uncertain significance Single submitter
- CCDC63 p.Gly401Ala Uncertain significance Single submitter
- CCDC63 p.Gly471Arg Uncertain significance Single submitter
- CCDC63 p.Gly471Glu Uncertain significance Single submitter
- CCDC63 p.Gly545Glu Uncertain significance Single submitter
- CCDC63 p.His155Arg Uncertain significance Single submitter
- CCDC63 p.Ile450Ser Uncertain significance Single submitter
- CCDC63 p.Ile500Leu Uncertain significance Single submitter
- CCDC63 p.Leu120Met Uncertain significance Single submitter
- CCDC63 p.Leu363Val Uncertain significance Single submitter
- CCDC63 p.Lys129Thr Uncertain significance Single submitter
- CCDC63 p.Lys23Arg Uncertain significance Single submitter
- CCDC63 p.Lys55Asn Uncertain significance Single submitter
- CCDC63 p.Met141Thr Uncertain significance Single submitter
- CCDC63 p.Met234Ile Uncertain significance Single submitter
- CCDC63 p.Met347Ile Uncertain significance Single submitter
- CCDC63 p.Met80Thr Uncertain significance Single submitter
- CCDC63 p.Phe418Leu Uncertain significance Single submitter
- CCDC63 p.Pro15Ser Uncertain significance Single submitter
- CCDC63 p.Pro483Thr Uncertain significance Single submitter
- CCDC63 p.Pro508His Uncertain significance Single submitter
- CCDC63 p.Ser547Asn Uncertain significance Single submitter
- CCDC63 p.Thr159Asn Uncertain significance Single submitter
- CCDC63 p.Thr65Ala Uncertain significance Single submitter
- CCDC63 p.Val42Ala Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- CCDC63 p.Ala27Val Uncertain significance Single submitter
- CCDC63 p.Arg148Trp Uncertain significance Single submitter
- CCDC63 p.Arg237Cys Uncertain significance Single submitter
- CCDC63 p.Arg237His Uncertain significance Single submitter
- CCDC63 p.Arg254Cys Uncertain significance Single submitter
- CCDC63 p.Arg465Cys Uncertain significance Single submitter
- CCDC63 p.Asp13Tyr Uncertain significance Single submitter
- CCDC63 p.Glu30Asp Uncertain significance Single submitter
- CCDC63 p.Glu348Gln Uncertain significance Single submitter
- CCDC63 p.Glu62Ala Uncertain significance Single submitter
- CCDC63 p.Glu72Gly Uncertain significance Single submitter
- CCDC63 p.Glu95Ala Uncertain significance Single submitter
- CCDC63 p.Gly317Arg Uncertain significance Single submitter
- CCDC63 p.Gly486Cys Uncertain significance Single submitter
- CCDC63 p.His258Arg Uncertain significance Single submitter
- CCDC63 p.Ile182Thr Uncertain significance Single submitter
- CCDC63 p.Ile450Thr Uncertain significance Single submitter
- CCDC63 p.Leu163Pro Uncertain significance Single submitter
- CCDC63 p.Leu310Met Uncertain significance Single submitter
- CCDC63 p.Leu386Gln Uncertain significance Single submitter
- CCDC63 p.Lys103Glu Uncertain significance Single submitter
- CCDC63 p.Lys207Glu Uncertain significance Single submitter
- CCDC63 p.Lys312Thr Uncertain significance Single submitter
- CCDC63 p.Met210Lys Uncertain significance Single submitter
- CCDC63 p.Met234Arg Uncertain significance Single submitter
- CCDC63 p.Pro493His Uncertain significance Single submitter
- CCDC63 p.Pro501Ser Uncertain significance Single submitter
- CCDC63 p.Ser377Pro Uncertain significance Single submitter
- CCDC63 p.Ser83Leu Uncertain significance Single submitter
- CCDC63 p.Thr338Met Uncertain significance Single submitter
- CCDC63 p.Thr341Arg Uncertain significance Single submitter
- CCDC63 p.Thr341Met Uncertain significance Single submitter
- CCDC63 p.Thr390Met Uncertain significance Single submitter
- CCDC63 p.Thr435Ala Uncertain significance Single submitter
- CCDC63 p.Thr435Met Uncertain significance Single submitter
- CCDC63 p.Thr439Ile Uncertain significance Single submitter
All CCDC63 variants
Likely benign 7
- p.Arg353Lys Single submitter
- p.Arg387Lys Single submitter
- p.Asp359Asn Single submitter
- p.Gly401Arg Single submitter
- p.Lys49Asn Single submitter
- p.Phe187Tyr Single submitter
- p.Ser89Asn Single submitter
Uncertain significance 77
- p.Ala108Thr Single submitter ⚠
- p.Ala144Val Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala280Val Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg230Gln Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg237His Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg336Trp Single submitter ⚠
- p.Arg465Cys Single submitter ⚠
- p.Arg51Gln Single submitter ⚠
- p.Arg539Gln Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Asp13Tyr Single submitter ⚠
- p.Asp359Glu Single submitter ⚠
- p.Gln37Arg Single submitter ⚠
- p.Gln431Pro Single submitter ⚠
- p.Glu119Gln Single submitter ⚠
- p.Glu298Gly Single submitter ⚠
- p.Glu30Asp Single submitter ⚠
- p.Glu348Gln Single submitter ⚠
- p.Glu451Ala Single submitter ⚠
- p.Glu473Gly Single submitter ⚠
- p.Glu62Ala Single submitter ⚠
- p.Glu72Gly Single submitter ⚠
- p.Glu95Ala Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly401Ala Single submitter ⚠
- p.Gly471Arg Single submitter ⚠
- p.Gly471Glu Single submitter ⚠
- p.Gly486Cys Single submitter ⚠
- p.Gly545Glu Single submitter ⚠
- p.His155Arg Single submitter ⚠
- p.His258Arg Single submitter ⚠
- p.Ile182Thr Single submitter ⚠
- p.Ile450Ser Single submitter ⚠
- p.Ile450Thr Single submitter ⚠
- p.Ile500Leu Single submitter ⚠
- p.Leu120Met Single submitter ⚠
- p.Leu163Pro Single submitter ⚠
- p.Leu310Met Single submitter ⚠
- p.Leu363Val Single submitter ⚠
- p.Leu386Gln Single submitter ⚠
- p.Lys103Glu Single submitter ⚠
- p.Lys129Thr Single submitter ⚠
- p.Lys207Glu Single submitter ⚠
- p.Lys23Arg Single submitter ⚠
- p.Lys312Thr Single submitter ⚠
- p.Lys55Asn Single submitter ⚠
- p.Met141Thr Single submitter ⚠
- p.Met210Lys Single submitter ⚠
- p.Met234Arg Single submitter ⚠
- p.Met234Ile Single submitter ⚠
- p.Met347Ile Single submitter ⚠
- p.Met80Thr Single submitter ⚠
- p.Phe418Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro483Thr Single submitter ⚠
- p.Pro493His Single submitter ⚠
- p.Pro501Ser Single submitter ⚠
- p.Pro508His Single submitter ⚠
- p.Ser377Pro Single submitter ⚠
- p.Ser547Asn Single submitter ⚠
- p.Ser83Leu Single submitter ⚠
- p.Thr159Asn Single submitter ⚠
- p.Thr338Met Single submitter ⚠
- p.Thr341Arg Single submitter ⚠
- p.Thr341Met Single submitter ⚠
- p.Thr390Met Single submitter ⚠
- p.Thr435Ala Single submitter ⚠
- p.Thr435Met Single submitter ⚠
- p.Thr439Ile Single submitter ⚠
- p.Thr65Ala Single submitter ⚠
- p.Val42Ala Single submitter ⚠